Differences of Mortality Rates between Pocket and Nonpocket Cardiovascular Implantable Electronic Device Infections

Lee, Dong Heun; Gracely, Edward J.; Aleem, Sarah Y.; Kutalek, Steven P.; Vielemeyer, Ole

doi:10.1111/pace.12748

Cited by 27 publications

(24 citation statements)

References 24 publications

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“…Preoperative antibiotic therapy duration may be seen as a surrogate of time from diagnosis to extraction. One can thus suggest that these results support the dogma that extraction should be performed as swiftly as possible after a CIED infection has been confirmed …”

Section: Discussionsupporting

confidence: 67%

Thrombocytopenia and end stage renal disease are key predictors of survival in patients with cardiac implantable electronic device infections

Herrmann

Ehrenfeld

Wellmann

et al. 2019

Cardiovasc electrophysiol

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Introduction: Cardiac implantable electronic device (CIED) infections are associated with a high mortality. Our aim was to identify key predictors of survival in patients with CIED infections as to be able to detect high-risk patients and possibly affect modifiable factors. Methods and Results: In this observational study, we collected data from 277 patients with CIED infections treated in our department between 2001 and 2017; predictors of survival were evaluated. The median time since the last CIED procedure was 0.83 years (interquartile range [IQR]: 0.25-3.01), median time since initial CIED implant was 4.79 years (IQR: 0.90-11.0 years). Survival at 30 days was 94.9% (95% confidence interval [CI]: 92.3-97.5) and survival at 1 year was 80.9% (CI: 76.4-85.7).

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Section: Discussionsupporting

confidence: 67%

Thrombocytopenia and end stage renal disease are key predictors of survival in patients with cardiac implantable electronic device infections

Herrmann

Ehrenfeld

Wellmann

et al. 2019

Cardiovasc electrophysiol

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“…It has been observed that 45% patients with S. aureus in their blood cultures developed infection in a year. After a year, S. aureus related infections were scarcely reported [31]. Taking this into account, it has been recommended that the moment S. aureus is detected the whole PM/ICD/CRT device be removed instantly, irrespective of clinical manifestations or vegetations found in echocardiographic examination.…”

Section: Discussionmentioning

confidence: 99%

Etiology, Clinical Manifestations and Microbiological Profile of Cardiac Device Infections

Montewka¹,

Wysokiński²

2016

Clin Microbiol

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Introduction: Cardiovascular implantable electronic device infections (CIEDIs) cause a lot of serious clinical problems among which lead dependent infective endocarditis (LDIE) is considered to be the worst. Background: The background of the study was to analyze the parameters of clinical manifestations, determine the etiology and microbiological profile of the infections as well as evaluate the role of echocardiography in diagnosing LDIE. Methods: Retrospective examinations were carried out in Reference Clinical Cardiology Centre in Lublin, Poland. The study group comprised 767 patients who between 2009 and 2014 underwent transvenous lead extraction (TLE) for infective and non-infective reasons. Results: The study group comprised 382 patients with infective complications and 385 without infection. CIEDI group included 30.1% LDIE patients, 38.48% pocket infection patients (PI) and 31.41% mixed LDIE and PI patients. Fever was most frequently reported in LDIE patients. Significantly more LDIE patients were found to suffer from concomitant infections. LDIE group comprised significantly more patients with hs-CRP>50 mg/dL. Analysis of microbiological data showed that the most common cause of the infective complications were Staphylococcus epidermis and Staphylococcus aureus. Echocardiography examination revealed the presence of vegetation in 78.26% of LDIE patients in TEE and in 63.48% in TTE. Conclusions: Fever and concomitant infections predominated in the clinical picture of LDIE. Hs-CRP value proved to be essential for diagnostic procedures. TEE examination proved to be more effective in revealing vegetation than TTE. The most common cause of infective complications was S. epidermidis and S. aureus which points out to the endogenic source of infections.

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“…One of the major limitations of a pacemaker is pocket infection caused by the implanted device and the limited battery lifespan of the pulse generator . Serious infections can lead to lethal complications such as urosepsis, wound dehiscence, and erosion at the pocket site.…”

Section: Soft Bioelectronics–assisted Therapymentioning

confidence: 99%

Wearable and Implantable Devices for Cardiovascular Healthcare: from Monitoring to Therapy Based on Flexible and Stretchable Electronics

Hong

Jeong

Cho

et al. 2019

Adv Funct Materials

428

271

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Cardiovascular disease is the leading cause of death and has dramatically increased in recent years. Continuous cardiac monitoring is particularly important for early diagnosis and prevention, and flexible and stretchable electronic devices have emerged as effective tools for this purpose. Their thin, soft, and deformable features allow intimate and long-term integration with biotissues, which enables continuous, high-fidelity, and sometimes large-area cardiac monitoring on the skin and/or heart surface. In addition to monitoring, intimate contact is also crucial for high-precision therapies. Combined with tissue engineering, soft bioelectronics have also demonstrated the capability to repair damaged cardiac tissues. This review highlights the recent advances in wearable and implantable devices based on flexible and stretchable electronics for cardiovascular monitoring and therapy. First, wearable/implantable soft bioelectronics for cardiovascular monitoring (e.g., the electrocardiogram, blood pressure, and oxygen saturation level) are reviewed. Then, advances in cardiovascular therapy based on soft bioelectronics (e.g., mesh pacing, ablation, robotic sleeves, and electronic stents) are discussed. Finally, device-assisted tissue engineering therapy (e.g., functional electronic scaffolds and in vitro cardiac platforms) is discussed.

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Differences of Mortality Rates between Pocket and Nonpocket Cardiovascular Implantable Electronic Device Infections

Cited by 27 publications

References 24 publications

Thrombocytopenia and end stage renal disease are key predictors of survival in patients with cardiac implantable electronic device infections

Thrombocytopenia and end stage renal disease are key predictors of survival in patients with cardiac implantable electronic device infections

Etiology, Clinical Manifestations and Microbiological Profile of Cardiac Device Infections

Wearable and Implantable Devices for Cardiovascular Healthcare: from Monitoring to Therapy Based on Flexible and Stretchable Electronics

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