Different contribution of EBV and CMV infections in very long-term carriers to age-related alterations of CD8+ T cells

Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily

“…However, the range of CMV values, both for percentage of CD8 CMV-specific cells and absolute numbers per µl of blood, is much greater in the old than young, with some elderly having large accumulations of CMV-specific cells, as seen in another Italian study (Vescovini et al, 2004) .…”

Aging of the Immune System as a Prognostic Factor for Human Longevity

“…Inflamm-aging is the end result of such a process characterized by activation of macrophages and expansion of specific clones (megaclones) of T lymphocytes directed toward antigens of common viruses such as cytomegalovirus (CMV) or Epstein-Barr virus (EBV) (FIGURE 1; Refs. 31,49,81,85,116). All these phenomena have a strong genetic component, as shown by studies in old people and centenarians, which collectively established that the frequency of several variants (polymorphisms) of important genes involved in immune responses and inflammation are present at a different frequency in long-lived people compared with young subjects (FIGURE 1; Refs.…”

“…All these phenomena have a strong genetic component, as shown by studies in old people and centenarians, which collectively established that the frequency of several variants (polymorphisms) of important genes involved in immune responses and inflammation are present at a different frequency in long-lived people compared with young subjects (FIGURE 1; Refs. 23,41,96,97,116). Within this scenario, the age-related changes in body composition (loss of muscle/bone mass and increase of fat mass) (84), insulin growth factor 1/insulin pathway (36), as well as inflammatory phenomena occurring in the central nervous system are also emerging as critical influences on the development of frailty and major age-related diseases (59,121,124).…”

Human cytomegalovirus infection of human adipose-derived stromal/stem cells restricts differentiation along the adipogenic lineage

“…18 Long thought of as nonproblematic, HCMV latency is now being investigated for a possible role in chronic conditions including metabolic syndrome, cardiovascular disease, diabetes, cognitive impairment, and immunosenescence. [18][19][20][21] Recent studies show that HCMV infects progenitor cells of various types resulting in alterations in their phenotype and function. [22][23][24] The goal of this study was to determine if ASCs are susceptible and permissive for productive infection by HCMV, and if so, the consequences in terms of differentiation potential and anti-inflammatory properties.…”