Different corticostriatal integration in spiny projection neurons from direct and indirect pathways

Flores-Barrera, Edén; Vizcarra-Chacón, Bianca J.; Tapia, Dagoberto; Bargas, José; Galarraga, Elvira

doi:10.3389/fnsys.2010.00015

Cited by 50 publications

(119 citation statements)

References 54 publications

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“…Regardless of cortical activity, TTX injection profoundly modified the activity of striatal neuronal subtypes. In accordance with the literature on chronically denervated animals, we found a mean overall increase of the firing rate of putative striatal projection neurons (Flores-Barrera et al, 2010;Hernandez-Lopez et al, 2000;Mallet et al, 2006;Shen et al, 2007;Surmeier et al, 2010;West and Grace, 2002). Striatal cholinergic interneurons undergo an increase in excitability in chronically dopaminedepleted animals (Salin et al, 2009).…”

Section: Discussionsupporting

confidence: 91%

Acute nigro-striatal blockade alters cortico-striatal encoding: An in vivo electrophysiological study

Prosperetti

Giovanni

Galati

2013

Experimental Neurology

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Spreading of slow cortical rhythms into the basal ganglia (BG) is a relatively well-demonstrated phenomenon in the Parkinsonian state, both in humans and animals. Accordingly, striatal dopamine (DA) depletion, either acute or chronic, drives cortical-globus pallidus (GP) and cortical-substantia nigra pars reticulata (SNr) slow wave coherences in urethane-anesthetized rats. This paper investigates the striatal dynamics following acute DA depletion by tetrodotoxin (TTX) injection in the medial forebrain bundle (MFB) with respect to the transmission of slow cortical rhythms throughout the BG in more detail. The acute DA depletion offers the advantage of detecting electrophysiological changes irrespectively of chronically developing compensatory mechanisms. We observed that the acute blockade of the dopaminergic nigro-striatal pathway reshapes the firing rate and pattern of the different striatal neuron subtypes according to cortical activity, possibly reflecting a remodeled intrastriatal network. The observed alterations differ amongst striatal neuronal subtypes with the striatal medium spiny neurons and fast-spiking neurons being the most affected, while the tonically active neurons seem to be less affected. These acute changes might contribute to the diffusion of cortical activity to BG and the pathophysiology of Parkinson's disease (PD).

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Section: Discussionsupporting

confidence: 91%

Acute nigro-striatal blockade alters cortico-striatal encoding: An in vivo electrophysiological study

Prosperetti

Giovanni

Galati

2013

Experimental Neurology

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“…Both actions occurring simultaneously promote the selection of highly probable cycles of reverberating activity that are relatively fixed. The increase in lateral inhibition and network synchrony is consistent with the enhancement of postsynaptic excitability and depolarizing inhibition among active neurons (Flores-Barrera et al, 2010. This circuit characteristic may underlie action selection (Grillner et al, 2005b).…”

Section: Discussionmentioning

confidence: 77%

Dopaminergic Modulation of the Striatal Microcircuit: Receptor-Specific Configuration of Cell Assemblies

Carrillo-Reid

Hernández‐López²,

Tapia³

et al. 2011

J. Neurosci.

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Selection and inhibition of motor behaviors are related to the coordinated activity and compositional capabilities of striatal cell assemblies. Striatal network activity represents a main step in basal ganglia processing. The dopaminergic system differentially regulates distinct populations of striatal medium spiny neurons (MSNs) through the activation of D 1 -or D 2 -type receptors. Although postsynaptic and presynaptic actions of these receptors are clearly different in MSNs during cell-focused studies, their activation during network activity has shown inconsistent responses. Therefore, using electrophysiological techniques, functional multicell calcium imaging, and neuronal population analysis in rat corticostriatal slices, we describe the effect of selective dopaminergic receptor activation in the striatal network by observing cell assembly configurations. At the microcircuit level, during striatal network activity, the selective activation of either D 1 -or D 2 -type receptors is reflected as overall increases in neuronal synchronization. However, graph theory techniques applied to the transitions between network states revealed receptor-specific configurations of striatal cell assemblies: D 1 receptor activation generated closed trajectories with high recurrence and few alternate routes favoring the selection of specific sequences, whereas D 2 receptor activation created trajectories with low recurrence and more alternate pathways while promoting diverse transitions among neuronal pools. At the single-cell level, the activation of dopaminergic receptors enhanced the negative-slope conductance region (NSCR) in D 1 -type-responsive cells, whereas in neurons expressing D 2 -type receptors, the NSCR was decreased. Consequently, receptor-specific network dynamics most probably result from the interplay of postsynaptic and presynaptic dopaminergic actions.

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“…It could have been that MSNs belonging to different response clusters represent different types of cells. In our study design, which involved extracellular recordings from behaving monkeys, we were not able to tag or characterize single cells (Belujon et al, 2010;Flores-Barrera et al, 2010). However, we could examine the spiking parameters of the cells, which are often used to classify cells recorded in the same location into different types (for example, in our study, MSNs vs TANs).…”

Section: Msns Response Profile Does Not Reflect the Neurons' Intrinsimentioning

confidence: 99%

Temporal Convergence of Dynamic Cell Assemblies in the Striato-Pallidal Network

Adler¹,

Katabi²,

Finkes³

et al. 2012

J. Neurosci.

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The basal ganglia (BG) have been hypothesized to implement a reinforcement learning algorithm. However, it is not clear how information is processed along this network, thus enabling it to perform its functional role. Here we present three different encoding schemes of visual cues associated with rewarding, neutral, and aversive outcomes by BG neuronal populations.We studied the response profile and dynamical behavior of two populations of projection neurons [striatal medium spiny neurons (MSNs), and neurons in the external segment of the globus pallidus (GPe)], and one neuromodulator group [striatal tonically active neurons (TANs)] from behaving monkeys. MSNs and GPe neurons displayed sustained average activity to cue presentation. The population average response of MSNs was composed of three distinct response groups that were temporally differentiated and fired in serial episodes along the trial. In the GPe, the average sustained response was composed of two response groups that were primarily differentiated by their immediate change in firing rate direction. However, unlike MSNs, neurons in both GPe response groups displayed prolonged and temporally overlapping persistent activity. The putamen TANs stereotyped response was characterized by a single transient response group. Finally, the MSN and GPe response groups reorganized at the outcome epoch, as different task events were reflected in different response groups.Our results strengthen the functional separation between BG neuromodulators and main axis neurons. Furthermore, they reveal dynamically changing cell assemblies in the striatal network of behaving primates. Finally, they support the functional convergence of the MSN response groups onto GPe cells.

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Different corticostriatal integration in spiny projection neurons from direct and indirect pathways

Cited by 50 publications

References 54 publications

Acute nigro-striatal blockade alters cortico-striatal encoding: An in vivo electrophysiological study

Acute nigro-striatal blockade alters cortico-striatal encoding: An in vivo electrophysiological study

Dopaminergic Modulation of the Striatal Microcircuit: Receptor-Specific Configuration of Cell Assemblies

Temporal Convergence of Dynamic Cell Assemblies in the Striato-Pallidal Network

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