Different Dysregulations of the Natural Antibody Repertoire in Treated and Untreated HIV-1 Patients

Quan, Canh P.; Watanabe, Shinichiro; Pamonsinlapatham, Perayot; Bouvet, Jean‐Pierre

doi:10.1006/jaut.2001.0529

Cited by 9 publications

(5 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Autoantibodies of the IgM isotype against DNA, as well as against endogenous proteins, occur in both HIV-infected humans and in an HIV transgenic mouse model (30,32). There is also an increase in circulating cardiac-specific autoantibodies in HIVpositive individuals, supporting a role for autoimmunity in the pathogenesis of HIV-related heart muscle disease (6).…”

Section: Discussionmentioning

confidence: 99%

Selective Loss of Innate CD4⁺Vα24 Natural Killer T Cells in Human Immunodeficiency Virus Infection

Sandberg

Fast

Palacios

et al. 2002

J Virol

145

148

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Selective Loss of Innate CD4⁺Vα24 Natural Killer T Cells in Human Immunodeficiency Virus Infection

Sandberg

Fast

Palacios

et al. 2002

J Virol

145

148

View full text Add to dashboard Cite

show abstract

“…Pan et al showed that normal controls contain SLE-specific autoAbs which are normally masked [ 237 ]. In HIV, dysregulation of anti-idiotypes has been proposed for the aPL patterns seen [ 238 ]. Interestingly, SLE patients seem to be protected from HIV/AIDS because they can make an aCL which neutralizes the virus, deleted in normal subjects as autoreactive [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

Antiphospholipid antibodies: Paradigm in transition

Horstman

Bidot

et al. 2009

J Neuroinflammation

View full text Add to dashboard Cite

ObjectivesThis is a critical review of anti-phospholipid antibodies (aPL). Most prior reviews focus on the aPL syndrome (APS), a thrombotic condition often marked by neurological disturbance. We bring to attention recent evidence that aPL may be equally relevant to non-thrombotic autoimmune conditions, notably, multiple sclerosis and ITP.OrganizationAfter a brief history, the recent proliferation of aPL target antigens is reviewed. The implication is that many more exist. Theories of aPL in thrombosis are then reviewed, concluding that all have merit but that aPL may have more diverse pathological consequences than now recognized. Next, conflicting results are explained by methodological differences. The lupus anticoagulant (LA) is then discussed. LA is the best predictor of thrombosis, but why this is true is not settled. Finally, aPL in non-thrombotic disorders is reviewed.ConclusionThe current paradigm of aPL holds that they are important in thrombosis, but they may have much wider clinical significance, possibly of special interest in neurology.

show abstract

“…Quan et al also made interesting observations on shifts in the repertoire of natural antibodies in treated vs. untreated HIV patients (476). Deliberate construction of anti-idiotypes against pathogenic AutoAb has been proposed for treatment of autoimmune diseases such as ITP (477).…”

Section: More Roles Of Natural Antibodiesmentioning

confidence: 99%

Complement in neurobiology

W²,

Ahn

et al. 2011

Front Biosci

View full text Add to dashboard Cite

The complement (C) system is a vital arm of innate immunity with many roles, including control of inflammation. This article examines the (C) system with emphasis on recent developments on complement relevant to neurobiology, in particular regarding our understanding and treatment of immune-mediated diseases. We will briefly outline the C system, and provide an updated review of its many receptors and regulatory factors. This section concludes with a listing of important roles of the C system, from recruitment of neural stem/progenitor cells, to its' relation to coagulation and adaptive immunity, and its lesser-known but beneficial roles in physiology. We also review evidence for C-mediated diseases, which include multiple sclerosis and Alzheimer's disease. Therapeutic approaches for C-mediated diseases, considers emphasizing modulators of the C system including several less widely studied approaches such as heparinoids, vitamin D, and intravenous IgM. Finally, we summarize cutting-edge work on the role of C-mediated natural antibodies in autoimmunity and treatment strategies based on those findings, e.g., for remyelination and post-ischemic stroke repair. Improved understanding of the C system may hold great promise for the treatment of neurodegenerative diseases.

show abstract

Different Dysregulations of the Natural Antibody Repertoire in Treated and Untreated HIV-1 Patients

Cited by 9 publications

References 35 publications

Selective Loss of Innate CD4⁺Vα24 Natural Killer T Cells in Human Immunodeficiency Virus Infection

Selective Loss of Innate CD4⁺Vα24 Natural Killer T Cells in Human Immunodeficiency Virus Infection

Antiphospholipid antibodies: Paradigm in transition

Complement in neurobiology

Contact Info

Product

Resources

About

Different Dysregulations of the Natural Antibody Repertoire in Treated and Untreated HIV-1 Patients

Cited by 9 publications

References 35 publications

Selective Loss of Innate CD4+Vα24 Natural Killer T Cells in Human Immunodeficiency Virus Infection

Selective Loss of Innate CD4+Vα24 Natural Killer T Cells in Human Immunodeficiency Virus Infection

Antiphospholipid antibodies: Paradigm in transition

Complement in neurobiology

Contact Info

Product

Resources

About

Selective Loss of Innate CD4⁺Vα24 Natural Killer T Cells in Human Immunodeficiency Virus Infection

Selective Loss of Innate CD4⁺Vα24 Natural Killer T Cells in Human Immunodeficiency Virus Infection