Background: Oxidative stress has been implicated as a part of the pathophysiological mechanisms of Schizophrenia. Oxidative stress occurs due to the imbalance of antioxidants and oxidants. Glutathione is one of the primary antioxidants that contribute to the oxidative-stress-preventable mechanism. The correlation between oxidative stress, glutathione deficiency, and schizophrenic pathophysiology has been reported in previous clinical studies. The reduction of glutathione, particularly in schizophrenic symptomatology (especially in negative and positive symptoms), has been characterized.
Methods:A cross-sectional study recruited 48 Bataknese males with Schizophrenia who have been administered atypical antipsychotic medications for at least a year. The glutathione levels were measured by the ELISA Method to calculate the quantitative results of GSH concentration within the blood plasm in vitro. The severity of symptoms was characterized via the Positive and Negative Syndrome Scale (PANSS).Results: Our study found a significant correlation between glutathione levels and the severity of symptoms of Schizophrenia (p<0.05). The Pearson correlation value was -0.587, a negative value with medium correlation strength.
Conclusion:Our findings support the fact that oxidative stress is one of the pathophysiological mechanisms of Schizophrenia. This study also showed that a low glutathione level is associated with the severity of symptoms of Bataknese males with Schizophrenia.