Different approaches and role of dinoprostone vaginal insert in induction of labour

Abstract

Prostaglandin E2 (PGE2) plays a crucial role in cervical ripening and initiating parturition. The Dinoprostone vaginal insert, containing 10 mg of Dinoprostone within a polymeric hydrogel matrix, ensures controlled and consistent release. In women with intact membranes, the release rate averages 0.3 mg per hour, while in those with premature rupture of membranes, variability may occur. Compared to Dinoprostone gel, the insert significantly increases the likelihood of achieving vaginal delivery within 24 hours, with shorter hospital stays and reduced postpartum haemorrhage. The scientific and clinical discussion held in a forum, comprising experienced gynaecologists of India, discussed their clinical experience, shared their views and opinions on the Dinoprostone vaginal insert’s role in labour induction, reaching consensus through evidence-based statements.