Different effect of the nitric oxide synthase inhibition between the cortical and trabecular bone of osteoporotic female rats submitted or no the physical activity

Ocarino, Natália de Melo; Boeloni, Jankerle Neves; Silva, Juneo Freitas; Goes, A.M.; Marubayashi, Umeko; Serákides, Rogéria

doi:10.1016/j.scispo.2010.04.005

Cited by 1 publication

(3 citation statements)

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“…The vertebrae for their trabecular bone content are also frequently used, but do not undergo direct mechanical stimulation in physical exercise in quadrupeds [ 29 ]. Few studies also investigated bones that are not directly submitted to mechanical stress due to exercise, such as nasal bone [ 44 ].…”

Section: Population and Bones Studiedmentioning

confidence: 99%

“…Even if bone remodeling occurs as a long-time process, short protocols (four or five weeks) could provide an increased in BMD ([ 48 , 101 ] or in trabecular parameters [ 106 ]. Thus the question is asked [ 100 ] In addition, some researchers obtained positive effects in BMD with short sessions such as 5 to 10 min a day [ 49 , 79 , 103 ], or 30 min a day [ 44 , 48 , 102 ]. However, these results were made possible either by an additional load or by an up/downhill protocol to increase the mechanical loading.…”

Section: Effects Of Physical Exercises On Bone Health Statusmentioning

confidence: 99%

“…In contrast to healthy animals, the effects of treadmill running exercise protocols in ostepenics/osteoporotic models seems to be more consensual. In most studies, the effects of exercise in osteopenic female rats counterbalanced BV/TV deterioration, but rarely increased gain in micro-architecture parameters beyond the starting values [44,[138][139][140]. Furthermore, few studies failed to show a positive effect for such parameters [79,116].…”

Section: Osteopenic Modelsmentioning

confidence: 99%

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Does Physical Exercise Always Improve Bone Quality in Rats?

Portier

Benaîtreau

Pallu

2020

Life

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For decades, the osteogenic effect from different physical activities on bone in rodents remained uncertain. This literature review presents for the first time the effects on five exercise models (treadmill running, wheel running, swimming, resistance training and vibration modes) in three different experimental rat groups (males, females, osteopenic) on bone quality. The bone parameters presented are bone mineral density, micro-architectural and mechanical properties, and osteoblast/osteocyte and osteoclast parameters. This review shows that physical activities have a positive effect (65% of the results) on bone status, but we clearly observed a difference amongst the different protocols. Even if treadmill running is the most used protocol, the resistance training constitutes the first exercise model in term of osteogenic effects (87% of the whole results obtained on this model). The less osteogenic model is the vibration mode procedure (31%). It clearly appears that the gender plays a role on the bone response to swimming and wheel running exercises. Besides, we did not observe negative results in the osteopenic population with impact training, wheel running and vibration activities. Moreover, about osteoblast/osteocyte parameters, we conclude that high impact and resistance exercise (such jumps and tower climbing) seems to increase bone formation more than running or aerobic exercise. Among the different protocols, literature has shown that the treadmill running procedure mainly induces osteogenic effects on the viability of the osteocyte lineage in both males and females or ovariectomized rats; running in voluntary wheels contributes to a negative effect on bone metabolism in older male models; whole-body vertical vibration is not an osteogenic exercise in female and ovariectomized rats; whereas swimming provides controversial results in female models. For osteoclast parameters only, running in a voluntary wheel for old males, the treadmill running program at high intensity in ovariectomized rats, and the swimming program in a specific ovariectomy condition have detrimental consequences.

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Section: Population and Bones Studiedmentioning

confidence: 99%