Differences in the expression of mucus-associated antigens between proximal and distal human colon adenocarcinomas

Bara, Jacques; Nardelli, Jeannette; Gadenne, C; Prade, M; Burtin, P

doi:10.1038/bjc.1984.77

Cited by 34 publications

(20 citation statements)

References 13 publications

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“…88 Mucinous carcinomas decrease in frequency by approximately 2.5-fold from the proximal to distal colon. 89,90 This is in line with the more frequent expression of mucin-associated M1 antigen in proximal (55%) compared to distal (13%) tumours. 89 Possibly the first report of a site-related molecular difference was the description in 1982 of a progressive increase in the incidence of aneuploidy from proximal to distal tumours.…”

Section: Morphologic and Molecular Differences Between Right And Leftsupporting

confidence: 63%

“…89,90 This is in line with the more frequent expression of mucin-associated M1 antigen in proximal (55%) compared to distal (13%) tumours. 89 Possibly the first report of a site-related molecular difference was the description in 1982 of a progressive increase in the incidence of aneuploidy from proximal to distal tumours. 91 This was followed by evidence for differential expression of the c-myc oncogene and the suggestion that it defined 2 genetically distinct forms of CRC.…”

Section: Morphologic and Molecular Differences Between Right And Leftsupporting

confidence: 63%

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Are there two sides to colorectal cancer?

Iacopetta

2002

Intl Journal of Cancer

695

558

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Colorectal carcinomas (CRC) that arise proximal (right) or distal (left) to the splenic flexure exhibit differences in incidence according to geographic region, age and gender. Together with observations that tumours in the hereditary cancer syndromes HNPCC and FAP occur predominantly in the right and left colon, respectively, the existence of 2 categories of CRC based on site of origin in the large bowel was proposed more than a decade ago. Differences between normal right and left colonic segments that could favour progression through different tumourigenic pathways are summarized in this review. Accumulating evidence suggests that the risk of CRC conferred by various environmental and genetic factors is different for proximal and distal tumours. Right-and left-sided tumours also exhibit different sensitivities to fluorouracil-based chemotherapy. Such differences are probably related to the molecular characteristics of the tumours, with the microsatellite instability and CpG island methylator phenotypes being associated with right-sided tumours and chromosomal instability with left-sided tumours. Future molecular-based classification systems for CRC that rely upon distinctive gene expression patterns may allow a clearer discrimination of subgroups than that provided by tumour site alone. Until then however, the existence of 2 broadly different groups of cancer defined by site of origin in the colon should be considered in the design of future epidemiologic studies as well as in the design of new clinical trials aimed at testing novel adjuvant therapies.

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Section: Morphologic and Molecular Differences Between Right And Leftsupporting

confidence: 63%

Section: Morphologic and Molecular Differences Between Right And Leftsupporting

confidence: 63%

Are there two sides to colorectal cancer?

Iacopetta

2002

Intl Journal of Cancer

695

558

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“…In contrast, the b and d epitopes were associated with a peak located near the '25I-IgG. DISCUSSION Ml antigens have been identified by their immunohistopathological pattern on human gastrointestinal tract; they have been shown to be associated with the cytoplasm of mucous cells of surface gastric epithelium, and have an oncofetal expression during colon carcinogenesis (Bara et al, 1980(Bara et al, , 1984Decaens et al, 1983). More recently Vol.…”

Section: A~~~0mentioning

confidence: 99%

Immunochemical characterization of mucins. Polypeptide (M1) and polysaccharide (A and Leb) antigens

Bara¹,

Gautier²,

Pendu

et al. 1988

Biochemical Journal

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Seven monoclonal antibodies (MAbs) reacting with high-molecular-mass components (greater than 20,000 kDa) isolated from an ovarian mucinous cyst of an A Le(a-b+) patient are described. By the use of immunoradiometric methods, these MAbs characterized seven different epitopes associated with components having a density of 1.45 g/ml by CsCl-density-gradient ultracentrifugation, like mucins. Two MAbs reacted with A and Lewis blood-group antigens respectively (polysaccharide epitopes). The five other MAbs characterized five M1 epitopes (called a, b, c, d and e), mainly associated with components of more than 20,000 kDa and 2000 kDa. They were completely destroyed by papain and 2-mercaptoethanol treatment (polypeptide epitopes). Moreover, timed trypsin digestion of native mucin resulted in a progressive loss of M1 activity and degraded these mucins into smaller M1-positive fragments. The a and c epitopes were partially degraded from relatively high-molecular-mass fragments (2000 kDa to 500 kDa) into a 100 kDa fragment. The b and d epitopes were completely degraded into smaller fragments ranging from 100 kDa to 40 kDa. The e epitope was completely destroyed by trypsin. These different pathways of M1 antigen degradation suggest the occurrence of different epitopes located in separate regions of the mucin molecules.

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“…For example, the mucin sulfate content is higher in the distal colon [14], and lectin binding also is site specific [15], As differentiation is lost during the devel opment of malignancy, most distal tumors begin to reexpress the blood group glycopro tein antigens A, B. H, and Leb [16]. In direct contrast, most proximal tumors lose these an tigens, even though they continue to be present in adjoining normal tissue [ 17], These differences also affect the mucin-associated antigens such as M 1 which are expressed w'ith differing frequencies in proximal (55%) and distal (12%) carcinomas [18]. Recent studies in our laboratory have shown significantly more cvclin D1 protein in left-than right sided colon tumors [19].…”

Section: Em Bryology and Geneticsmentioning

confidence: 99%

Are Right- and Left-Sided Colon Neoplasms Distinct Tumors?

Distler

Holt²

1997

Dig Dis

116

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Cancer of left and right colon has a differing prevalence at varying ages, in high- and low-incidence nations, as well as in men and in women. There also is a difference in clinical presentation, in prognosis, and possibly in genetic and environmental epidemiology. This review proposes that cancers of proximal and distal colon are different tumors because of their embryologic origin, genetic changes, and biologic identity. These factors are important in understanding the ‘shift of tumors from more distal to more proximal sites in the colon’ and in evaluating potential suggestions for instituting advances in diagnosis and prevention.

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Differences in the expression of mucus-associated antigens between proximal and distal human colon adenocarcinomas

Cited by 34 publications

References 13 publications

Are there two sides to colorectal cancer?

Are there two sides to colorectal cancer?

Immunochemical characterization of mucins. Polypeptide (M1) and polysaccharide (A and Leb) antigens

Are Right- and Left-Sided Colon Neoplasms Distinct Tumors?

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