Different effects of monophasic pulses and biphasic pulses applied by a bipolar stimulation electrode in the rat hippocampal CA1 region

Yuan, Yue; Zheng, Lvpiao; Feng, Zhouyan; Yang, Gangsheng

doi:10.1186/s12938-021-00862-y

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…The therapeutic efficacy of modulating waveform asymmetry may then require longer duration trains of stimulation, such as explored in the present study, or higher amplitudes within the safety limits. It should be noted that long-lasting depression of neural activity followed stimulation (figures 1-3), reminiscent of stimulation induced depression of neural excitability [79][80][81]. This may lead to reduced perceptual sensitivity to ICMS when delivered with short latency between stimulation [76].…”

Section: Implications For Neural Technologymentioning

confidence: 99%

Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation

Stieger¹,

Eles²,

Ludwig³

et al. 2022

J. Neural Eng.

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Objective: Neural prosthetics often use intracortical microstimulation (ICMS) for sensory restoration. To restore natural and functional feedback, we must first understand how stimulation parameters influence the recruitment of neural populations. ICMS waveform asymmetry modulates the spatial activation of neurons around an electrode at 10 Hz; however, it is unclear how asymmetry may differentially modulate population activity at frequencies typically employed in the clinic (e.g. 100 Hz). We hypothesized that stimulation waveform asymmetry would differentially modulate preferential activation of certain neural populations, and the differential population activity would be frequency-dependent. Approach: We quantified how asymmetric stimulation waveforms delivered at 10 Hz or 100 Hz for 30s modulated spatiotemporal activity of cortical layer II/III pyramidal neurons using in vivo two-photon and mesoscale calcium imaging in anesthetized mice. Asymmetry is defined in terms of the ratio of the duration of the leading phase to the duration of the return phase of charge-balanced cathodal- and anodal-first waveforms (i.e. longer leading phase relative to return has larger asymmetry). Main Results: Neurons within 40-60µm of the electrode display stable stimulation-induced activity indicative of direct activation, which was independent of waveform asymmetry. The stability of 72% of activated neurons and the preferential activation of 20-90 % of neurons depended on waveform asymmetry. Additionally, this asymmetry-dependent activation of different neural populations was associated with differential progression of population activity. Specifically, neural activity tended to increase over time during 10 hz stimulation for some waveforms, whereas activity remained at the same level throughout stimulation for other waveforms. During 100 Hz stimulation, neural activity decreased over time for all waveforms, but decreased more for the waveforms that resulted in increasing neural activity during 10 Hz stimulation. Significance: These data demonstrate that at frequencies commonly used for sensory restoration, stimulation waveform alters the pattern of activation of different but overlapping populations of excitatory neurons. The impact of these waveform specific responses on the activation of different subtypes of neurons as well as sensory perception merits further investigation.

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Section: Implications For Neural Technologymentioning

confidence: 99%

Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation

Stieger¹,

Eles²,

Ludwig³

et al. 2022

J. Neural Eng.

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“…The effect of commercial DBS system heavily depends on the parameters of the applied stimulation pulses, including the waveform, pulse width, frequency, and amplitude 41 , 42 . For the waveform, the monophasic pulses may generate toxic products by electrochemical reactions 43 , while charge-balanced biphasic pulses may prevent irreversible chemical reactions in the brain tissue around the electrode contacts 44 , 45 and are generally used in clinical DBS for safety. For the stimulation frequency, in comparison with low-frequency stimulation 46 , 47 , the high-frequency (>100 Hz) stimulation is an established medical treatment for PD motor symptoms 48 .…”

Section: Methodsmentioning

confidence: 99%

A longitudinal electrophysiological and behavior dataset for PD rat in response to deep brain stimulation

Wang,

Chen,

Shen

et al. 2024

Sci Data

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Here we presented an electrophysiological dataset collected from layer V of the primary motor cortex (M1) and the corresponding behavior dataset from normal and hemi-parkinson rats over 5 consecutive weeks. The electrophysiological dataset was constituted by the raw wideband signal, neuronal spikes, and local field potential (LFP) signal. The open-field test was done and recorded to evaluate the behavior variation of rats among the entire experimental cycle. We conducted technical validation of this dataset through sorting the spike data to form action potential waveforms and analyzing the spectral power of LFP data, then based on these findings a closed-loop DBS protocol was developed by the oscillation activity response of M1 LFP signal. Additionally, this protocol was applied to the hemi-parkinson rat for five consecutive days while simultaneously recording the electrophysiological data. This dataset is currently the only publicly available dataset that includes longitudinal closed-loop DBS recordings, which can be utilized to investigate variations of neuronal activity within the M1 following long-term closed-loop DBS, and explore additional reliable biomarkers.

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“…However, It should be noted that long-lasting depression of neural activity followed stimulation (Fig. 1-3), reminiscent of stimulation induced depression of neural excitability (SIDNE) (79)(80)(81). This may lead to reduced perceptual sensitivity to ICMS when delivered with short latency between stimulation(77).…”

Section: Implications For Neural Technologymentioning

confidence: 99%

Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation

Stieger

Eles

Ludwig

et al. 2022

Preprint

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Background: Neural prosthetics often use intracortical microstimulation (ICMS) for sensory restoration. To restore natural and functional feedback, we must first understand how stimulation parameters influence the recruitment of neural populations. ICMS waveform asymmetry modulates the spatial activation of neurons around an electrode at 10 Hz; however, it is unclear how asymmetry may differentially modulate population activity at frequencies typically employed in the clinic (e.g. 100 Hz). Objective: We hypothesized that stimulation waveform asymmetry would differentially modulate preferential activation of certain neural populations, and the differential population activity would be frequency-dependent. Methods: We quantified how asymmetric stimulation waveforms delivered at 10 Hz or 100 Hz for 30s modulated spatiotemporal activity of cortical layer II/III pyramidal neurons using in vivo two-photon and mesoscale calcium imaging in anesthetized mice. Asymmetry is defined in terms of the ratio of the leading phase to the return phase of charge-balanced cathodal- and anodal-first waveforms. Results: Neurons within 40-60 micron of the electrode display stable stimulation-induced activity indicative of direct activation, which was independent of waveform asymmetry. The stability of 72% of activated neurons and the preferential activation of 20-90 % of neurons depended on waveform asymmetry. Additionally, this asymmetry-dependent activation of different neural populations was associated with differential progression of population activity. Specifically, neural activity increased over time for some waveforms at 10 Hz, but decreased more at 100 Hz than other waveforms. Conclusion: These data demonstrate that at frequencies commonly used for sensory restoration, stimulation waveform alters the pattern of activation of different but overlapping populations of excitatory neurons. The impact of these waveform specific responses on the activation of different subtypes of neurons as well as sensory perception merits further investigation.

show abstract

Different effects of monophasic pulses and biphasic pulses applied by a bipolar stimulation electrode in the rat hippocampal CA1 region

Cited by 6 publications

References 35 publications

Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation

Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation

A longitudinal electrophysiological and behavior dataset for PD rat in response to deep brain stimulation

Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation

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