Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study

Forouhi, Nita G.; Koulman, Albert; Sharp, Stephen J.; Imamura, Fumiaki; Kröger, Janine; Schulze, Matthias B.; Crowe, Francesca L.; Huerta, José María; Guevara, Marcela; Beulens, Joline W.J.; Woudenbergh, Geertruida J. van; Wang, Laura; Summerhill, Keith; Griffin, Julian L.; Feskens, Edith J. M.; Amiano, Pilar; Clavel‐Chapelon, Françoise; Dartois, Laureen; Fagherazzi, Guy; Franks, Paul W.; González, Carlos; Jakobsen, Marianne Uhre; Kaaks, Rudolf; Key, Timothy J.; Khaw, Kay Tee; Kühn, Tilman; Mattiello, Amalia; Nilsson, Peter M.; Overvad, Kim; Pala, Valeria; Palli, Domenico; Quirós, J. Ramón; Rolandsson, Olov; Roswall, Nina; Sacerdote, Carlotta; Sánchez, María José; Slimani, Nadia; Spijkerman, Annemieke M.W.; Tjønneland, Anne; Tormo, María José; Tumino, Rosario; A, Daphne L. van der; Schouw, Yvonne T. van der; Langenberg, Claudia; Riboli, Elio; Wareham, Nicholas J.

doi:10.1016/s2213-8587(14)70146-9

Cited by 477 publications

(467 citation statements)

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“…Overall, the estimated D6D and SCD1 activities were strongly associated and the estimated D5D activity was inversely associated with the development of type 2 diabetes, as previously reported [14,27]. We also showed that the most abundant SFAs were associated with an elevated risk of diabetes, in agreement with two recent studies showing associations with type 2 diabetes [17,28]. Total SFAs were associated with impaired insulin sensitivity and insulin secretion in our study, offering a mechanistic explanation for how SFAs may impair glucose tolerance and lead to type 2 diabetes.…”

Section: Discussionsupporting

confidence: 91%

“…Odd chain fatty acids (15:0 and 17:0) were not associated with impaired insulin sensitivity or insulin secretion. Evidence in earlier studies also suggests an inverse association of pentadecanoic acid 15:0 and margaric acid 17:0 with the risk of type 2 diabetes [15,28,32]. Odd chain fatty acids are found in milk fat and fish [33][34][35][36].…”

Section: Discussionmentioning

confidence: 90%

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Plasma fatty acids as predictors of glycaemia and type 2 diabetes

et al. 2015

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Aims/hypothesis Our aim was to investigate the fasting proportions of fatty acids and estimated desaturase and elongase activities in three different lipid fractions in plasma, phospholipids (PLs), cholesteryl esters (CEs) and triacylglycerols (TGs), as predictors for the worsening of glycaemia (area under the glucose curve in an OGTT [glucose AUC]) and incident type 2 diabetes in a 5.9 year follow-up of the Metabolic Syndrome in Men population-based cohort. Methods Fatty acid proportions were measured in plasma PL, CE and TG fractions in 1,364 Finnish men aged 45-68 years at baseline. The prospective follow-up study included only men who were non-diabetic at baseline and had data available at follow-up (n=1,302). A total of 71 participants developed new type 2 diabetes during follow-up.Results After adjusting for confounding factors, total saturated fatty acids, palmitoleic acid (16:1n-7), dihomo-γ-linolenic acid (20:3n-6) and estimated stearoyl-CoA desaturase 1 and Δ 6 -desaturase (D6D) enzyme activities significantly predicted the worsening of glycaemia whereas total polyunsaturated fatty acid, linoleic acid (18:2n-6) and elongase activity predicted a decrease in the glucose AUC. Estimated D6D activity and dihomo-γ-linolenic acid (20:3n-6) were associated with an increased risk of incident type 2 diabetes. Results were consistent across the three different lipid fractions. However, fatty acid proportions in the PL and CE fractions were stronger predictors for glycaemia and incident type 2 diabetes compared with fatty acid proportions in the TG fraction. Conclusions/interpretation Selected fatty acid proportions of plasma lipid fractions and their ratios, which reflect desaturase and elongase enzyme activities, may be good biomarkers for the worsening of glycaemia and incident type 2 diabetes.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 90%

Plasma fatty acids as predictors of glycaemia and type 2 diabetes

et al. 2015

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“…Rate of stricture in RFA procedure 9% - [19] Rate of perforation in RFA procedure 0.1% Clinical expert opinion -Mortality from esophagectomy 4.3% - [16] All-cause mortality Dependent on starting age and cycle in the model - [33] EMR: Endoscopic mucosal resection; HGD: High-grade dysplasia;…”

Section: Safety Inputsmentioning

confidence: 99%

Cost–effectiveness analysis of endoscopic eradication therapy for treatment of high-grade dysplasia in Barrett’s esophagus

et al. 2017

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Aim:The aim was to evaluate the cost-effectiveness of endoscopic eradication therapy (EET) with combined endoscopic mucosal resection and radiofrequency ablation for the treatment of high-grade dysplasia (HGD) arising in patients with Barrett's esophagus compared with endoscopic surveillance alone in the UK. Materials & methods:The cost-effectiveness model consisted of a decision tree and modified Markov model. A lifetime time horizon was adopted with the perspective of the UK healthcare system. Results: The base case analysis estimates that EET for the treatment of HGD is cost-effective at a GB£20,000 cost-effectiveness threshold compared with providing surveillance alone for HGD patients (incremental cost-effectiveness ratio: GB£1272). Conclusion: EET is likely to be a cost-effective treatment strategy compared with surveillance alone in patients with HGD arising in Barrett's esophagus in the UK. Barrett's esophagus (BE) is a precancerous state that can develop into esophageal adenocarcinoma (OAC). BE exists in most patients in a metaplastic state and carries a very low risk of progression to invasive neoplasia and OAC in the region of 0.12-0.5% per year [1,2]. The 2013 British Society of Gastroenterology (BSG) guidelines advise that, in those patients with BE in whom there is no neoplasia, surveillance is recommended for those fit for endoscopy [3]. This is based on existing evidence from published studies which show that surveillance correlates with early-stage cancer diagnosis and likely improved survival from other cancers [4][5][6]. Recent work from the ProBar study group examined data from the Dutch cancer registry. They compared survival of patients with BE with neoplastic progression during surveillance with those of patients without neoplastic progression and patients with OAC in the general population. They found that OAC was diagnosed at an earlier stage during BE surveillance than in the general population. However, the survival of patients with BE with neoplastic progression was not significantly worse than those of patients without neoplastic progression, and was similar to survival of patients with stage 0 or stage 1 OAC in the general population [7]. In patients with OAC, the prognosis is poor with just over 15% patients being alive at 5 years [8].Current UK surveillance guidelines [3] recommend that patients with BE undergo endoscopy every 2-5 years. In some patients, no surveillance is recommended due to the negligible risk for cancer progression. The intervals are dependent on the length of BE and presence of intestinal metaplasia at the index endoscopy. However, in a minority of patients with BE there is a molecular and pathological transformation through various dysplastic stages to mucosal dysplasia and cancer and then finally invasive disease where it Cost-effectiveness analysis of endoscopic eradication therapy for treatment of highgrade dysplasia in Barrett's esophagus

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“…The mechanism of the inhibitory role of C15:0 on proliferation of cancerous cells is similar to that of CLA. The intake of odd-chain saturated fatty acids is also related to a reduced incidence of type II diabetes in humans (Forouhi et al, 2014). Thus, further studies are needed to evaluate the effects of crude glycerin on the synthesis and biohydrogenation of fatty acids and rumen bacteria involved in this process, in order to obtain meat with healthier fatty acid profile for human consumption.…”

Section: Resultsmentioning

confidence: 99%

Carcass traits and meat quality of Nellore cattle fed different non-fiber carbohydrates sources associated with crude glycerin

Fávaro

Almeida

D’Áurea

et al. 2016

Animal

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Crude glycerin, a potential energy source for ruminant animals, has been evaluated, mainly, in diets with high starch content. However, a limit number of studies have evaluated the inclusion of crude glycerin in low starch diets. This study aimed to evaluate the effects of the association of crude glycerin with corn grain or citrus pulp on carcass traits and meat quality of Nellore bulls ( n = 30, 402 ± 31 kg initial weight). The treatment consisted of: CON = control, without crude glycerin; CG10 = 10% of crude glycerin and corn grain; CG15 = 15% of crude glycerin and corn grain; CP10 = 10% of crude glycerin and citrus pulp; CP15 = 15% of crude glycerin and citrus pulp. The performance parameters and carcass traits were not affected by treatments ( P > 0.05). The inclusion of crude glycerin decreased yellow color intensity and increased fatty acids pentadecanoic and heptadecenoic in meat ( P < 0.05), without affecting neither the concentration of polyunsaturated fatty acids nor the relationship of saturated and unsaturated fatty acids. The association of crude glycerin with corn or citrus pulp has no adverse effects on carcass characteristics and meat quality.

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Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study

Cited by 477 publications

References 30 publications

Plasma fatty acids as predictors of glycaemia and type 2 diabetes

Plasma fatty acids as predictors of glycaemia and type 2 diabetes

Cost–effectiveness analysis of endoscopic eradication therapy for treatment of high-grade dysplasia in Barrett’s esophagus

Carcass traits and meat quality of Nellore cattle fed different non-fiber carbohydrates sources associated with crude glycerin

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