Differences in single gene expression patterns and signaling pathways between Black and White patients in high grade endometrioid endometrial cancer independent of BMI

circRNAs in Endometrial Cancer—A Promising Biomarker: State of the Art

“…Wilhite et al [ 36 ] showed that black patients with endometroid EC show less frequent mutations in the ARID1A, PTEN, or PIK3CA genes, making the black race have a potentially high risk of EC [ 36 ]. In turn, Pearce et al [ 37 ], conducting a pilot study, concluded that in black women with endometrioid EC grades 2 and 3, they had individual differences at the level of pathways (e.g., activated opioid signaling, inhibited corticotropin-releasing hormone signaling) and genes compared with white women. The researchers also noted that regardless of BMI, there were many differences between races [ 37 ].…”

“…In turn, Pearce et al [ 37 ], conducting a pilot study, concluded that in black women with endometrioid EC grades 2 and 3, they had individual differences at the level of pathways (e.g., activated opioid signaling, inhibited corticotropin-releasing hormone signaling) and genes compared with white women. The researchers also noted that regardless of BMI, there were many differences between races [ 37 ]. However, further research in this direction is necessary.…”