Different Curcumin-Loaded Delivery Systems for Wound Healing Applications: A Comprehensive Review

Abstract

Curcumin or turmeric is the active constituent of Curcuma longa L. It has marvelous medicinal applications in many diseases. When the skin integrity is compromised due to either acute or chronic wounds, the body initiates several steps leading to tissue healing and skin barrier function restoration. Curcumin has very strong antibacterial and antifungal activities with powerful wound healing ability owing to its antioxidant activity. Nevertheless, its poor oral bioavailability, low water solubility and rapid metabolism limit its medical use. Tailoring suitable drug delivery systems for carrying curcumin improves its pharmaceutical and pharmacological effects. This review summarizes the most recent reported curcumin-loaded delivery systems for wound healing purposes, chiefly hydrogels, films, wafers, and sponges. In addition, curcumin nanoformulations such as nanohydrogels, nanoparticles and nanofibers are also presented, which offer better solubility, bioavailability, and sustained release to augment curcumin wound healing effects through stimulating the different healing phases by the aid of the small carrier.

Development of hybrid electrospun alginate-pulverized moringa composites

“…3 appeared as compared same as a common broad peak at 3700-3000 cm −1 can be attributed to -OH stretching vibration, low-intensity bands at about 2900 cm −1 attributed to -CH 2 groups, and at 1597 and 1409 cm −1 are attributes of asymmetric and symmetric stretching modes, of carboxylate salt groups (-COONa) in the sodium alginate. [50][51][52] In the PMO, spectra also show an exceptionally good attribute compared to the literature. The broadband focused at 3419 cm −1 can be ascribed to O-H stretching which appears mainly or connected to proteins, carbohydrates, and fatty acids, and the lignin unit structure existence ascribed to the high protein content, there is also a trait of N-H stretching of amide groups in this region.…”

Chitosan/Virgin Coconut Oil-Based Emulsions Doped with Photosensitive Curcumin Loaded Capsules: A Functional Carrier to Topical Treatment

“…Incorporating natural phytochemical extracts with dermatological activity, as curcumin (CUR) from the turmeric curcuma longa, allows a more environmentally and economically advantageous approach, as it explores natural resources with high economical potential as health-improving solutions. The natural bioactive compound CUR selection relies on its antioxidant, anti-inflammatory, tissue protective, antibacterial, and wound healing properties [ 17 , 18 , 19 ]. However, it presents some limitations in its application as a therapeutic agent due to its rapid metabolism and hydrophobic properties, with consequent limited solubility, stability, and bioavailability [ 19 ].…”

“…The natural bioactive compound CUR selection relies on its antioxidant, anti-inflammatory, tissue protective, antibacterial, and wound healing properties [ 17 , 18 , 19 ]. However, it presents some limitations in its application as a therapeutic agent due to its rapid metabolism and hydrophobic properties, with consequent limited solubility, stability, and bioavailability [ 19 ]. Therefore, the design of an approach able to deliver CUR locally to an injury site or for disease treatment applications is of increasing interest [ 17 ].…”

“…Therefore, the design of an approach able to deliver CUR locally to an injury site or for disease treatment applications is of increasing interest [ 17 ]. The resource’s incorporation into biomaterials has been a widely explored strategy going from hydrogels to electrospun fibers or nanoparticles, according to the envisioned application [ 17 , 19 , 20 , 21 , 22 , 23 ].…”

Investigating the Targeting Power to Brain Tissues of Intranasal Rasagiline Mesylate-Loaded Transferosomal In Situ Gel for Efficient Treatment of Parkinson’s Disease

“…Among these approaches is the preparation of in situ-forming gels [ 23 ], where the drug is administered in solution form and transforms into gel in response to some endogenous stimuli, such as the increase in temperature or pH, or the presence of ions [ 24 , 25 ]. Combining in situ-forming gel polymers with mucoadhesive polymers results in a greater effectiveness and higher efficiency through the prolongation of the residence time at the administration site, which in turn enhances the drug bioavailability [ 26 , 27 , 28 , 29 ]. An optimum concentrations selection of the used polymers is based on the sol-to-gel transition temperatures and gelation time [ 30 ].…”