Different effects of tocolytic medication on blood pressure and blood pressure amplification

Pharmacokinetics, safety and tolerability of OBE022, a selective prostaglandin F2α receptor antagonist tocolytic: A first‐in‐human trial in healthy postmenopausal women

“…The prodrug was safe and well tolerated across all dosing regimens. Significant changes in vital signs were not observed in this trial, despite the previously reported blood pressure elevation in response to topical application of FP agonists [41] and the association of tocolytic medication with hypotensive effects [42,43]. After oral administration, the prodrug was readily transformed into its metabolite OBE002.…”

The influence of tocolytic drugs on cardiac function, large arteries, and resistance vessels

“…[10] We evaluated the acute effects of therapeutic doses of ritodrine and atosiban on blood pressure, cardiac function, micro-circulation (total peripheral resistance) and macro-circulation (large artery stiffness) in healthy non-pregnant female volunteers.…”