Differences in the Dynamics of Sweat Secretion in Atopic Children*

Rovenský, Jozef; Saxl, O

doi:10.1038/jid.1964.138

Cited by 25 publications

(7 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although it is well known that sweating may cause itching and secondary eczema, the results of previous studies on sweat gland function in AD are controversial. Sweat secretion in AD has been reported to be decreased, 3,14 increased 15,16 or normal 17 in various experimental studies. Most previous investigations assessed sweating function using a direct stimulation sweating test in which intradermal acetylcholine injection resulted in direct sweat responses 16–18 .…”

Section: Discussionmentioning

confidence: 99%

Impaired sweating function in adult atopic dermatitis: results of the quantitative sudomotor axon reflex test

Eishi

et al. 2002

Br J Dermatol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Impaired sweating function in adult atopic dermatitis: results of the quantitative sudomotor axon reflex test

Eishi

et al. 2002

Br J Dermatol

View full text Add to dashboard Cite

show abstract

“…Indeed, much less attention has been focused on the fact that reduced sweating in AD patients is one of the most important factors, although not enough in itself, that causes the skin dryness: it may contribute more profoundly to skin dryness in AD than the reduction in ceramide and FLG , given the great capacity of sweat to increase skin surface hydration. Reflecting such neglect in previous studies on the role of sweat in AD, previous attempts to evaluate sweating disturbance in AD have yielded conflicting results . One explanation for these conflicting results is that there was no useful quantitative method that allows an accurate assessment of individual sweat glands/ducts actively delivering sweat over a time frame.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, there have been few studies investigating the role of sweating on the development of AD and such research has been hampered both by the paucity of reproducible and quantitative methods to accurately evaluate the activity of each sweat gland/duct in a well‐defined location and by the lack of sweat glands/ducts in animal skin, in which a variety of analyses have been performed. In addition, conflicting data regarding whether sweating responses are impaired, normal or enhanced in patients with AD would divert the research interest away from investigating the role for sweating responses in the pathogenesis. A consensus has emerged from these studies that sweating responses are impaired and retarded in AD patients .…”

Section: Introductionmentioning

confidence: 99%

A novel method to assess the potential role of sweating abnormalities in the pathogenesis of atopic dermatitis

Shimoda‐Komatsu

Sato

Yamazaki

et al. 2017

Experimental Dermatology

View full text Add to dashboard Cite

Although atopic dry skin is believed to be caused by defects in skin genes important for maintaining skin barrier function, the role of sweat in atopic dermatitis (AD) has been apparently underestimated. Given the great capacity of sweat to maintain and increase skin hydration, defective sweating responses may be a logical place to look for changes that predispose individuals to the disease. We investigated how disease process and sweating defects progress from early asymptomatic stages to the onset of clinically apparent disease by employing the impression mould technique, which allows an accurate quantification of individual sweat gland/duct activity in relation to skin surface topography. Insensible and sensible sweating responses under baseline conditions and after thermal stimulus, respectively, were measured in various stages of AD patients and healthy controls. In controls, under baseline conditions, sweat ducts/glands at the dermal folds secreted basal levels of sweat (insensible sweating), thereby maintaining skin hydration. Not only such insensible sweating but also sensible sweating markedly decreased even in the earliest asymptomatic stage and the decrease was followed by compensatory hyperhidrosis at the ridge: leakage of sweat into the dermis could represent the initial event resulting in the decreased sweating and inflammation. The defects eventually progressed involving all of the ducts/glands to develop systemic dry skin. AD skin is characterized by varying degrees of functional impairment of sweat ducts/glands depending on the stage, and this defect would be among the reasons for the inability of AD patients to maintain skin hydration.

show abstract

“…Sweating is generally considered one of the most common trigger of itch in AD, 31 and increased sweating has been observed in AD patients with lichenified skin. 32 Acetylcholine and vasoactive intestinal peptide may play a role because both regulate sweat gland function and have been found to be increased in the skin of AD patients. 33 The main methods to manage this frequent trigger factor are avoidance of activities that lead to pronounced sweating or immediate washing and cooling after exercising.…”

Section: Identification and Elimination Of Trigger Factorsmentioning

confidence: 99%

Management of Itch in Atopic Dermatitis

Hong¹,

Buddenkotte²,

Berger³

et al. 2011

Seminars in Cutaneous Medicine and Surgery

132

105

View full text Add to dashboard Cite

Atopic dermatitis is a common, pruritic, inflammatory skin disorder. Chronic, localized, or even generalized pruritus is the diagnostic hallmark of atopic dermatitis, and its management remains a challenge for physicians. The threshold for itch and alloknesis is markedly reduced in these patients, and infections can promote exacerbation and thereby increase the itch. Modern management consists of anti-inflammatory, occasionally antiseptic, as well as antipruritic therapies to address the epidermal barrier as well as immunomodulation or infection. Mild forms of atopic dermatitis may be controlled with topical therapies, but moderate-to-severe forms often require a combination of systemic treatments consisting of antipruritic and immunosuppressive drugs, phototherapy, and topical compounds. In addition, patient education and a therapeutic regimen to help the patient cope with the itch and eczema are important adjuvant strategies for optimized long-term management. This review highlights various topical, systemic, and complementary and alternative therapies, as well as provide a therapeutic ladder for optimized long-term control of itch in atopic dermatitis.

show abstract

Differences in the Dynamics of Sweat Secretion in Atopic Children*

Cited by 25 publications

References 33 publications

Impaired sweating function in adult atopic dermatitis: results of the quantitative sudomotor axon reflex test

Impaired sweating function in adult atopic dermatitis: results of the quantitative sudomotor axon reflex test

A novel method to assess the potential role of sweating abnormalities in the pathogenesis of atopic dermatitis

Management of Itch in Atopic Dermatitis

Contact Info

Product

Resources

About