Different epigenetic mechanisms of ERα implicated in the fate of fulvestrant-resistant breast cancer

Tsuboi, Kouki; Kaneko, Yosuke; Nagatomo, Takao; Fujii, Rika; Hanamura, Toru; Gohno, Tatsuyuki; Yamaguchi, Yuri; Niwa, Toshimitsu; Hayashi, Shin Ichi

doi:10.1016/j.jsbmb.2016.11.017

Cited by 20 publications

(17 citation statements)

References 42 publications

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“…Furthermore, total exosome preparations were found to affect the DNA methylation in the recipient cells [ 37 ]. On the other side, the correlation between progression of tamoxifen resistance and methylation status of growth-associated genes in breast cancer is well established and demonstrated on the various models including MCF-7 cells [ 38 , 39 , 40 , 41 , 42 ]. We propose that single exosomal microRNA may be involved in the epigenetic DNA modifications resulting in the partial cell resistance.…”

Section: Discussionmentioning

confidence: 99%

Exosome-Mediated Transfer of Cancer Cell Resistance to Antiestrogen Drugs

Semina¹,

Scherbakov²,

Vnukova

et al. 2018

Molecules

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Exosomes are small vesicles which are produced by the cells and released into the surrounding space. They can transfer biomolecules into recipient cells. The main goal of the work was to study the exosome involvement in the cell transfer of hormonal resistance. The experiments were performed on in vitro cultured estrogen-dependent MCF-7 breast cancer cells and MCF-7 sublines resistant to SERM tamoxifen and/or biguanide metformin, which exerts its anti-proliferative effect, at least in a part, via the suppression of estrogen machinery. The exosomes were purified by differential ultracentrifugation, cell response to tamoxifen was determined by MTT test, and the level and activity of signaling proteins were determined by Western blot and reporter analysis. We found that the treatment of the parent MCF-7 cells with exosomes from the resistant cells within 14 days lead to the partial resistance of the MCF-7 cells to antiestrogen drugs. The primary resistant cells and the cells with the exosome-induced resistance were characterized with these common features: decrease in ERα activity and parallel activation of Akt and AP-1, NF-κB, and SNAIL1 transcriptional factors. In general, we evaluate the established results as the evidence of the possible exosome involvement in the transferring of the hormone/metformin resistance in breast cancer cells.

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Section: Discussionmentioning

confidence: 99%

Exosome-Mediated Transfer of Cancer Cell Resistance to Antiestrogen Drugs

Semina¹,

Scherbakov²,

Vnukova

et al. 2018

Molecules

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“…52 During the normal oestrus cycle, the breast undergoes cyclic rounds of growth and involution. 54,55 Involution is mediated by a decrease in calcium-dependent PCCA2 channel activity, resulting in elevation of cytosolic calcium levels and subsequent apoptosis. 54,55 Involution is mediated by a decrease in calcium-dependent PCCA2 channel activity, resulting in elevation of cytosolic calcium levels and subsequent apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…53 Oestrogens exert a proliferative effect through ligandinduced and ligand-independent activation of transcription factors (Fos/Jun, SP-1), resulting in protein synthesis and cell growth. 54,55 Involution is mediated by a decrease in calcium-dependent PCCA2 channel activity, resulting in elevation of cytosolic calcium levels and subsequent apoptosis. 56…”

Section: Discussionmentioning

confidence: 99%

Calcium channel blockers and the incidence of breast and prostate cancer: A meta-analysis

et al. 2018

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Although a statistically significant association between CCB use and incidence of BCa does exist, the limitations of the individual studies restrict the clinical application of this relationship. Our meta-regression model does newly identify a 9-year latency period of CCB use and a significantly increased risk of BCa. No significant association exists between CCB use and the incidence of PCa. Our meta-regression shows CCB may have a protective effect upon PCa incidence among older populations.

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“…miRNAs may play acritical role also in resistance to fulvestrant ( Table 6 ) that is used as asecond-line therapy in cases of metastatic BC [ 120 ]. Acquired fulvestrant resistance is an ERα independent condition with alteration of growth hormone pathways, glycoprotein 88 overexpression [ 121 ], and functional methylation of the ER promoter region [ 120 , 122 ]. miR-143, miR-145, miR-137, miR-424, miR-21 may play important roles in fulvestrant resistance as well as miR-221/222, which is upregulated in fulvestrant-resistant cancer cell lines [ 123 , 124 , 125 ].…”

Section: Mirnas and Their Role In Endocrine Resistancementioning

confidence: 99%

miRNA Expression Profiles in Luminal A Breast Cancer—Implications in Biology, Prognosis, and Prediction of Response to Hormonal Treatment

Kúdela

Samec

Koklesová

et al. 2020

IJMS

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Breast cancer, which is the most common malignancy in women, does not form a uniform nosological unit but represents a group of malignant diseases with specific clinical, histopathological, and molecular characteristics. The increasing knowledge of the complex pathophysiological web of processes connected with breast cancercarcinogenesis allows the development of predictive and prognostic gene expressionand molecular classification systems with improved risk assessment, which could be used for individualized treatment. In our review article, we present the up-to-date knowledge about the role of miRNAs and their prognostic and predictive value in luminal A breast cancer. Indeed, an altered expression profile of miRNAs can distinguish not only between cancer and healthy samples, but they can classify specific molecular subtypes of breast cancer including HER2, Luminal A, Luminal B, and TNBC. Early identification and classification of breast cancer subtypes using miRNA expression profilescharacterize a promising approach in the field of personalized medicine. A detection of sensitive and specific biomarkers to distinguish between healthy and early breast cancer patients can be achieved by an evaluation of the different expression of several miRNAs. Consequently, miRNAs represent a potential as good diagnostic, prognostic, predictive, and therapeutic biomarkers for patients with luminal A in the early stage of BC.

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Different epigenetic mechanisms of ERα implicated in the fate of fulvestrant-resistant breast cancer

Cited by 20 publications

References 42 publications

Exosome-Mediated Transfer of Cancer Cell Resistance to Antiestrogen Drugs

Exosome-Mediated Transfer of Cancer Cell Resistance to Antiestrogen Drugs

Calcium channel blockers and the incidence of breast and prostate cancer: A meta-analysis

miRNA Expression Profiles in Luminal A Breast Cancer—Implications in Biology, Prognosis, and Prediction of Response to Hormonal Treatment

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