2005
DOI: 10.1002/dmrr.595
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Different contributions of insulin resistance and beta‐cell dysfunction in overweight Israeli Arabs with IFG and IGT

Abstract: Background Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) are both intermediate stages that exist between normal glucose tolerance and overt type 2 diabetes. Epidemiological studies demonstrated that the two categories define distinct populations. In this study, we examined the contributions of insulin resistance and beta-cell dysfunction to both states in overweight subjects of Arab origin.

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Cited by 38 publications
(24 citation statements)
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“…As HOMA-IR and HOMA-B were only surrogate measures of insulin sensitivity and insulin secretion, further investigations are warranted. IR and decreased insulin secretion are the major factors contributing to the deterioration of glucose metabolism [14,15]. Elderly individuals are apparently able to maintain normal glucose tolerance by secreting more insulin to overcome the IR [16].…”
Section: Discussionmentioning
confidence: 99%
“…As HOMA-IR and HOMA-B were only surrogate measures of insulin sensitivity and insulin secretion, further investigations are warranted. IR and decreased insulin secretion are the major factors contributing to the deterioration of glucose metabolism [14,15]. Elderly individuals are apparently able to maintain normal glucose tolerance by secreting more insulin to overcome the IR [16].…”
Section: Discussionmentioning
confidence: 99%
“…Our approach to study insulin sensitivity using the FSIGT-derived S i at 24 h post-LPS is limited in that we cannot differentiate various contributions of changes in hepatic and peripheral insulin sensitivity versus the total body change and cannot define the kinetics of the development and resolution of IR. However, we utilized the FSIGT S i as a sensitive measure of peripheral IR and combined this with the HOMA-IR that correlates best with measures of hepatic insulin sensitivity (24). Furthermore, FSIGT enabled examination of whether pancreatic ␤-cell function changes during inflammation-induced IR, while the hyperinsulinemic-eugylemic clamp does not.…”
Section: Insulinmentioning
confidence: 99%
“…8,[10][11][12][13][14] In contrast, insulin sensitivity has been shown to be lower in both IFG and IGT subjects when estimated based on an oral glucose tolerance test (OGTT) or homeostasis model assessment for insulin resistance (HOMA IR ). [15][16][17] The underlying mechanisms for impairments in insulin sensitivity in subjects with IGM are not yet fully understood. Skeletal muscle and adipose tissue are important organs in regulating fatty acid (FA) metabolism.…”
Section: Introductionmentioning
confidence: 99%