Differences of Intrasession Reproducibility of Circumpapillary Total Retinal Thickness and Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements Made with the RS-3000 Optical Coherence Tomograph

Kita, Yoshiyuki; Holló, Gábor; Kita, Ritsuko; Horie, Daisuke; Inoue, Makoto; Hirakata, Akito

doi:10.1371/journal.pone.0144721

Cited by 16 publications

(14 citation statements)

References 29 publications

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“…The retinal structure in eyes with ONH has been studied using optical coherence tomography (OCT) 8 9 10 and histopathologic analysis 2 11 12 , with the focus on the ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL). Pathological studies have reported a significant reduction in the thicknesses of the GCL and RNFL in eyes with ONH 2 11 12 , and these findings have been confirmed non-invasively in vivo by OCT measurements 8 9 10 with excellent reproducibility 13 .…”

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confidence: 76%

Retinal Structure and Function in Eyes with Optic Nerve Hypoplasia

Katagiri

Nishina

Yamaguchi

et al. 2017

Sci Rep

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We investigated retinal structure and function in eyes with optic nerve hypoplasia (ONH). Twenty-nine eyes of 18 patients with ONH and 21 eyes of 21 control patients were analyzed. Spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (FF-ERG), and focal macular ERG (FM-ERG) were performed. SD-OCT analysis of the macular region showed significant ganglion cells complex (GCC) thinning nasally and temporally (P < 0.05), but the thickness from the inner nuclear layer (INL) to the retinal pigment epithelium (RPE) became thinner only nasally (P < 0.05). SD-OCT analysis of the circumpapillary region showed significant thinning in the retinal nerve fiber layer and from the INL to the RPE (P < 0.05). The horizontal SD-OCT images showed variable foveal abnormalities. FF-ERG analysis showed significantly reduced amplitudes (P < 0.05) and preserved implicit time in the photopic negative response. The amplitudes and implicit times of the other FF-ERG components did not differ significantly. FM-ERG analysis showed significantly reduced amplitudes (P < 0.05) but preserved implicit times in all components. The current study showed the change of retinal structure and function in eyes with ONH compared with those with control, representing by decreased retinal ganglion cells (RGCs) and their axons, foveal abnormalities, and preserved peripheral retina except for the RGCs and their axons.

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confidence: 76%

Retinal Structure and Function in Eyes with Optic Nerve Hypoplasia

Katagiri

Nishina

Yamaguchi

et al. 2017

Sci Rep

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“…The thickness of the combined inner retinal layers, known as the ganglion cell complex (GCC), includes the retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer 32 . Moreover, circumpapillary retinal nerve fibers (cpRNFLs) were also measured 33 . A glaucomatous VF loss was defined as MD and PSD with p<0.05, and a cluster in the pattern standard deviation plot of at least 3 points with p<0.05, one of each with p<0.01, not contiguous with the blind spot and not crossing the horizontal midline.…”

Section: Study Populationmentioning

confidence: 99%

Serum Brain-Derived Neurotrophic Factor in Glaucoma Patients in Japan: An Observational Study

et al. 2020

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Purpose. The aim of this study was to measure the serum levels of brain-derived neurotrophic factor (BDNF) in primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients in Japan. Methods. This was a prospective, observational study that examined serum BDNF levels in 78 patients who underwent cataract surgery or trabeculectomy (27 glaucoma patients and 51 non-glaucoma cataract patients as controls). The patients' age was 68.8 ± 11.1 years (mean ± standard deviation; range 35-86 years). The number of patients with POAG and NTG was 16 and 11, respectively. The diagnosis of POAG was done by intraocular pressure measurement, gonioscopy, optic nerve head change, and the presence of a visual field defect. Results. The serum BDNF concentration was significantly lower in the glaucoma group, including both POAG and NTG, than in the control group (7.2 ± 3.6 ng/mL vs. 12.2 ± 9.3 ng/mL, p=0.004). The serum BDNF concentration was lower in the early phase than in the moderate phases of glaucoma. There was no correlation between the serum BDNF concentration and age. When the NTG and POAG patient groups were compared, the serum BDNF concentration was lower in NTG patients than in POAG patients. No significant correlations were found between glaucoma parameters, including optical coherence tomography and visual field defects, and the serum BDNF concentration. Conclusion. This is the first study to have investigated serum BDNF concentrations in glaucoma patients in Japan. Further investigations are needed to evaluate the role of BDNF as a potential biomarker of glaucoma.

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“…When these two parameters were combined, the glaucoma detection rate increased to 83%. In previous investigations, the cpTR thickness exhibited a high reproducibility,[24] and when using the Spectralis OCT, had an even higher diagnostic accuracy for glaucoma than the cpRNFL thickness. [30] In the current investigation, the AUROC for cpTR thickness was higher than that of the cpRNFL thickness although the difference was not statistically significant.…”

Section: Discussionmentioning

confidence: 98%

“…To further improve the diagnostic accuracy of SD-OCT technology, various novel SD-OCT parameters for their clinical usefulness in glaucoma diagnostics were investigated. [202122232425] Recently, Kita et al . have shown that the reproducibility of the circumpapillary total retina (cpTR) thickness is higher than that of the cpRNFL thickness[24] and that the ratio of mGCC thickness to macular outer retinal thickness (G/O ratio) has significantly higher diagnostic accuracy than cpRNFL thickness in Japanese eyes.…”

mentioning

confidence: 99%

“…[202122232425] Recently, Kita et al . have shown that the reproducibility of the circumpapillary total retina (cpTR) thickness is higher than that of the cpRNFL thickness[24] and that the ratio of mGCC thickness to macular outer retinal thickness (G/O ratio) has significantly higher diagnostic accuracy than cpRNFL thickness in Japanese eyes. [17202325] These results show that new SD-OCT parameters may offer additional benefits in glaucoma diagnostics.…”

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confidence: 99%

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Circumpapillary ganglion cell complex thickness to diagnose glaucoma: A pilot study

Kita

Soutome

Horie

et al. 2017

Indian J Ophthalmol

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Purpose:The purpose of this study is to evaluate the applicability of a new optical coherence tomography parameter, the circumpapillary ganglion cell complex (cpGCC) thickness for glaucoma diagnostics.Subjects and Methods:The RS-3000 Advance SD-OCT (NIDEK, Aichi, Japan) was used to measure global and sector macular GCC (mGCC) thickness, circumpapillary retinal nerve fiber layer (cpRNFL) thickness, cpGCC, and circumpapillary total retina (cpTR) thickness in 1 eye of 48 preperimetric/early perimetric primary open-angle glaucoma patients and 28 healthy Japanese participants. Area under the receiver-operating characteristic (AUROC) curves were used for between-method comparisons.Results:All global and sector parameters except for the nasal sector differed significantly between the patient groups (P ≤ 0.009). The AUROC for global mGCC (0.917) was significantly higher (P < 0.01) than that for global cpRNFL (0.760), global cpGCC (0.828), and global cpTR (0.812). The AUROC values of global and temporal cpGCC were significantly higher than those of the corresponding cpRNFL parameters (P < 0.05). Correlation between the visual field means deviation and each of the global thickness parameters was similar (r: 0.418–0.473, P < 0.001). At >90% specificity, the cpGCC, cpTR, and cpRNFL were able to detect 4%, 10%, and 0% of glaucoma eyes that were not detected by the mGCC thickness.Conclusions:In Japanese eyes, the diagnostic accuracy of cpGCC is lower than that of mGCC but higher than that of cpRNFL. Our results suggest that the use of cpGCC may not improve glaucoma diagnostics when there is no macular disease but may be of benefit when macular diseases prevent successful mGCC measurements.

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Differences of Intrasession Reproducibility of Circumpapillary Total Retinal Thickness and Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements Made with the RS-3000 Optical Coherence Tomograph

Cited by 16 publications

References 29 publications

Retinal Structure and Function in Eyes with Optic Nerve Hypoplasia

Retinal Structure and Function in Eyes with Optic Nerve Hypoplasia

Serum Brain-Derived Neurotrophic Factor in Glaucoma Patients in Japan: An Observational Study

Circumpapillary ganglion cell complex thickness to diagnose glaucoma: A pilot study

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