Differences in the Measurement of Functional Residual Capacity Between Body Plethysmographs of Two Manufacturers

Alter, Peter; Orszag, Jan; Wouters, Emiel F.M.; Vogelmeier, Claus; Jörres, Rudolf A.

doi:10.2147/copd.s363493

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…For example, in GLI devices manufactured by JAEGER (which we used in our study) measured somewhat higher values than those from other manufacturers, especially for RV [ 6 ]. Recently, authors from COSYCONET demonstrated differences in FRC up to 0.67 L between two manufacturers [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Updated reference values for static lung volumes from a healthy population in Austria

Mraz,

Asgari,

Karimi

et al. 2024

Respir Res

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Background Reference values for lung volumes are necessary to identify and diagnose restrictive lung diseases and hyperinflation, but the values have to be validated in the relevant population. Our aim was to investigate the Global Lung Function Initiative (GLI) reference equations in a representative healthy Austrian population and create population-derived reference equations if poor fit was observed. Methods We analysed spirometry and body plethysmography data from 5371 respiratory healthy subjects (6–80 years) from the Austrian LEAD Study. Fit with the GLI equations was examined using z-scores and distributions within the limits of normality. LEAD reference equations were then created using the LMS method and the generalized additive model of location shape and scale package according to GLI models. Results Good fit, defined as mean z-scores between + 0.5 and -0.5,was not observed for the GLI static lung volume equations, with mean z-scores > 0.5 for residual volume (RV), RV/TLC (total lung capacity) and TLC in both sexes, and for expiratory reserve volume (ERV) and inspiratory capacity in females. Distribution within the limits of normality were shifted to the upper limit except for ERV. Population-derived reference equations from the LEAD cohort showed superior fit for lung volumes and provided reproducible results. Conclusion GLI lung volume reference equations demonstrated a poor fit for our cohort, especially in females. Therefore a new set of Austrian reference equations for static lung volumes was developed, that can be applied to both children and adults (6–80 years of age).

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Section: Discussionmentioning

confidence: 99%

Updated reference values for static lung volumes from a healthy population in Austria

Mraz,

Asgari,

Karimi

et al. 2024

Respir Res

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“…As body plethysmographs are not subjected to the same strict requirements of comparability as commercial spirometers, the difference observed could also be due to a bias in the assessment of static lung volumes. For example, when comparing a plethysmograph of the brand that we used with that of another manufacturer, we previously found systematic differences of about 0.67 L in TLC in patients with COPD [ 20 ]. It is intriguing that in the study by O’Donnell and co-workers [ 21 ] body plethysmographic TLC appeared to be shifted upwards by about 0.5 to 1 L compared to CT-based values of TLC.…”

Section: Discussionmentioning

confidence: 99%

The total-breath method yields higher values of DLCO and TLC than the conventional method

Jörres,

Buess,

Piecyk

et al. 2024

BMC Pulm Med

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Background The 2017 ATS/ERS technical standard for measuring the single-breath diffusing capacity (DLCO) proposed the “rapid-gas-analyzer” (RGA) or, equivalently, “total-breath” (TB) method for the determination of total lung capacity (TLC). In this study, we compared DLCO and TLC values estimated using the TB and conventional method, and how estimated TLC using these two methods compared to that determined by body plethysmography. Method A total of 95 people with COPD (GOLD grades 1–4) and 23 healthy subjects were studied using the EasyOne Pro (ndd Medical Technologies, Switzerland) and Master Screen Body (Vyaire Medical, Höchberg, Germany). Results On average the TB method resulted in higher values of DLCO (mean ± SD Δ = 0.469 ± 0.267; 95%CI: 0.420; 0.517 mmol*min-1*kPa-1) and TLC (Δ = 0.495 ± 0.371; 95%CI: 0.427; 0.562 L) compared with the conventional method. In healthy subjects the ratio between TB and conventional DLCO was close to one. TLC estimated using both methods was lower than that determined by plethysmography. The difference was smaller for the TB method (Δ = 1.064 ± 0.740; 95%CI: 0.929; 1.199 L) compared with the conventional method (Δ = 1.558 ± 0.940; 95%CI: 1.387; 1.739 L). TLC from body plethysmography could be estimated as a function of TB TLC and FEV1 Z-Score with an accuracy (normalized root mean square difference) of 9.1%. Conclusion The total-breath method yielded higher values of DLCO and TLC than the conventional analysis, especially in subjects with COPD. TLC from the total-breath method can also be used to estimate plethysmographic TLC with better accuracy than the conventional method. The study is registered under clinicaltrial.gov NCT04531293.

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“…Wenn man die paradoxe Schlussfolgerung vermeiden möchte, dass adipöse Patienten mit COPD gegenüber normalgewichtigen Patienten eine vermehrte statt eine verminderte Lungenüberblähung zeigen, sind nur Sollwerte angemessen, die nicht für die Reduktion der FRC bei hohem Körpergewicht korrigieren. Eine weitere Beobachtung war, dass die Ganzkörperplethysmografen zweier Hersteller unterschiedliche Messwerte für FRC ergaben; diese Tatsache dürfte bei der diagnostischen Bewertung sowie bei multizentrischen Studien nicht ohne Bedeutung sein 45 . Es ist bekannt, dass die Werte der Diffusionskapazität für CO gut mit dem Ausmaß eines Emphysems gemäß CT korrelieren.…”

Section: Ergebnisseunclassified

Was haben wir aus der deutschen COPD-Kohorte COSYCONET gelernt und wie geht es weiter?

et al. 2022

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ZusammenfassungCOSYCONET 1 ist die derzeit einzige international konkurrenzfähige deutsche COPD-Kohorte. Die Rekrutierung begann Ende 2010 und endete im Dezember 2013. Sie resultierte in 2741 Patienten mit der Diagnose einer COPD, die in der Folge in regelmäßigen Visiten nachuntersucht wurden. Diese Visiten umfassten eine umfangreiche funktionelle und klinische Charakterisierung. Auf der Basis dieses hochwertigen Datensatzes war es möglich, eine Vielzahl klinischer Fragen zu beantworten. Diese reichten vom Verschreibungsverhalten über die genaue Analyse verschiedener Komorbiditäten, v.a. kardiovaskulärer Art, bis zu Biomarkern, radiologischen und gesundheitsökonomischen Analysen. Inzwischen wurden mehr als 60 Publikationen zu COSYCONET international veröffentlicht. Die nachstehende Arbeit liefert eine Übersicht über alle bislang erhaltenen Ergebnisse, mit einem besonderen Fokus darauf, deren wechselseitigen Zusammenhang sowie die möglichen praktischen Konsequenzen herauszuarbeiten. Ferner werden einige Informationen über die Folgestudie COSYCONET 2 gegeben.

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Differences in the Measurement of Functional Residual Capacity Between Body Plethysmographs of Two Manufacturers

Cited by 4 publications

References 9 publications

Updated reference values for static lung volumes from a healthy population in Austria

Updated reference values for static lung volumes from a healthy population in Austria

The total-breath method yields higher values of DLCO and TLC than the conventional method

Was haben wir aus der deutschen COPD-Kohorte COSYCONET gelernt und wie geht es weiter?

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