Different Associations of Systolic Blood Pressure and Body Mass Index With Cardiac Structure and Function in Young Children

Wu, Yujian; Li, Zhuoyan; Du, Bowen; Ye, Yujiao; Wang, Hualin; Niu, Yiwei; Sun, Chen; Wu, Yu; Jin, Hong; Zhang, Xi; Wang, Jian; Kim, Sun

doi:10.1161/hypertensionaha.122.19396

Cited by 3 publications

(3 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Generally, patients with primary HT usually have high BMI and a higher BMI is positively associated with a high systolic BP [ 16 ]. Such patients with a decrease in BMI may have a good control of BP.…”

Section: Discussionmentioning

confidence: 99%

Control of blood pressure in hypertensive children and adolescents assessed by ambulatory blood pressure monitoring

Vigraijaroenying,

Pirojsakul,

Katanyuwong

et al. 2024

BMC Pediatr

View full text Add to dashboard Cite

Background There have been few studies evaluating the control of hypertension (HT) in children. This study aimed to assess the control of HT using ambulatory blood pressure monitoring (ABPM) and to compare the parameters between the uncontrolled HT and controlled HT groups. Methods Hypertensive patients aged ≥ 5 years who underwent ABPM to assess the control of HT were enrolled. Demographics, office blood pressure (BP), ABPM, and echocardiographic data were collected. Controlled HT was defined using a BP goal recommended by the 2016 European Society of Hypertension guidelines. Results There were 108 patients (64.8% males) with a mean age of 14.3 years and 51.9% had primary HT. Controlled HT was detected in 41.1% and 33.3% by office BP and ABPM, respectively. Based on ABPM, there was a greater prevalence of controlled HT in the primary HT than the secondary HT group (44.6% vs. 21.2%, P = 0.01). In the primary HT group, BMI z-score at the last follow-up had a significant decrease in the controlled HT than the uncontrolled HT group (-0.39 vs. 0.01, P = 0.032). Primary HT was negatively associated with uncontrolled HT by ABPM. In addition, ABPM showed greater sensitivity (77.8% vs. 55.8%) and negative predictive value (80.9% vs. 70.8%) to predict LVH than those of office BP measurement. Conclusion Only one-third of patients achieved the BP goal by ABPM and most were in the primary HT group. Weight reduction is an important measure of BP control in patients with primary HT to attenuate the risk of LVH.

show abstract

Section: Discussionmentioning

confidence: 99%

Control of blood pressure in hypertensive children and adolescents assessed by ambulatory blood pressure monitoring

Vigraijaroenying,

Pirojsakul,

Katanyuwong

et al. 2024

BMC Pediatr

View full text Add to dashboard Cite

show abstract

“…GA had a negative association with BP, which means that preterm babies might have a higher BP in the future. It has been proposed that LV hypertrophy is caused by high SBP [ 59 ]. According to current studies, preterm children have smaller heart sizes and masses than term babies.…”

Section: Discussionmentioning

confidence: 99%

The association of gestational age and birthweight with blood pressure, cardiac structure, and function in 4 years old: a prospective birth cohort study

Wang

et al. 2023

BMC Med

Self Cite

View full text Add to dashboard Cite

Background Current evidence relating birthweight and gestational age to cardiovascular risk is conflicting. Whether these factors have independent or interactive impacts on cardiovascular parameters during early childhood remains unclear. The goal of this study was to explore whether there were any independent and interactive effects of gestational age and birthweight on blood pressure, left ventricle (LV) structure, and function in 4 years old. Methods This study included 1194 children in the Shanghai Birth Cohort from 2013 to 2016. Information about the mothers and children was recorded at time of birth using a questionnaire. Follow-up measurements, including anthropometric, blood pressure, and echocardiography, were taken between 2018 and 2021, when the children were 4 years old. Multiple linear or logistic regressions and restricted cubic spline were used to explore the association of birthweight and gestational age with cardiovascular measurements. Results Gestational age had a significant negative correlation with both systolic blood pressure [β = − 0.41, 95% CI: (− 0.76, − 0.07)] and mean arterial pressure [β = − 0.36, 95%CI: (− 0.66, − 0.07)]. The risk of prehypertension decreased with increased gestational age [OR = 0.54, 95% CI: (0.32, 0.93)]. The relationship between birthweight with blood pressure was U-shape (P for non-linear < 0.001). The wall thickness, volume, mass, and cardiac output of LV increased with birthweight, though the ejection fraction [β = − 1.02, 95% CI: (− 1.76, − 0.27)] and shorten fraction [β = 0.72, 95% CI: (− 1.31, − 0.14)] decreased with birthweight. The risk of LV hypertrophy was not associated with birthweight [OR = 1.59, 95% CI: (0.68, 3.73)]. Conclusions In this study, we found different associations of birthweight and gestational age with cardiovascular measurements in the offspring at 4 years old. Gestational age influenced blood pressure independent of birthweight. Heart size and function at 4 years old was influenced mostly by birthweight and not by gestational age.

show abstract

“…To accurately evaluate changes in cardiac function in diabetic cardiomyopathy, this study excluded patients with hypertension, coronary heart disease, and valvular disease. Patients with T2DM were matched with healthy individuals based on BMI, gender, age, and smoking status to minimize the impact of these factors on cardiac function ( 19 , 20 ). The findings underscored impaired diastolic function in patients with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Association between glycosylated hemoglobin levels, diabetes duration, and left ventricular diastolic dysfunction in patients with type 2 diabetes and preserved ejection fraction: a cross-sectional study

Li,

Zhao,

Yuan

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundWe aimed to explore the intricate interplay between glycated hemoglobin (HbA1C) levels, disease duration, and left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus (T2DM) characterized by preserved ejection fraction.MethodsA cross-sectional study was conducted at the Second Affiliated Hospital of Hebei Medical University from January 2022 to December 2022. A total of 114 inpatients from the Department of Endocrinology were randomly selected based on the inclusion and exclusion criteria. Patients with T2DM were stratified into three subgroups, each comprising 38 patients, based on disease duration and HbA1C levels. A sub-analysis was conducted to explore variations among these three distinct groups. A control group comprised 38 age, gender, body mass index (BMI), and smoking habit-matched healthy volunteers form the Physical Examination Center of the same hospital. General demographic information, biochemical results, and echocardiographic data were collected, and correlation and linear regression analyses were performed.ResultsDiabetic patients exhibited lower E/A values (0.85 (0.72, 1.17) vs. 1.20 (0.97, 1.30)) and elevated E/e’ values (9.50 (8.75, 11.00) vs. 9.00 (7.67, 9.85)) compared to their normal controls. In the subgroup analysis, patients with a disease duration exceeding 2 years displayed reduced E/A values (0.85 (0.75, 1.10) vs. 1.10 (0.80, 1.30)) and elevated E/e’ values (9.80 (9.20, 10.80) vs. 8.95 (7.77, 9.50)) in comparison to those with a disease duration of ≤2 years, p<0.05. Among patients with a disease duration surpassing 2 years, those with higher HbA1C levels exhibited lower E/A values (0.80 (0.70, 0.90) vs. (0.85 (0.75, 1.10)) and higher E/e’ values (11.00 (9.87, 12.15) vs. 9.80 (9.20, 10.80)) in contrast to patients with low HbA1C levels, p<0.05. Multiple linear regression analysis identified HbA1C (β=0.294, p<0.001) and disease duration (β=0.319, p<0.001) as independent risk factors for the E/A value in diabetes patients. Furthermore, HbA1C (β=0.178, p=0.015) and disease duration (β=0.529, p<0.001) emerged as independent risk factors for the E/e’ value in diabetic patients.ConclusionsIn individuals with T2DM exhibiting preserved ejection fraction, the presence of left ventricular diastolic dysfunction is significantly associated with HbA1C levels and the duration of diabetes.

show abstract

Different Associations of Systolic Blood Pressure and Body Mass Index With Cardiac Structure and Function in Young Children

Cited by 3 publications

References 57 publications

Control of blood pressure in hypertensive children and adolescents assessed by ambulatory blood pressure monitoring

Control of blood pressure in hypertensive children and adolescents assessed by ambulatory blood pressure monitoring

The association of gestational age and birthweight with blood pressure, cardiac structure, and function in 4 years old: a prospective birth cohort study

Association between glycosylated hemoglobin levels, diabetes duration, and left ventricular diastolic dysfunction in patients with type 2 diabetes and preserved ejection fraction: a cross-sectional study

Contact Info

Product

Resources

About