Different Clinical Features of Celiac Disease in Children, Adolescents, and Adults; a Cross-sectional Study

Abstract

BACKGROUND Celiac disease is a common disorder but there are few studies comparing the clinical features of the disease in adults, adolescents and children. METHODS Demographic and clinical characteristics of all patients with celiac disease referred to the Celiac Clinic were evaluated and compared in different age groups. RESULTS Of 3416 participants, 473 patients were included. 302 (63.8%) were women and 171 (36.2%) were men. Overall, 325 (68.7%) and 411 (86.9%) patients had gastrointestinal (GI) and non-GI manifestations, respectively. The most common symptom in adults was psychiatric problems (66.5%), while abdominal discomfort was the most common symptom in adolescents (45.2%) and children (53.8%). According to age groups, GI manifestations were seen in 79 (66.4%), 119 (59.8%), and 127 (81.9%) children, adolescents, and adults, respectively. Adults had significantly more GI manifestations than the other groups (PR 1.167; 95% CI: 1.094- 1.244; p < 0.001). Non-GI manifestations were seen in 90 (75.6%), 174 (87.4%), and 147 (94.8%) children, adolescents, and adults, respectively. Adults had significantly more non-GI manifestations than the other groups (PR 1.112; 95% CI: 1.060-1.168; p < 0.001). CONCLUSION Our study showed that there were significant differences in the clinical features of celiac disease between the different age groups. Considering these results may help plan for future studies.

Liver abnormalities in celiac disease and response to gluten free diet: A systematic review and meta‐analysis

“…A detailed flow of the studies included in the meta‐analysis is shown in figure 1 (PRISMA figure). The details of the included studies are shown in Table 1 17–67 . Excluded studies with reason of exclusion are shown in Table S2.…”

Relationship Between Celiac Disease and Dental Caries in Children and Adolescents: A Systematic Review and Meta-Analysis

“…Abdominal discomfort, including abdominal pain, bloating, and distention, were the most common symptoms reported by celiac disease patients in the study [4]. However, other manifestations such as chronic diarrhea, weight loss, iron deficiency with or without anemia, short stature, chronic fatigue, reduced bone mineral density, dermatitis herpetiformis, and gluten ataxia may also be observed, in addition to the asymptomatic form of the disease [5].…”