Differences in the Association Between Apolipoprotein E Genotype and Mortality Across Populations

Ewbank, Douglas C.

doi:10.1093/gerona/62.8.899

Cited by 40 publications

(43 citation statements)

References 68 publications

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“…However, two loci that are repeatedly found by GWAS of aging are APOE (Deelen et al, 2011; Ewbank, 2007; Gerdes, Jeune, Ranberg, Nybo, & Vaupel, 2000) and FOXO3A (Anselmi et al, 2009; Flachsbart et al, 2009; Li et al, 2009; Pawlikowska et al, 2009; Willcox et al, 2008). Similar to AD, APOE ε2 is found to be enriched in elderly and centenarians compared to younger individuals (Seripa et al, 2006).…”

Section: Molecular Links Between Aging and Admentioning

confidence: 99%

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

et al. 2018

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Alzheimer's disease is the most prevalent cause of dementia, which is defined by the combined presence of amyloid and tau, but researchers are gradually moving away from the simple assumption of linear causality proposed by the original amyloid hypothesis. Aging is the main risk factor for Alzheimer's disease that cannot be explained by amyloid hypothesis. To evaluate how aging and Alzheimer's disease are intrinsically interwoven with each other, we review and summarize evidence from molecular, cellular, and system level. In particular, we focus on study designs, treatments, or interventions in Alzheimer's disease that could also be insightful in aging and vice versa.

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Section: Molecular Links Between Aging and Admentioning

confidence: 99%

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

et al. 2018

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“…A common polymorphism in the ApoE gene, coding for three common isoforms (E2, E3, and E4) has been studied extensively. [1][2][3] Largely reflecting its presence in atherogenic lipoprotein fractions, there has been a significant increased interest in ApoB levels as a predictor of CVD. This has been underscored in several recent large prospective studies.…”

Section: Introductionmentioning

confidence: 99%

Integrated Role of Two Apoliprotein E Polymorphisms on Apolipoprotein B Levels and Coronary Artery Disease in a Biethnic Population

Öztürk

Enkhmaa

Shachter

et al. 2010

Metabolic Syndrome and Related Disorders

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Background: Apolipoprotein E (ApoE) plays a major role in lipoprotein metabolism and genetic variability of ApoE confers susceptibility to coronary artery disease (CAD). Beyond variability in the coding region, promoter polymorphisms in the ApoE gene impact on ApoE transcription. Methods: We determined the ApoE À 491 A/T promoter polymorphism, ApoE isoforms, lipid and lipoprotein levels, and CAD risk factors in 313 Caucasians and 215 African Americans.

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“…Although several studies reported the adverse effect of ε4 allele on survival in older people (Tilvis et al 1998;Hayden et al 2005) and in a wide variety of ethnic groups (Ewbank 2007), and significant associations of the ε4 allele with mortality dependently of AD (Dal Forno et al 2002;Rosvall et al 2009) or cognitive impairment (Rockwood et al 2008) have been shown, other studies reported controversial results on the relationship between this allele and longevity (Gerdes et al 1992), or with the risk of vascular or nonvascular mortality (Panza et al 2007). Indeed, the lack of association between the ε4 allele and increased risk of mortality reported in the present study is consistent with several other reports (Skoog et al 1998;Koivisto et al 2000;Frisoni et al 2001;Slooter et al 2001;Tschanz et al 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, differences in the association between this polymorphism and mortality have been reported across European (Ewbank 2004) and other populations (Ewbank 2007). Aim of the present study was to explore the potential association of APOE alleles on all-cause mortality in a large population of Caucasian hospitalized elderly patients from Central and Southern Italy, taking also into account the functional disability, cognitive impairment, malnutrition, and the occurrence of common age-related diseases.…”

Section: Introductionmentioning

confidence: 98%

Apolipoprotein E-related all-cause mortality in hospitalized elderly patients

Matera

Sancarlo

Gravina

et al. 2010

AGE

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The most common apolipoprotein E (APOE) allelic variation is implicated in many age-related diseases and human longevity with controversial findings. We investigated the effect of APOE gene polymorphism on all-cause mortality in elderly patients taking into consideration the functional disability, cognitive impairment, malnutrition, and the occurrence of common age-related diseases. APOE genotypes were determined in 2,124 geriatric hospitalized patients (46.5% men and 53.5% women; mean age, 78.2 +/- 7.1 years; range, 65-100 years). At hospital admission, all patients underwent a comprehensive geriatric assessment to evaluate functional disability, cognitive status, nutritional status, and comorbidity. The main and secondary diagnoses at hospital discharge were also recorded. Mortality status was evaluated in all patients after a maximum follow-up of 5 years (range, from 1.26 to 5.23 years; median, 2.86 years). During the study period, 671 patients died (32.0%). At hospital admission, these patients showed a significant higher prevalence of cardiovascular diseases (56.3% vs 53.4%; p = 0.007), neoplasias (32.3% vs 13.7%; p < 0.001), and lower prevalence of neurodegenerative diseases (17.7% vs 20.7%; p < 0.001) than survived patients. Moreover, they also showed an higher prevalence of disability (52.0% vs 25.6%; p < 0.001), cognitive impairment (31.0% vs 18.8%; p < 0.001), and malnutrition (74.0% vs 46.1%; p < 0.001) than survived patients. In the overall study population, the APOE epsilon2 allele was significantly associated to neurodegenerative diseases (odds ratio = 0.59; 95% confidence interval (CI), 0.37-0.94). No significant association between the APOE polymorphism and disability, malnutrition, co-morbidity status, and with all-cause mortality was observed. In patients with cardiovascular diseases, however, a decreased risk of all-cause mortality was found in the epsilon2 allele carriers (hazard ratio = 0.56; 95% CI, 0.36-0.88). In this population, APOE allele variants might play a role on cardiovascular disease-related mortality.

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Differences in the Association Between Apolipoprotein E Genotype and Mortality Across Populations

Cited by 40 publications

References 68 publications

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

Integrated Role of Two Apoliprotein E Polymorphisms on Apolipoprotein B Levels and Coronary Artery Disease in a Biethnic Population

Apolipoprotein E-related all-cause mortality in hospitalized elderly patients

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