Different Effects of His‐Au NCs and MES‐Au NCs on the Propagation of Pseudorabies Virus

Feng, Chenchen; Fang, Puxian; Zhou, Yanrong; Liu, Lingzhi; Fang, Liurong; Xiao, Shaobo; Liang, Jiangong

doi:10.1002/gch2.201800030

Cited by 13 publications

(7 citation statements)

References 66 publications

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“…Surface modification plays an important role in the antiviral activity of AuNCs; therefore, researchers modified the surface of AuNCs with two different materials-histidine and mercaptoethane sulfonate. Among these, histidine-stabilized AuNCs showed strong inhibition of the proliferation of pseudorabies virus (PRV) [101,102]. Therefore, AuNPs functionalized with different molecules play critical roles in antiviral activity.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

Antiviral Potential of Nanoparticles—Can Nanoparticles Fight Against Coronaviruses?

et al. 2020

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Infectious diseases account for more than 20% of global mortality and viruses are responsible for about one-third of these deaths. Highly infectious viral diseases such as severe acute respiratory (SARS), Middle East respiratory syndrome (MERS) and coronavirus disease (COVID-19) are emerging more frequently and their worldwide spread poses a serious threat to human health and the global economy. The current COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of 27 July 2020, SARS-CoV-2 has infected over 16 million people and led to the death of more than 652,434 individuals as on 27 July 2020 while also causing significant economic losses. To date, there are no vaccines or specific antiviral drugs to prevent or treat COVID-19. Hence, it is necessary to accelerate the development of antiviral drugs and vaccines to help mitigate this pandemic. Non-Conventional antiviral agents must also be considered and exploited. In this regard, nanoparticles can be used as antiviral agents for the treatment of various viral infections. The use of nanoparticles provides an interesting opportunity for the development of novel antiviral therapies with a low probability of developing drug resistance compared to conventional chemical-based antiviral therapies. In this review, we first discuss viral mechanisms of entry into host cells and then we detail the major and important types of nanomaterials that could be used as antiviral agents. These nanomaterials include silver, gold, quantum dots, organic nanoparticles, liposomes, dendrimers and polymers. Further, we consider antiviral mechanisms, the effects of nanoparticles on coronaviruses and therapeutic approaches of nanoparticles. Finally, we provide our perspective on the future of nanoparticles in the fight against viral infections.

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Section: Gold Nanoparticlesmentioning

confidence: 99%

Antiviral Potential of Nanoparticles—Can Nanoparticles Fight Against Coronaviruses?

et al. 2020

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“…His-Au NCs and MES-Au NCs were synthesized as previously reported method. 32,33 The high-resolution transmission electron microscopy (HR-TEM) analysis showed no obvious difference between His-Au NCs and MES-Au NCs in morphology ( Fig. S1a and b †).…”

Section: Resultsmentioning

confidence: 99%

“…In our previous work, 32 the effects of MES-stabilized Au NCs (MES-Au NCs) and histidine-stabilized Au NCs (His-Au NCs) on the propagation of pseudorabies virus were investigated. Occasionally, we found that the uorescence intensity of His-Au NCs could be enhanced aer adding MES.…”

Section: Introductionmentioning

confidence: 99%

A novel gold-nanocluster-based fluorescent sensor for detection of sodium 2-mercaptoethanesulfonate

Feng

et al. 2019

RSC Adv.

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“…5). In order to explore the effect of surface modification upon the antiviral performance of Au NCs, we synthesized two types of gold clusters with different surface modification: histidine stabilized Au NCs (His-Au NCs), and mercaptoethane sulfonate and histidine stabilized Au NCs (MES-Au NCs) [81]. It is His-Au NCs rather than MES-Au NCs that were found to strongly inhibit the proliferation of PRV, as indicated by the results of plaque assay, confocal microscopic analysis, quantitative real-time polymerase, Western blot assay, and chain reaction assay.…”

Section: Gold Nanoclustersmentioning

confidence: 99%

An overview of functional nanoparticles as novel emerging antiviral therapeutic agents

Chen

Liang

2020

Materials Science and Engineering: C

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163

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Research on highly effective antiviral drugs is essential for preventing the spread of infections and reducing losses. Recently, many functional nanoparticles have been shown to possess remarkable antiviral ability, such as quantum dots, gold and silver nanoparticles, nanoclusters, carbon dots, graphene oxide, silicon materials, polymers and dendrimers. Despite their difference in antiviral mechanism and inhibition efficacy, these functional nanoparticles-based structures have unique features as potential antiviral candidates. In this topical review, we highlight the antiviral efficacy and mechanism of these nanoparticles. Specifically, we introduce various methods for analyzing the viricidal activity of functional nanoparticles and the latest advances in antiviral functional nanoparticles. Furthermore, we systematically describe the advantages and disadvantages of these functional nanoparticles in viricidal applications. Finally, we discuss the challenges and prospects of antiviral nanostructures. This topic review covers 132 papers and will enrich our knowledge about the antiviral efficacy and mechanism of various functional nanoparticles.

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Different Effects of His‐Au NCs and MES‐Au NCs on the Propagation of Pseudorabies Virus

Cited by 13 publications

References 66 publications

Antiviral Potential of Nanoparticles—Can Nanoparticles Fight Against Coronaviruses?

Antiviral Potential of Nanoparticles—Can Nanoparticles Fight Against Coronaviruses?

A novel gold-nanocluster-based fluorescent sensor for detection of sodium 2-mercaptoethanesulfonate

An overview of functional nanoparticles as novel emerging antiviral therapeutic agents

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