Different Effect of Growth Hormone on the Triglyceride Metabolism in Visceral and Subcutaneous AdiposeTissues of Rats

Abstract

To clarify the mechanism by which visceral adipose tissue developed in growth hormone (GH) deficient patients, and was reduced by GH supplementation , the effects of GH on the triglyceride metabolism in the visceral and subcutaneous adipose tissues of the rats were compared. Visceral and subcutaneous adipose tissues were obtained from omentum and abdominal wall. [14C]deoxyglucose uptake and the triglyceride synthetic activity from [14C]oleic acid , and heparin-releasable lipoprotein lipase activity were not changed by the addition of GH (10 ng/mL) in both visceral and subcutaneous adipose tissues , but the lipolysis by GH (10 ng/mL)was much more remarkable in the visceral adipose tissue than in subcutaneous adipose tissue , whereas adrenaline-induced lipolysis occurred almost equally in both tissues. These results suggest that the preponderance of visceral adipose tissue in GH deficiency might partly be due to the lack of GH-preferential lipolysis in visceral adipose tissue.