Differences in Susceptibility of Mice among Various Strains to Oral Infection with &lt;I&gt;Corynebacterium kutscheri&lt;/I&gt;

Amao, Hiromi; Komukai, Yumi; Sugiyama, Masahiro; Saito, Tsuneo; Takahashi, Kazuaki W.; Saito, Manabu

doi:10.1538/expanim1978.42.4_539

Cited by 8 publications

(3 citation statements)

References 18 publications

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“…Strain differences in colonization sites (9) and susceptibility have been reported. C57BL/6 and B10.BR/SgSn mice are among the more resistant strains, while Swiss, BALB/cCr, and A/J are among the more susceptible strains (10,295). Strain susceptibility may reflect differences in the efficiency of mononuclear phagocytes (296) or cytokine responses (352).…”

Section: Multiple and Miscellaneous Systemsmentioning

confidence: 99%

Natural Pathogens of Laboratory Mice, Rats, and Rabbits and Their Effects on Research

1998

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SUMMARY Laboratory mice, rats, and rabbits may harbor a variety of viral, bacterial, parasitic, and fungal agents. Frequently, these organisms cause no overt signs of disease. However, many of the natural pathogens of these laboratory animals may alter host physiology, rendering the host unsuitable for many experimental uses. While the number and prevalence of these pathogens have declined considerably, many still turn up in laboratory animals and represent unwanted variables in research. Investigators using mice, rats, and rabbits in biomedical experimentation should be aware of the profound effects that many of these agents can have on research.

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Section: Multiple and Miscellaneous Systemsmentioning

confidence: 99%

Natural Pathogens of Laboratory Mice, Rats, and Rabbits and Their Effects on Research

1998

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“…We have also found differences in susceptibility to infection with C. kutscheri among sexes and various mouse strains (Amao et al 1993, Komukai et al 1999. These differences may be important when screening for infection with C. kutscheri.…”

Section: Discussionmentioning

confidence: 51%

Detection of Corynebacterium kutscheri in the faeces of subclinically infected mice

Amao¹,

Moriguchi²,

Komukai³

et al. 2008

Lab Anim

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SummaryMice were infected experimentally and subclinically with Corynebacterium kutscheri to recover the organism from mice faeces. The faeces were then cultured using selective furazolidone-nalidixic acid-colimycin agar. The number of C. kutscheri per gram of fresh faeces varied from mouse to mouse, but once established in the intestine, the organism was excreted in the faeces for at least five months. Viable bacteria were detected in most of the faecal samples, including those stored in the animal room for five days. The number of organisms in the stored faeces decreased gradually but did not differ significantly from those in the fresh faeces until they had been stored for more than three days. Many infected mice excreted between 10 4.77 and 10 5.37 colony forming units (CFU) of C. kutscheri per day in their faeces, and one mouse even excreted 10 3.74 CFU at eight weeks postinfection. These values showed little daily variation. Our present study showed that subclinically infected mice discharged the organism continuously and persistently in their faeces. Therefore, faecal samples would be useful for monitoring infection with C. kutscheri in living mice in a manner that is not stressful for the animals.

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“…Sin embargo, son necesarios 60 días post-tratamiento para la normalización de los valores del hematócrito (VASIL'EVA, 1974) y de la enteroquinasa, fosfatasa alcalina y de la microflora de la bilis, intestino delgado y colon (ABALIKHIN, 1982a(ABALIKHIN, , 1982b. (TARRY, 1969;SALIMOV, 1972d;CHANDRA, 1973). Sin embargo, las diferencias en el período de prepatencia pueden ser debidas a las condiciones climáticas, resistencia individual del hospedador y diferencias genéticas derivadas de la distinta distribución geográfica del parásito (CHANDRA, 1973).…”

Section: Marcadoras Hepáticas En La Dicroceliosisunclassified

Estudios experimentales sobre la dicroceliosis

Campo Santana

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Cuadro 20.-Días p.i. entre los que se detectaron diferencias estadísticamente significativas (test LSD) en los valores de albúmina, obtenidos de los corderos infectados con 1.000 metacercarias. DÍASP. I. 120 150 180 0 ** * ** 60 ** 90 ** * p ≤ 0,01; ** p ≤ 0,05 Cuadro 21.-Días p.i. entre los que se detectaron diferencias estadísticamente significativas (test LSD) en los valores de LDH, obtenidos de los corderos infectados con 1.000 metacercarias. DIAS P.I. 60 90 120 150 0 * ** ** ** 30 ** ** ** * p ≤ 0,01; ** p ≤ 0,05 Cuadro 25.-Días p.i. entre los que se detectaron diferencias estadísticamente significativas (test LSD) en los valores de albúmina, obtenidos de los corderos infectados con 3.000 metacercarias. DIAS P.I. 30 60 90 120 150 180 0 * ** * ** ** 30 ** 60 ** *p ≤ 0,01; **p ≤ 0,05 Cuadro 26.-Días p.i. entre los que se detectaron diferencias estadísticamente significativas (test LSD) en los valores de bilirrubina, obtenidos de los corderos infectados con 3.000 metacercarias. DIAS P.I. 120 150 0 ** 30 * 60 * 90 * 120 * *p ≤ 0,01; **p ≤ 0,05 Cuadro 27.-Días p.i. entre los que se detectaron diferencias estadísticamente significativas (test LSD) en los valores de glucosa, obtenidos de los corderos infectados con 3.000 metacercarias. DIAS P.I. 30 60 90 150 180 0 * ** * 30 ** * 60 * 90 ** * 120 ** *p ≤ 0,01; **p ≤ 0,05 Cuadro 28.-Días p.i. entre los que se detectaron diferencias estadísticamente significativas (test LSD) en los valores de FA, obtenidos de los corderos infectados con 3.000 metacercarias. Al realizar los correspondientes análisis de varianza de una vía, sólo se observaron diferencias estadísticamente significativas en los valores de neutrófilos (F = 5,81; p ≤ 0,001; g.l. = 10 y 17) de los animales infectados, cuando se consideraron los distintos días p.i. Los resultados del test LSD se resumen en el Cuadro 38. DIAS P.I. 30 60 150 165 180 0 ** ** * 15 ** * 30 * ** 45 ** * 60 * ** * 90 ** * 120 ** * 165 ** *p ≤ 0,01; **p ≤ 0,05 Cuadro 38.-Días p.i. entre los que se detectaron diferencias estadísticamente significativas (test LSD) en los valores de neutrófilos obtenidos de los corderos infectados con 1.000 metacercarias. DIAS P.I. 15 45 60 75 90 120 135 150 0 ** 15 * ** * * ** ** ** 30 ** ** ** 45 ** 60 75 * 90 ** *p ≤ 0,01; **p ≤ 0,05 Cuadro 44.-Días p.i. entre los que se detectaron diferencias estadísticamente significativas (test LSD) en los valores de eritrocitos obtenidos de los corderos infectados con 3.000 metacercarias. DIAS P.I. 45 90 105 135 150 165 0 ** * 15 * ** 30 * 45 ** * * 60 ** ** 75 ** ** ** 90 * ** * * * 120 ** ** *p ≤ 0,01; **p ≤ 0,05 Cuadro 45.-Días p.i. entre los que se detectaron diferencias estadísticamente significativas (test LSD) en los valores de leucocitos obtenidos de los corderos infectados con 3.000 metacercarias.

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Differences in Susceptibility of Mice among Various Strains to Oral Infection with <I>Corynebacterium kutscheri</I>

Cited by 8 publications

References 18 publications

Natural Pathogens of Laboratory Mice, Rats, and Rabbits and Their Effects on Research

Natural Pathogens of Laboratory Mice, Rats, and Rabbits and Their Effects on Research

Detection of Corynebacterium kutscheri in the faeces of subclinically infected mice

Estudios experimentales sobre la dicroceliosis

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