Different effects of calcitriol and parathyroidectomy on the PTH--calcium curve in dialysis patients with severe hyperparathyroidism

Malberti, Fabio; Corradi, Bruno; Cosci, P.; Colecchia, M.; Leopardi, O.; Grossi, L.; Oldini, C.; Imbasciati, E

doi:10.1093/oxfordjournals.ndt.a027071

Cited by 5 publications

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“…Therefore, hemodialysis has become an important method for prolonging the lives of the affected patients. However, long-term illness and continuous hemodialysis lead to many complications, an example of which is uremic secondary hyperparathyroidism [1][2][3]. Uremic secondary hyperparathyroidism not only causes skin pruritus, renal anemia and decreased quality of sleep, but also accentuates cardiovascular calcification and increases mortality of patients.…”

Section: Introductionmentioning

confidence: 99%

Effect of combined vitamin D and microwave ablation of parathyroid glands on blood pressure and cardiac function in maintenance-hemodialysis patients with uremic secondary hyperparathyroidism

Zhu¹,

Li²,

Chen³

et al. 2022

Trop. J. Pharm Res

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Purpose: To investigate the effect of microwave ablation of parathyroid glands in combination with active vitamin D on blood pressure and cardiac function in maintenance-hemodialysis patients with uremic secondary hyperparathyroidism. Methods: One hundred and twenty maintenance-hemodialysis patients with uremic secondary hyperparathyroidism admitted to Meizhou People’s Hospital were assigned to 2 groups (A and B) in the order of their admission. Each group had 60 patients. Both groups were treated with active vitamin D, while patients in group A were, in addition, subjected to microwave ablation of parathyroid glands. Blood pressure, and indices for cardiac function, thyroid function s and anemia were determined. Results: After treatment, the blood pressure of group A was significantly lower than that of group B (p < 0.05). Moreover, after treatment, there were significant improvements in indices of cardiac function, thyroid function and anemia in group A patients, relative to group B patients. Conclusion: Microwave ablation of parathyroid glands, when combined with active vitamin D, improves blood pressure, cardiac function and anemia status. Furthermore, the combined therapy enhances recovery of thyroid function in maintenance-hemodialysis patients with uremic secondary hyperparathyroidism. However, the combined therapy should be subjected to further clinical trials prior to application in clinical practice. Keywords: Microwave ablation; Parathyroid glands; Active vitamin D; Hyperparathyroidism

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Section: Introductionmentioning

confidence: 99%