Different effects of bisphenol a and its halogenated derivatives on the reproduction and development of Oryzias melastigma under environmentally relevant doses

Huang, Qiansheng; Chen, Yajie; Lin, Lifeng; Liu, Yiyao; Chi, Yulang; Lin, Yi; Ye, Guozhu; Zhu, Haonan; Dong, Shuang

doi:10.1016/j.scitotenv.2017.03.263

Cited by 39 publications

(16 citation statements)

References 37 publications

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“…Our previous study showed that 50 µg L −1 BPA exposures exert an obvious physiological effect on goldfish, such as disrupted testis maturation and reduced ovarian maturation, by affecting the HPG (Hypothalamic-pituitary-gonadal) axis [19]. This concentration can also be detected in aquatic environments [7,8].…”

Section: Introductionmentioning

confidence: 98%

“…Fish are often used to evaluate the health of aquatic ecosystems, in particular, physiological and biochemical changes in fish are considered biomarkers of environmental pollution [15]. Previous studies have suggested that BPA, as an analog of estrogen, may exert an estrogenic effect on fish gonad development and reproductive axis-related gene expression [16][17][18][19][20]. BPA also affects various biological processes in fish, including metabolism, individual cortisol stress responses, energy metabolism, muscle structure, motor behavior, and axonal growth, thereby affecting fish growth and development [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the Effects of Bisphenol A on Dopamine Synthesis and Blood Vessels in the Goldfish Brain

Wang

Lin

et al. 2019

IJMS

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Bisphenol A (BPA) is an abundant contaminant found in aquatic environments. While a large number of toxicological studies have investigated the effects of BPA, the potential effects of BPA exposure on fish brain have rarely been studied. To understand how BPA impacts goldfish brains, we performed a transcriptome analysis of goldfish brains that had been exposed to 50 μg L−1 and 0 μg L−1 BPA for 30 days. In the analysis of unigene expression profiles, 327 unigenes were found to be upregulated and 153 unigenes were found to be downregulated in the BPA exposure group compared to the control group. Dopaminergic signaling pathway-related genes were significantly downregulated in the BPA exposure group. Furthermore, we found that serum dopamine concentrations decreased and TUNEL (terminal deoxynucleotidyl transferase 2-deoxyuridine, 5-triphosphate nick end labeling) staining was present in dopamine neurons enriched regions in the brain after BPA exposure, suggesting that BPA may disrupt dopaminergic processes. A KEGG analysis revealed that genes involved in the fluid shear stress and atherosclerosis pathway were highly significantly enriched. In addition, the qRT-PCR results for fluid shear stress and atherosclerosis pathway-related genes and the vascular histology of the brain showed that BPA exposure could damage blood vessels and induce brain atherosclerosis. The results of this work provide insights into the biological effects of BPA on dopamine synthesis and blood vessels in goldfish brain and could lay a foundation for future BPA neurotoxicity studies.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Assessment of the Effects of Bisphenol A on Dopamine Synthesis and Blood Vessels in the Goldfish Brain

Wang

Lin

et al. 2019

IJMS

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“…We also studied iodination of bis-phenols, where the two phenolic rings are not directly attached to each other. [39][40][41][42] This is an important class of compounds, especially in the polymer arena (e.g. bis-phenol A (BPA)).…”

Section: Resultsmentioning

confidence: 99%

Protecting Group-Controlled Remote Regioselective Electrophilic Aromatic Halogenation Reactions

Brittain

Cobb

2020

J. Org. Chem.

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Being able to utilise a protecting group to influence remote regiocontrol offers a simple alternative approach to direct late-stage functionalisation of complex organic molecules. However, protecting groups that have the ability to influence reaction regioselectivity remote to their local chemical environment are not widely reported in the literature. Herein, we report the development of remote regioselective electrophilic aromatic substitution (S E Ar) reactions that are enabled via the application of the tetrafluoropyridyl (TFP) phenol protecting group. We demonstrate that through sequential reactions and protection/deprotection of the TFP group, substitution patterns which do not conform to classical S E Ar regioselectivity rules can be readily accessed.

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“…The effects of TBBPA on fish reproduction is far less studied than that of BPA. Though studies have indicated that TBBPA can affect teleost reproductive success [28,30,31], there are no previous studies, known to us, looking at the higher levels of the BPG-axis in this animal group. Here, we demonstrate that TBBPA can stimulate pituitary cell viability and gene expression of gonadotropin β-subunits at acute, environmentally relevant concentrations.…”

Section: Tbbpamentioning

confidence: 90%

In Vitro Effects of Bisphenol A and Tetrabromobisphenol A on Cell Viability and Reproduction-Related Gene Expression in Pituitaries from Sexually Maturing Atlantic Cod (Gadus morhua L.)

Krogh

Ropstad

Nourizadeh-Lillabadi

et al. 2019

Fishes

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Bisphenol A (BPA) and tetrabromobisphenol A (TBBPA) are widely used industrial chemicals, ubiquitously present in the environment. While BPA is a well-known endocrine disruptor and able to affect all levels of the teleost reproductive axis, information regarding TBBPA on this subject is very limited. Using primary cultures from Atlantic cod (Gadus morhua), the present study was aimed at investigating potential direct effects of acute (72 h) BPA and TBBPA exposure on cell viability and the expression of reproductive-relevant genes in the pituitary. The results revealed that both bisphenols stimulate cell viability in terms of metabolic activity and membrane integrity at environmentally relevant concentrations. BPA had no direct effects on gonadotropin gene expression, but enhanced the expression of gonadotropin-releasing hormone (GnRH) receptor 2a, the main gonadotropin modulator in Atlantic cod. In contrast, TBBPA increased gonadotropin transcript levels but had no effect on GnRH receptor mRNA. In conclusion, both anthropogenic compounds display endocrine disruptive properties and are able to directly interfere with gene expression related to reproductive function in cod pituitary cells at environmentally relevant concentrations in vitro.

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Different effects of bisphenol a and its halogenated derivatives on the reproduction and development of Oryzias melastigma under environmentally relevant doses

Cited by 39 publications

References 37 publications

Assessment of the Effects of Bisphenol A on Dopamine Synthesis and Blood Vessels in the Goldfish Brain

Assessment of the Effects of Bisphenol A on Dopamine Synthesis and Blood Vessels in the Goldfish Brain

Protecting Group-Controlled Remote Regioselective Electrophilic Aromatic Halogenation Reactions

In Vitro Effects of Bisphenol A and Tetrabromobisphenol A on Cell Viability and Reproduction-Related Gene Expression in Pituitaries from Sexually Maturing Atlantic Cod (Gadus morhua L.)

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