Different Expression of Micro-RNA in the Subcutaneous and Visceral Adipose Tissue of Obese Subjects

Lacedonia, Donato; Tartaglia, Nicola; Scioscia, Giulia; Soccio, Piera; Pavone, Giovanna; Moriondo, Giorgia; Gallo, Crescenzio; Barbaro, Maria Pia Foschino; Ambrosi, Antonio

doi:10.1089/rej.2022.0004

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…Recent studies have shown that miR-483-5p plays a significant role in regulating adipogenesis. The expression of miR-483-5p is significantly downregulated in subcutaneous adipose tissue obtained from human subjects with obesity compared to those without obesity [ 41 ] ( Table 1 ). MiR-483-5p positively regulates the expression of PPARγ and facilitates adipogenesis in mouse pre-adipocyte 3T3-L1 cells and human adipose-derived MSCs by targeting ERK1 [ 42 , 53 ].…”

Section: Role Of Mir-483-5p In Diabetesmentioning

confidence: 99%

Impacts of MicroRNA-483 on Human Diseases

Matson,

Macleod,

Mehta

et al. 2023

ncRNA

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MicroRNAs (miRNAs) are short non-coding RNA molecules that regulate gene expression by targeting specific messenger RNAs (mRNAs) in distinct cell types. This review provides a com-prehensive overview of the current understanding regarding the involvement of miR-483-5p and miR-483-3p in various physiological and pathological processes. Downregulation of miR-483-5p has been linked to numerous diseases, including type 2 diabetes, fatty liver disease, diabetic nephropathy, and neurological injury. Accumulating evidence indicates that miR-483-5p plays a crucial protective role in preserving cell function and viability by targeting specific transcripts. Notably, elevated levels of miR-483-5p in the bloodstream strongly correlate with metabolic risk factors and serve as promising diagnostic markers. Consequently, miR-483-5p represents an appealing biomarker for predicting the risk of developing diabetes and cardiovascular diseases and holds potential as a therapeutic target for intervention strategies. Conversely, miR-483-3p exhibits significant upregulation in diabetes and cardiovascular diseases and has been shown to induce cellular apoptosis and lipotoxicity across various cell types. However, some discrepancies regarding its precise function have been reported, underscoring the need for further investigation in this area.

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Section: Role Of Mir-483-5p In Diabetesmentioning

confidence: 99%

Impacts of MicroRNA-483 on Human Diseases

Matson,

Macleod,

Mehta

et al. 2023

ncRNA

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show abstract

“…miR-128-1 may be a valuable target for obesity management [68]. The expression of miR-483-5p is significantly decreased in the subcutaneous adipose tissue of obese compared to non-obese individuals [69]. miR-483-5p targets ERK1 and positively regulates PPARγ expression and promotes adipogenesis in mouse preadipocyte 3T3-L1 cells and human adipose-derived MSCs [56,70].…”

Section: Mirnas and Obesitymentioning

confidence: 99%

MicroRNAs and Nonalcoholic Steatohepatitis: A Review

Morishita,

Oura,

Tadokoro

et al. 2023

IJMS

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Non-alcoholic fatty liver disease (NAFLD) is a clinicopathologic syndrome caused by fat deposition in hepatocytes. Patients with nonalcoholic steatohepatitis (NASH), an advanced form of NAFLD with severe fibrosis, are at high risk for liver-related complications, including hepatocellular carcinoma (HCC). However, the mechanism of progression from simple fat deposition to NASH is complex, and previous reports have linked NAFLD to gut microbiota, bile acids, immunity, adipokines, oxidative stress, and genetic or epigenetic factors. NASH-related liver injury involves multiple cell types, and intercellular signaling is thought to be mediated by extracellular vesicles. MicroRNAs (miRNAs) are short, noncoding RNAs that play important roles as post-transcriptional regulators of gene expression and have been implicated in the pathogenesis of various diseases. Recently, many reports have implicated microRNAs in the pathogenesis of NALFD/NASH, suggesting that exosomal miRNAs are potential non-invasive and sensitive biomarkers and that the microRNAs involved in the mechanism of the progression of NASH may be potential therapeutic target molecules. We are interested in which miRNAs are involved in the pathogenesis of NASH and which are potential target molecules for therapy. We summarize targeted miRNAs associated with the etiology and progression of NASH and discuss each miRNA in terms of its pathophysiology, potential therapeutic applications, and efficacy as a NASH biomarker.

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“…Proteomic analysis showed that obesity had a greater impact on the protein profile of SAT-derived exosomes than VAT-derived exosomes in DIO mice, and the differentially expressed proteins in SAT and VAT were mainly involved in metabolic processes, such as fatty acid metabolism [ 29 ]. In addition, some miRNAs play a role in the pathogenesis of obesity-related cardiovascular and respiratory diseases, and these miRNAs were found to be significantly differentially expressed in SAT and VAT in obese individuals, suggesting that there are differences in transcriptional regulation in SAT and VAT [ 30 ]. However, the characteristics and changing patterns of tsRNA expression in SAT and VAT are not clear.…”

Section: Introductionmentioning

confidence: 99%

tsRNA Landscape and Potential Function Network in Subcutaneous and Visceral Pig Adipose Tissue

Wang

Liao

Lei

et al. 2023

Genes

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Noncoding RNAs (ncRNAs) called tsRNAs (tRNA-derived short RNAs) have the ability to regulate gene expression. The information on tsRNAs in fat tissue is, however, limited. By sequencing, identifying, and analyzing tsRNAs using pigs as animal models, this research reports for the first time the characteristics of tsRNAs in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). A total of 474 tsRNAs, 20 and 21 of which were particularly expressed in VAT and SAT, respectively, were found in WAT. According to the analysis of the tsRNA/miRNA/mRNA co-expression network, the tsRNAs with differential expression were primarily engaged in the endocrine and immune systems, which fall under the classification of organic systems, as well as the global and overview maps and lipid metropolis, which fall under the category of metabolism. This research also discovered a connection between the activity of the host tRNA engaged in translation and the production of tsRNAs. This research also discovered that tRF-Gly-GCC-037/tRF-Gly-GCC-042/tRF-Gly-CCC-016 and miR-218a/miR281b may be involved in the regulation of fatty acid metabolism in adipose tissue through SCD based on the tsRNA/miRNA/mRNA/fatty acid network. In conclusion, our findings enrich the understanding of ncRNAs in WAT metabolism and health regulation, as well as reveal the differences between SAT and VAT at the level of tsRNAs.

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Different Expression of Micro-RNA in the Subcutaneous and Visceral Adipose Tissue of Obese Subjects

Cited by 5 publications

References 19 publications

Impacts of MicroRNA-483 on Human Diseases

Impacts of MicroRNA-483 on Human Diseases

MicroRNAs and Nonalcoholic Steatohepatitis: A Review

tsRNA Landscape and Potential Function Network in Subcutaneous and Visceral Pig Adipose Tissue

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