Different effects of essential tremor and Parkinsonian tremor on multiscale dynamics of hand tremor

Su, Dongning; Zhang, Fangzhao; Li, Zhu; Yang, Shuo; Wang, Ying; Ma, Huizi; Manor, Brad; Hausdorff, Jeffrey M.; Lipsitz, Lewis A.; Pan, Hua; Feng, Tao; Zhou, Junhong

doi:10.1016/j.clinph.2021.04.017

Cited by 10 publications

(13 citation statements)

References 31 publications

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“…Such age-related alterations can often be captured by the disrupted multiscale dynamics (i.e., loss of complexity) in the fluctuations of the spontaneous output signals of this system (25). Mounting evidence has suggested that compared to traditional single-scale measures (e.g., mean or variability), the complexity measures of the physiologic fluctuations can provide more insights into the multiscale nature of the regulation in the physiological procedures (7,8,10,21,(26)(27)(28)(29)(30). Numerous studies have linked the complexity metric to important functional performance and to the age-and disease-related subtle changes in physiologic systems, including the heartbeat series, standing postural sway fluctuation, brain activities as measured by electroencephalogram and functional MRI (7,8,10,21,(26)(27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

“…Mounting evidence has suggested that compared to traditional single-scale measures (e.g., mean or variability), the complexity measures of the physiologic fluctuations can provide more insights into the multiscale nature of the regulation in the physiological procedures (7,8,10,21,(26)(27)(28)(29)(30). Numerous studies have linked the complexity metric to important functional performance and to the age-and disease-related subtle changes in physiologic systems, including the heartbeat series, standing postural sway fluctuation, brain activities as measured by electroencephalogram and functional MRI (7,8,10,21,(26)(27)(28)(29)(30). For example, Rangasamy et al previously observed that lower preoperative BP complexity was associated with greater frailty in older adults after surgery (10).…”

Section: Discussionmentioning

confidence: 99%

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The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Links to Functions in Older Adults

Jiang

Cai

et al. 2022

Front. Cardiovasc. Med.

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BackgroundThe blood pressure (BP) is regulated by multiple neurophysiologic elements over multiple temporal scales. The multiscale dynamics of continuous beat-to-beat BP series, which can be characterized by “BP complexity”, may, thus, capture the subtle changes of those elements, and be associated with the level of functional status in older adults. We aimed to characterize the relationships between BP complexity and several important functions in older adults and to understand the underlying factors contributing to BP complexity.MethodA total of 400 older adults completed a series of clinical and functional assessments, a finger BP assessment of at least 10 min, and blood sample and vessel function tests. Their hypertensive characteristics, cognitive function, mobility, functional independence, blood composition, arterial stiffness, and endothelial function were assessed. The complexity of systolic (SBP) and diastolic (DBP) BP series was measured using multiscale entropy.ResultsWe observed that lower SBP and DBP complexity was significantly associated with poorer functional independence (β > 0.17, p < 0.005), cognitive function (β > 0.45, p = 0.01), and diminished mobility (β < −0.57, p < 0.003). Greater arterial stiffness (β < −0.48, p = 0.02), decreased endothelial function (β > 0.42, p < 0.03), and excessed level of blood lipids (p < 0.03) were the main contributors to BP complexity.ConclusionBlood pressure complexity is closely associated with the level of multiple functional statuses and cardiovascular health in older adults with and without hypertension, providing novel insights into the physiology underlying BP regulation. The findings suggest that this BP complexity metric would serve as a novel marker to help characterize and manage the functionalities in older adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Links to Functions in Older Adults

Jiang

Cai

et al. 2022

Front. Cardiovasc. Med.

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“…This likely explains the failure in detecting tremor progression using sensor‐based measures rather than what would be obtained by clinical ratings alone. 24 Nonetheless, detailed characterization of tremor features by means of sensors may be helpful in the differential diagnosis between tremor syndromes, 25 , 26 to predict therapeutic outcomes, 27 and to adapt deep‐brain stimulation (DBS) paradigms to individual tremor physiology. 28 , 29 It is, therefore, expected that transducers will be increasingly used in both clinical and research settings, also because they enable more frequent and/or longer tremor assessments, and they can be used almost anywhere without clinician raters and/or might be exploited to substantiate clinical ratings.…”

Section: Tremor Measurementmentioning

confidence: 99%

Milestones in Tremor Research: 10 Years Later

Erro

Fasano

Barone

et al. 2022

Movement Disord Clin Pract

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Major progress has occurred during the last decade in the field of tremor. From the clinical standpoint, a new classification has completely revised the nosology of tremor syndromes and has re‐conceptualized essential tremor as a syndrome rather than a single disease entity, fueling an ongoing enlightened debate. Significant advances have been obtained in terms of instrumental measurement of tremor, remarking on the possibility of developing novel treatment strategies based on tremor characteristics, namely tremor‐phase. Moreover, a better understanding of the pathophysiological mechanisms has further led to the suggestion of refining the classification of tremor syndromes according to their driving underpinnings. Finally, surgical options such as deep brain stimulation and focused ultrasound thalamotomy are now part of the therapeutic portfolio for tremor, but several oral drugs, including long‐chain alcohols, T‐channel blockers, allosteric modulators of potassium channels, and of GABA‐A receptors, are currently being tested and hold promise. This review will discuss the key milestones in tremor research of the last 10 years, with a focus on the most common tremor syndromes, namely essential tremor, dystonic tremor, and Parkinsonian tremor.

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“…The main focus of most tremor studies is detecting or comparing the tremor of different groups/conditions and extracting features of the whole signal [ 10 , 20 , 26 , 27 , 35 , 36 ]. However, to identify underlying patterns in tremor signals, it is necessary to track them since tremors change over time.…”

Section: Discussionmentioning

confidence: 99%

“…Tremors can also be characterized based on the affected body region, such as the upper or lower limb [ 9 ]. Many studies have focused on assessing hand tremors [ 10 , 11 , 12 , 13 , 14 ], which is the topic of this paper, regardless of the type of tremor, i.e., physiological or pathological. Hand tremors are caused by a number of physiological components, including the activity of the basal ganglia, cerebellar circuits, and peripheral nerves, all of which interact on different spatiotemporal scales.…”

Section: Introductionmentioning

confidence: 99%

Identification and Characterization of Short-Term Motor Patterns in Rest Tremor of Individuals with Parkinson’s Disease

et al. 2022

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(1) Background: The dynamics of hand tremors involve nonrandom and short-term motor patterns (STMPs). This study aimed to (i) identify STMPs in Parkinson’s disease (PD) and physiological resting tremor and (ii) characterize STMPs by amplitude, persistence, and regularity. (2) Methods: This study included healthy (N = 12, 60.1 ± 5.9 years old) and PD (N = 14, 65 ± 11.54 years old) participants. The signals were collected using a triaxial gyroscope on the dorsal side of the hand during a resting condition. Data were preprocessed and seven features were extracted from each 1 s window with 50% overlap. The STMPs were identified using the clustering technique k-means applied to the data in the two-dimensional space given by t-Distributed Stochastic Neighbor Embedding (t-SNE). The frequency, transition probability, and duration of the STMPs for each group were assessed. All STMP features were averaged across groups. (3) Results: Three STMPs were identified in tremor signals (p < 0.05). STMP 1 was prevalent in the healthy control (HC) subjects, STMP 2 in both groups, and STMP3 in PD. Only the coefficient of variation and complexity differed significantly between groups. (4) Conclusion: These results can help professionals characterize and evaluate tremor severity and treatment efficacy.

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Different effects of essential tremor and Parkinsonian tremor on multiscale dynamics of hand tremor

Cited by 10 publications

References 31 publications

The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Links to Functions in Older Adults

The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Links to Functions in Older Adults

Milestones in Tremor Research: 10 Years Later

Identification and Characterization of Short-Term Motor Patterns in Rest Tremor of Individuals with Parkinson’s Disease

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