Different depths of food restriction and high‐fat diet refeeding in mice impact host obesity and metabolic phenotypes with correlative changes in the gut microbiota
Jiaqi Xu,
Huangru Xu,
Feiyan Yang
et al.
Abstract:Overweight and obesity affect almost 2 billion adults worldwide, and food restriction (FR) is commonly used to reduce body fat. Whether refeeding (Re) after FR at different ages and to different degrees leads to overweight and its possible mechanisms are uncertain. In this study, adult and young mice were both restricted to 15% and 40% of their casual food intake, and then were fed 60% high‐fat chow (FR15%–Re, FR40%–Re), whereas the control groups(CON) consumed high‐fat or normal food throughout, respectively.… Show more
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