Different biases in meta-analyses of case-control and cohort studies: an example from genomics and precision medicine

Palumbo, Sarah A.; Robishaw, Janet D.; Krasnoff, Joanne B.; Hennekens, Charles H.

doi:10.1016/j.annepidem.2021.02.013

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…Studies will be grouped according to their designs, such that, case-control, cohort, cross-sectional, and longitudinal studies will be analysed and reported separately [ 31 ]. Furthermore, due to anticipated sociodemographic changes over time, both aggregate (1946 to 2023) and separate analyses (20 years intervals; 1946 to 1966, 1967 to 1987, 1988 to 2008, 2009 to 2023) will be conducted for studies based on time-lagged data to determine the direction of associations over time.…”

Section: Methodsmentioning

confidence: 99%

Association between sociodemographic factors and mobility limitation among older adults: a systematic review and meta-analysis protocol

et al. 2023

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Background Mobility is an independent predictor of physical functionality, healthy ageing, and quality of life. Various literatures have associated mobility limitation in older adulthood with demographic and socioeconomic factors. Hence, we propose a systematic review and meta-analysis to synthesise the association between sociodemographic factors and mobility limitations in older adults. Methods and analyses This protocol was written according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines. We will perform a comprehensive search of all observational studies that assessed the relationship between age, gender, race, place, education, income, occupation, social status, and walking distance, time, or speed. Electronic databases (MEDLINE, Web of Science, EMBASE, CINAHL, AgeLine, and SPORTDiscus) will be searched from inception to 28 February 2023. We will supplement the database search by manually searching the reference lists of all identified and relevant full-text articles. Two independent reviewers will be responsible for screening articles, data extraction, and assessment of bias. We will appraise the study quality and risk of bias using the Prediction Model Risk of Bias Assessment Tool (PROBAST). A meta-analysis will be considered if data from the selected studies are homogeneous, otherwise, a narrative synthesis of the extracted data will be presented. Discussion Mobility limitation leads to frequent falls, dependency, morbidity, and death among older adults. This review is necessary, to identify and prioritise important sociodemographic factors during older adults’ clinical assessment and policy development. It is the first phase of a multi-methods study seeking to develop a prognostic mobility trajectory for community-dwelling older adults. Systematic review registration PROSPERO CRD42022298570

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Section: Methodsmentioning

confidence: 99%

Association between sociodemographic factors and mobility limitation among older adults: a systematic review and meta-analysis protocol

et al. 2023

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“…Meta-analysis is based on predetermined mathematical criteria for the statistical analysis of high-quality research [ 47 ], and it has been widely used in many fields such as medicine [ 48 ], environmental science [ 49 ], and organizational behavior [ 9 ]. The main reasons for the authors of this study to carry out research on the mechanism of the role of government green development behavior based on meta-analysis are as follows.…”

Section: Methods and Datamentioning

confidence: 99%

What Is the Mechanism of Government Green Development Behavior Considering Multi-Agent Interaction? A Meta-Analysis

Dai

Zhu

et al. 2022

IJERPH

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Worsening environmental problems have created more and more challenges for green development, and the government is often seen as an important guide in turning this situation around. A government generally enacts green development through green development behavior, but previous research has not revealed the mechanism of this behavior. In addition, the multi-agent interaction between the government and green development behavior also needs to be explored. Based on an integrated theoretical model, the authors of this study adopted a meta-analysis method to analyze 18 high-quality published pieces from 6 mainstream databases and described the mechanism of government green development behavior in exploring and thinking about multi-agent interactions. In addition, the authors of this study explored differences in the roles of central and local government green development behaviors and the moderating role of regional heterogeneity. The research results showed that: (1) Enterprise economic behavior, enterprise environmental behavior, enterprise social behavior, and public participation are all significantly positively affected by government green development behavior; (2) local government green development actions have stronger effects than central government actions; (3) regional heterogeneity moderates the effect of government green development behavior. Furthermore, the authors of this study propose relevant countermeasures and suggestions from the government’s point of view. This research provides a theoretical and practical reference for governments to better improve their environmental systems and environmental supervision.

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MicroRNA expression alteration in chronic thromboembolic pulmonary hypertension: A systematic review

Sulastomo,

Dinarti,

Hariawan

et al. 2024

Pulm. circ.

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Chronic thromboembolic pulmonary hypertension (CTEPH) is marked by persistent blood clots in pulmonary arteries, leading to significant morbidity and mortality. Emerging evidence highlights the role of microRNAs (miRNAs) in pulmonary hypertension, though findings on miRNA expression in CTEPH remain limited and inconsistent. This systematic review evaluates miRNA expression changes in CTEPH and their direction. Following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines, we registered our protocol in International Prospective Register of Systematic Reviews (CRD42024524469). We included studies on miRNA expression in CTEPH with comparative or analytical designs, excluding nonhuman studies, interventions, non‐English texts, conference abstracts, and editorials. Databases searched included PubMed, EMBASE, Scopus, CENTRAL, and ProQuest. The Quality Assessment of Diagnostic Accuracy Studies‐2 tool assessed bias risk, and results were synthesized narratively. Of 313 unique studies, 39 full texts were reviewed, and 9 met inclusion criteria, totaling 235 participants. Blood samples were analysed using quantitative real time polymerase chain reaction. Seven miRNAs (miR‐665, miR‐3202, miR‐382, miR‐127, miR‐664, miR‐376c, miR‐30) were uniformly upregulated, while nine (miR‐20a‐5p13, miR‐17‐5p, miR‐93‐5p, miR‐22, let‐7b, miR‐106b‐5p, miR‐3148, miR‐320‐a, miR‐320b) were downregulated in CTEPH patients. Two upregulated miRNAs (miR‐127 and miR‐30a) were consistently associated with previous evidence in the mechanism inducing the development of CTEPH, and five downregulated miRNAs (miR‐20‐a, miR‐17‐5p, miR‐93‐5p, let‐7b, miR‐106b‐5p) were associated with a protective effect against CTEPH. We also identified gaps in the literature where the evidence for five upregulated miRNAs (miR‐665, miR‐3202, miR‐382, miR‐664 and miR‐376c) and four downregulated miRNAs (miR‐22, miR‐3148, miR‐320‐a, and miR‐320b) in CTEPH is conflicting. Our findings offer insights into the role of miRNAs in CTEPH and underscore the need for further research to validate these miRNAs as biomarkers or therapeutic targets.

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Different biases in meta-analyses of case-control and cohort studies: an example from genomics and precision medicine

Cited by 5 publications

References 15 publications

Association between sociodemographic factors and mobility limitation among older adults: a systematic review and meta-analysis protocol

Association between sociodemographic factors and mobility limitation among older adults: a systematic review and meta-analysis protocol

What Is the Mechanism of Government Green Development Behavior Considering Multi-Agent Interaction? A Meta-Analysis

MicroRNA expression alteration in chronic thromboembolic pulmonary hypertension: A systematic review

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