To assess changes in infant vaccination coverage in Flanders since 1999, an EPI-survey was performed in 2005. The parents of 1354 children aged 18-24 months were interviewed at home and the vaccination documents were checked. Several factors possibly related to vaccination status were examined with parametric and non-parametric methods. The coverage rate of recommended vaccines, i.e. poliomyelitis, tetanus-diphtheria-pertussis, H influenzae type b (Hib), hepatitis B, measles-mumps-rubella (MMR) and meningococcal C, reached at least 92.2%, which is a significant rise for MMR, hepatitis B and Hib since 1999.The vaccinating physician, the employment situation of the mother and the family income were significant risk factors for incomplete or invalid vaccination.