Differences in the time course of the effects of oophorectomy in women on parameters of bone metabolism and interleukin-1 levels in the circulation

Fiore, Carmelo Erio; Falcidia, E; Foti, Rosario; Motta, Massimo; Tamburino, C

doi:10.1016/s0169-6009(08)80039-6

Cited by 26 publications

(11 citation statements)

References 17 publications

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“…In this study we have also found that the infusion of IL-Ira resulted in serum IL-lra levels 16 times higher than that required to block 45Ca release in vitro from mouse bone stimulated with 100 pg/ml of IL-1 (28) and that the injection of TNFbp resulted is serum type I TNF receptor levels 5-10 times higher than the amount of recombinant TNFa required to stimulate bone resorption in vitro (15). Assays of cytokines in the culture media of bone marrow cells revealed that ovx is associated with an increased production of IL-1 and TNF, a finding in keeping with previous rat and human studies of ours and others (30,31,33,34,37,55) but in contrast with those Hustmyer et al (56) and Zarrabeitia et al (57) who failed to detect a higher production of IL-1 and TNF in osteoporotic women. We also found that ovx was not associated with an increased bone marrow cell production of IL-6.…”

Section: Discussionsupporting

confidence: 64%

Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice.

Kitazawa

Kimble²,

Vannice³

et al. 1994

J. Clin. Invest.

318

211

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To investigate the contribution of IL-1, IL-6, and TNF to the increased osteoclastogenesis induced by estrogen deficiency, ovariectomized (ovx) mice were treated with either IL-1 receptor antagonist (IL-lra), a competitive inhibitor of IL-1, TNF binding protein (TNFbp), an inhibitor of TNF, or the anti-IL-6 antibody (Ab) 20F3 for the first 2 wk after surgery. ovx increased the bone marrow cells secretion of IL-1 and TNF, but not IL-6, and the formation of TRAPpositive osteoclast-like multinucleated cells (MNCs) in bone marrow cultures treated with 1,25(OH)2D3. The increase in MNC formation induced by ovx was prevented by in vivo treatment with either 17/8 estradiol, IL-lra, TNFbp, or anti-IL-6 Ab. However, the percent change in MNC formation induced by the anti-IL-6 Ab was similar in ovx and shamoperated animals, whereas IL-lra and TNFbp were effective only in ovx mice. MNC formation was also decreased by in vitro treatment of bone marrow cultures with IL-lra and TNFbp, but not with anti-IL-6 Ab. Ovx also increased bone resorption in vivo and in vitro, as assessed by the urinary excretion of pyridinoline cross links and the formation of resorption pits, respectively. IL-lra, TNFbp and estrogen decreased bone resorption in vivo and in vitro whereas the anti-IL-6 Ab inhibited bone resorption in vitro but not in vivo. In conclusion, these data indicate that IL-1 and TNF play a direct role in mediating the effects of ovx on osteoclastogenesis and bone resorption. The data also suggest that IL-6 is not essential for increasing bone resorption in the early postovariectomy period. (J. Clin. Invest. 1994.

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Section: Discussionsupporting

confidence: 64%

Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice.

Kitazawa

Kimble²,

Vannice³

et al. 1994

J. Clin. Invest.

318

211

View full text Add to dashboard Cite

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“…The best studied clinical area is that of postmenopausal osteoporosis, in which estrogen deficiency, whether natural or surgical, has been associated with increased peripheral blood monocyte production of IL-1␤, IL-6, TNF-␣, and colony-stimulating factors (27). The changes in these cytokines occur in a temporal sequence, suggesting that they have a causal role in the pathogenesis of ovariectomy-induced bone loss (28). Furthermore, the bone-resorbing activity of the supernatants of cultured peripheral blood monocytes obtained from both pre-and postmenopausal women has been correlated with supernatant IL-1, IL-6, and TNF-␣ levels and with total pyridinoline excretion (29).…”

Section: Discussionmentioning

confidence: 99%

“…The relatively low r values for these associations is probably due to the complexity of the underlying pathophysiology, in which multiple mediators might affect bone metabolism in a variety of ways. In addition, a number of other (unmeasured) factors, including, but not limited to, sex hormones, colony stimulating factors (e.g., macrophage colony-stimulating factor and granulocyte-macropahge colonystimulating factor), IL-6-like cytokines (e.g., IL-11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, cardiotrophin-1), and IL-17 may be related to the changes in bone metabolic markers (10)(11)(12)28). Second, both the exacerbation of pulmonary infection and the response to therapy are heterogeneous processes in CF.…”

Section: Discussionmentioning

confidence: 99%

Adverse Alterations in Bone Metabolism Are Associated with Lung Infection in Adults with Cystic Fibrosis

Aris

Stephens

Ontjes

et al. 2000

Am J Respir Crit Care Med

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Low bone density, fractures, and kyphosis complicate the lives of adults with cystic fibrosis (CF), and inflammatory cytokines (interleukin [IL]-1beta, IL-6, and tumor necrosis factor [TNF]-alpha) that may alter bone metabolism have been previously found to be increased in the lungs and serum of CF patients. The objective of this prospective study was to determine the impact of lung infection on bone physiology in 17 adult CF patients. Serum osteocalcin, a marker of bone formation; urine N-telopeptides of type I collagen and free deoxypyridinoline, both of which are markers of bone breakdown; serum cytokines (TNF-alpha, IL-1beta, and IL-6); and general inflammatory markers (serum C-reactive protein [CRP] and chondrex) were measured at the beginning and end of treatment for an acute exacerbation of lung infection and again 3 wk later. After treatment with conventional antibiotics, decreases in N-telopeptides (147.3 +/- 77.5 [mean +/- SEM] versus 95.5 +/- 57.3 bone collagen equivalents (BCE)/mmol creatinine, p = 0.0014), deoxypyridinoline (8.42 +/- 2.8 versus 6.8 +/- 3.0 mmol/mmol creatinine, p = 0.08), IL-1beta (1.43 +/- 1.13 versus 0.65 +/- 0.63 pg/ml, p = 0.03), IL-6 (9.5 +/- 6.5 versus 4.7 +/- 3.2 pg/ml, p = 0. 012), CRP (43.1 +/- 29.3 versus 23.4 +/- 25.3 mg/ml, p = 0.04), and chondrex (151.7 +/- 111.7 versus 101.4 +/- 67.3 ng/ml, p = 0.014), and increases in osteocalcin levels (14.5 +/- 5.4 versus 22.5 +/- 8. 7 ng/ml, p = 0.010) were observed. Three weeks later, the changes in N-telopeptides and osteocalcin persisted. These data indicate that pulmonary infection, through the elaboration of inflammatory cytokines, may be linked to increased bone resorption and diminished bone formation. These results provide insights into the impact of systemic inflammation on bone health, and suggest novel mechanisms for bone disease in CF.

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“…Reduced (3)(4)(5), increased (6,7) and unchanged bone mineral density were seen in the studies (8)(9)(10). The increased bone resorption markers after the bilateral hysterectomy and oophorectomy revealed by Fiore CE and et al (11) showed that there was no negative effect of ovaries protective hysterectomy on osteoporosis.…”

Section: Introductionmentioning

confidence: 74%

Relationship of Bone Densitometry and Bone Resorption Markers With Menopausal Type and Duration

et al. 2010

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Objective: Menopause age and bone mineral density are positively related and there is a rapid bone loss in the early postmenopausal period. A ratio of 30% of post-menopausal women are affected from osteoporosis developing due to bone loss and this causes 40% risk of fracture in a 50-year old woman. Materials and Methods: In this sudy, serum osteocalcin and urine deoxypridinoline levels were analyzed in 102 postmenapausal and 48 healthy premenopausal controls who presented to gynecology outpatient clinic. Bone densitometry was obtained from all postmenopausal women. Postmenopausal patients were further divided into four groups according to time since menopause: <5 years, 5-9 years, 10-19 years and >20 years. Results: Mean (SD) age in 48 premenopausal women was 47.7 (3.7) while it was 56.5 (6.8) in 102 post-menopausal women. 34 out of 102 post-menopausal women had surgical menopause due to bilateral oopheroctomy+hysterectomy while the remaining had natural menopause. No significant difference was found in bone-turnover markers between women with surgical and natural menopause. Conclusion: Although there was not a statistically significant difference between bone-turnover markers, bone mineral density stays lower in surgical menopausal patients and this difference disappear only after about 20 years. Also bone turnover markers are usually high up to five years after surgical menopause and return to normal levels after then. Thus, our study suggested that oopheroctomy does not cause additional risk to hysterectomy. We also suggest that there is not a longterm relationship between serum bone turnover markers or bone density and the etiology of menopause. (Turk J Rheumatol 2010; 25: 29-33

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Differences in the time course of the effects of oophorectomy in women on parameters of bone metabolism and interleukin-1 levels in the circulation

Cited by 26 publications

References 17 publications

Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice.

Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice.

Adverse Alterations in Bone Metabolism Are Associated with Lung Infection in Adults with Cystic Fibrosis

Relationship of Bone Densitometry and Bone Resorption Markers With Menopausal Type and Duration

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