Different expression of cytokine and membrane molecules by circulating lymphocytes on acute mental stress in patients with atopic dermatitis in comparison with healthy controls

Schmid-Ott, ­Gerhard; Jaeger, Burkard; Meyera, b Silke; Stephana, b Elisabeth; Kapp, Alexander; Werfel, Thomas

doi:10.1067/mai.2001.117800

Cited by 80 publications

(55 citation statements)

References 44 publications

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“…This finding was unexpected but probably induced by the stress associated with blood collection leading to the increased subpopulation of T lymphocytes, eosinophils and natural killer cells [31]. This is likely to be explained in a similar way as Hoffman et al[ 30] have done in their study, in which they demonstrated an increase in CD25+ on T cells after placebo, and they associated it with the recruitment of activated T cells from the circulation to the site of allergen exposure.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Receptor Expression on Immune System Cells in the Peripheral Blood of Asthmatic Children Undergoing Food Challenges

Krogulska

Wąsowska-Królikowska²,

Polakowska³

et al. 2009

Int Arch Allergy Immunol

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Background: The role of food allergens in the induction of allergic reactions in the airways is not completely understood. The aim of the present study was to evaluate fluorocytometric assays of the peripheral blood during food challenge tests in children with asthma and food allergy. Patients and Methods: 22 children with asthma and concomitant food allergy and 18 children with asthma without food allergy participated in the study. Oral challenge tests were performed using double-blind, placebo-controlled food challenge. Blood samples were collected before and 4 and 24 h after the challenge. CD25 and CD23 antigen expression was determined with monoclonal antibodies using a FACSCalibur flow. Results: The evaluation of the CD25+ T subpopulation and CD19+CD23+ B lymphocytes revealed statistically significant differences between the study group and the control group. In children with asthma and food allergy, the cell pool consisted (on average) of 9 ± 2.8% of CD3+CD25+ cells before the challenge and of 10.3 ± 3.8% (mean delta: 1.623; p = 0.01) after the provocation. However, placebo challenge did not significantly change the number of this T-lymphocyte subpopulation (mean delta: –0.121; p > 0.05). The highest increase in the CD25+ T-subpopulation expression was found in patients with respiratory reactions during the positive food challenge (mean delta: 4.065; p < 0.004). Conclusions: An increase in CD25+ T-lymphocyte and CD23 B-lymphocyte populations after food allergen challenge may indicate their significant role in the pathogenesis of the active phase of the immunoinflammatory process in children with asthma and concomitant food allergy.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Receptor Expression on Immune System Cells in the Peripheral Blood of Asthmatic Children Undergoing Food Challenges

Krogulska

Wąsowska-Królikowska²,

Polakowska³

et al. 2009

Int Arch Allergy Immunol

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“…[52][53][54] Injury by tape stripping, acetone treatment, or UV irradiation of mammalian skin induces a variety of acute responses, including erythema, hyperplasia, an increase in the number of inflammatory cells, and hyperproliferation. 55) The form and arrangement of surface corneocytes reflect cellular organization within the epidermis and are a good index of proliferation and differentiation-induction potency.…”

Section: Discussionmentioning

confidence: 99%

Study of Active Substances Involved in Skin Dysfunction Induced by Crowding Stress. I. Effect of Crowding and Isolation on Some Physiological Variables, Skin Function and Skin Blood Perfusion in Hairless Mice.

Ishida

Mitsui

Nukaya

et al. 2003

Biological & Pharmaceutical Bulletin

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Human skin functions not only as a barrier to retain the internal components and to protect internal organs from external stimulation or invasion, but also as a sensory organ to maintain homeostasis. In addition, it plays important roles in processes such as thermoregulation, antibody formation, vitamin D formation, lipid secretion, respiration, pigmentation and perception. [1][2][3][4][5][6] Stress disturbs the homeostasis, and may induce various disorders. For example, various kinds of physiological and psychological stress influence the hypothalamic-pituitaryadrenocortical axis, the hypothalamic-pituitary-gonadal axis, sympatho-adrenomedullary system and sympathetic nervous system, leading to changes in a number of organs. Stress has been implicated in hypertension, arteriosclerosis, diabetes mellitus, and other diseases in clinical and epidemiological studies.7) Skin function should also be influenced by stress, because it is primarily regulated by the autonomic nervous system and the endocrine system. This idea is supported by clinical reports showing that some skin disorders, including psoriasis and atopic dermatitis, are exacerbated by anxiety. 8)In addition, recent cutaneous biological studies have revealed that immobilization stress and/or overcrowding stress induced a decrease in lipogenesis in sebaceous glands, delay of skin barrier recovery and disruption of the skin barrier in rats, Syrian hamsters, and/or BALB/c mice.9-11) Barrier function and water retention are important cutaneous functions to maintain homeostasis. However, the relationship between stressful stimuli and skin dysfunction has not been established yet.Psychological stress activates the sympathetic nervous system, resulting in increases in the levels of glucocorticoids, catecholamines and angiotensin II in the circulating blood. Excess of glucocorticoid and angiotensin II can elevate blood pressure and excess of catecholamine increases cardiac output and peripheral resistance. Thus, stress induces acute hypertonic and chronic circulatory disorders. Hypertension causes hematogeneous disorder in the microvasculature. Therefore, concomitant reduced blood supply may contribute to peripheral ischemia. It is also suggested that mental stress induces transient endothelial dysfunction in humans. 12) Indeed, it is well recognized that psychological stress elevates blood pressure and that long-term stress causes dysfunction of the skin and various organs, such as ovary, kidney, thymus and adrenal glands.Recently, the laser Doppler perfusion-imaging technique has made it possible to map accurately changes of blood perfusion over a large area with good time resolution, and this method has been used to measure microcirculatory changes of the skin, mucosa, kidney and eye. 13,14) It has also been used for detecting abnormal blood flow in pathologically changed skin. 15)In this study, we have examined the relationship between blood perfusion and skin dysfunction mediated by catecholamines in animals exposed to a crowded environment. This approach ha...

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“…There are a number of ways in which psychological stress may affect the body, e.g., via increased cortisol as well as catecholamine concentrations (11,21). Recently, stress has been associated with the development of allergies (22) and has been shown to influence the functional profile of T-cells (22)(23)(24). Furthermore, stress has been shown to modify the outcome of immunization in humans (25).…”

Section: Ethical Considerationsmentioning

confidence: 99%

Psychological Stress May Induce Diabetes-Related Autoimmunity in Infancy

et al. 2005

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OBJECTIVE -In retrospective studies, a number of disparate environmental factors (including experiences of serious life events) have been proposed as trigger mechanisms for type 1 diabetes or the autoimmune process behind the disease. Psychosocial stress in families may affect children negatively due to a link to hormonal levels and nervous signals that in turn influence both insulin sensitivity/insulin need and the immune system. Our aim was to investigate whether psychological stress, measured as psychosocial strain in families, is associated with diabetesrelated autoimmunity during infancy.RESEARCH DESIGN AND METHODS -The first 4,400 consecutive 1-year-old children from a large prospective population-based project participated in the study. Parents completed questionnaires at birth and at 1 year, including various measures of psychosocial stress (e.g., parenting stress) and sociodemographic background. Blood samples drawn from the children at 1 year were analyzed for type 1 diabetes-associated autoantibodies toward tyrosine phosphatase and GAD. Antibodies toward tetanus toxoid were used as non-diabetes-related control antibodies. RESULTS -Psychosocial factors, i.e., high parenting stress (odds ratio 1.8 [95% CI 1.2-2.9], P Ͻ 0.01), experiences of a serious life event (2.3 [1.3-4.0], P Ͻ 0.01), foreign origin of the mother (2.1 [1.3-3.3], P Ͻ 0.001), and low paternal education (1.6 [1.1-2.3], P Ͻ 0.01) were associated with diabetes-related autoimmunity in the child, independent of family history of diabetes.CONCLUSIONS -Psychological stress, measured as psychosocial strain in the family, seems to be involved in the induction, or progression, of diabetes-related autoimmunity in the child during the 1st year of life. Diabetes Care 28:290 -295, 2005

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Different expression of cytokine and membrane molecules by circulating lymphocytes on acute mental stress in patients with atopic dermatitis in comparison with healthy controls

Cited by 80 publications

References 44 publications

Evaluation of Receptor Expression on Immune System Cells in the Peripheral Blood of Asthmatic Children Undergoing Food Challenges

Evaluation of Receptor Expression on Immune System Cells in the Peripheral Blood of Asthmatic Children Undergoing Food Challenges

Study of Active Substances Involved in Skin Dysfunction Induced by Crowding Stress. I. Effect of Crowding and Isolation on Some Physiological Variables, Skin Function and Skin Blood Perfusion in Hairless Mice.

Psychological Stress May Induce Diabetes-Related Autoimmunity in Infancy

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