Different clinical course of pallidal deep brain stimulation for phasic- and tonic-type cervical dystonia

Chung, Moonyoung; Huh, Ryoong

doi:10.1007/s00701-015-2646-7

Cited by 33 publications

(22 citation statements)

References 54 publications

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“…18 Both neuroimaging and electrophysiological studies have revealed structural and functional network changes in dystonic patients that have resulted in the current opinion that dystonia is a circuit disorder. 42 Although these findings support the notion that suppression of theta activity may be one potential mechanism of pallidal DBS in dystonia, long-term recordings after chronic DBS will have to prove the stability of theta oscillations as recently reported for beta activity in PD. 26 Interestingly, pallidal theta activity was found to be negatively correlated with physiological motor cortical beta and cerebellar alpha band oscillations.…”

Section: Role Of Pallidal Theta Activity In the Pathophysiology Of Dysupporting

confidence: 67%

A localized pallidal physiomarker in cervical dystonia

Neumann

Horn

Ewert

et al. 2017

Annals of Neurology

140

120

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Our findings suggest that theta oscillations in the internal pallidum are robustly associated with dystonic symptoms in cervical dystonia and may be a useful biomarker for adaptive closed-loop stimulation. Furthermore, theta oscillatory activity may have a predictive value for the clinical benefit after chronic DBS that could be used to improve intraoperative neurophysiological target mapping during electrode implantation. Ann Neurol 2017;82:912-924.

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Section: Role Of Pallidal Theta Activity In the Pathophysiology Of Dysupporting

confidence: 67%

A localized pallidal physiomarker in cervical dystonia

Neumann

Horn

Ewert

et al. 2017

Annals of Neurology

140

120

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“…5 With conventional cDBS, the clinical improvement of phasic and tonic components differs in time; phasic components improve faster (sometimes even immediately) following the application of DBS, whereas improvement in tonic components can take weeks to months. 11 In contrast, when discontinuing stimulation, phasic components can recur rapidly, while tonic components recur in a more gradual manner. 19 This temporal dissociation leads to the hypothesis that different pathophysiological mechanisms are involved.…”

Section: Phasic and Tonic Components Of Dystoniamentioning

confidence: 99%

Toward adaptive deep brain stimulation for dystonia

Piña-Fuentes

Beudel

Little

et al. 2018

Neurosurgical Focus

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The presence of abnormal neural oscillations within the cortico-basal ganglia-thalamo-cortical (CBGTC) network has emerged as one of the current principal theories to explain the pathophysiology of movement disorders. In theory, these oscillations can be used as biomarkers and thereby serve as a feedback signal to control the delivery of deep brain stimulation (DBS). This new form of DBS, dependent on different characteristics of pathological oscillations, is called adaptive DBS (aDBS), and it has already been applied in patients with Parkinson’s disease. In this review, the authors summarize the scientific research to date on pathological oscillations in dystonia and address potential biomarkers that might be used as a feedback signal for controlling aDBS in patients with dystonia.

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“…Furthermore, the mechanism of action of DBS still remains mostly unclear. Previous studies showed immediate effects on oscillatory basal ganglia network activity related to suppression of phasic movements that are also the first to respond to DBS in dystonia . Abnormal posturing usually improves over longer time periods, which is possibly related to functional reorganization of the motor cortex—basal ganglia circuits and plastic changes .…”

Section: Introductionmentioning

confidence: 98%