Differences of Various Region-of-Interest Methods for Measuring Dopamine Transporter Availability UsingTc99m-TRODAT-1 SPECT

Abstract

This study was to investigate whether various region-of-interest (ROI) methods for measuring dopamine transporter (DAT) availabilities by single photon emission computed tomography (SPECT) are statistically different, whether results of medical research are thereby influenced, and causes of these differences. Eighty-four healthy adults with 99mTc-TRODAT-1 SPECT and magnetic resonance imaging (MRI) scans were included. Six major analysis approaches were compared: (1) ROI drawn on the coregistered MRI; (2) ROIs drawn on the SPECT images; (3) standard ROI templates; (4) threshold-ROIs; (5) atlas-based mappings with coregistered MRI; and (6) atlas-based mappings with SPECT images. Using the atlas-based approaches we assessed the influence of striatum ROIs by slice-wise and voxel-wise comparisons. In (5) and (6), three partial-volume correction (PVC) methods were also explored. The results showed that DAT availabilities obtained from different methods were closely related but quite different and leaded to significant differences in determining the declines of DAT availability per decade (range: 5.95–11.99%). Use of 3D whole-striatum or more transverse slices could avoid biases in measuring the striatal DAT declines per decade. Atlas-based methods with PVC may be the preferable methods for medical research.

Impact of a combination of quantitative indices representing uptake intensity, shape, and asymmetry in DAT SPECT using machine learning: comparison of different volume of interest settings

“…Although Shimizu et al have compared the usefulness of the two types of VOI settings in distinguishing dementia with Lewy bodies (DLB) from Alzheimer’s disease (AD) [12]; they examined only the SBR index and did not examine other indices. Tossici-Bolt et al and Yin et al have demonstrated the influence of VOI settings on the SBR index itself [13, 14]. However, their studies did not assess the diagnostic accuracy for PS.…”

The Association Between Parkinson’s Disease and Attention-Deficit Hyperactivity Disorder

“…Only one person (K.Y., Yeh) analyzed data to avoid bias. For 99mTc-TRODAT-1/SPECT, the intensities on the striatum were measured by regions of interest (ROI) 61 , drawn on that region which comprised three contiguous slices with the highest activity, based on corresponding computed tomography (CT) images. The CT images were acquired on a 1.5 T instrument (Picker, Cleveland, OH, USA) and resliced, resized, and coregistered to all corresponding SPECT images in planes parallel to the canthomeatal line.…”

Avaliação quantitativa e qualitativa da densidade de transportadores pré-sinápticos de Dopamina em pacientes saudáveis e em portadores de Doença de Parkinson: um estudo de SPECT com [99mTc]-TRODAT-1

“…(ASENBAUM et al, 1997;DAVID MOZLEY et al, 2000; HUANG et al, [s.d. ]; HWANG et al, 2004;KAASINEN et al, 2015;OTTAVIANI et al, 2006;YIN et al, 2014). A composição final é feita somando-se as imagens.…”