Different Functional and Microstructural Changes Depending on Duration of Mild Cognitive Impairment in Parkinson Disease

Shin, Na Young; Shin, Yu-Bin; Lee, P. H.; Yoon, Uicheul; Han, Sanghoon; Kim, Dong Joon; Lee, S. K.

doi:10.3174/ajnr.a4626

Cited by 23 publications

(25 citation statements)

References 42 publications

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“…Cortical thickness values may reflect several characteristics of intracortical morphology [41] and correlations between regions as demonstrated in our findings imply structural connectivity. However, these and similar data do not necessarily index physiological connectivity or activation patterns among networks in clinical populations [42]. Therefore, our results cannot be regarded as a definitive test of the importance of the central executive network in schizophrenia or in relation to cognitive impairment.…”

Section: Discussionmentioning

confidence: 83%

Cortical Thinning in Network-Associated Regions in Cognitively Normal and Below-Normal Range Schizophrenia

Heinrichs

Pinnock

Parlar

et al. 2017

Schizophrenia Research and Treatment

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This study assessed whether cortical thickness across the brain and regionally in terms of the default mode, salience, and central executive networks differentiates schizophrenia patients and healthy controls with normal range or below-normal range cognitive performance. Cognitive normality was defined using the MATRICS Consensus Cognitive Battery (MCCB) composite score (T = 50 ± 10) and structural magnetic resonance imaging was used to generate cortical thickness data. Whole brain analysis revealed that cognitively normal range controls (n = 39) had greater cortical thickness than both cognitively normal (n = 17) and below-normal range (n = 49) patients. Cognitively normal controls also demonstrated greater thickness than patients in regions associated with the default mode and salience, but not central executive networks. No differences on any thickness measure were found between cognitively normal range and below-normal range controls (n = 24) or between cognitively normal and below-normal range patients. In addition, structural covariance between network regions was high and similar across subgroups. Positive and negative symptom severity did not correlate with thickness values. Cortical thinning across the brain and regionally in relation to the default and salience networks may index shared aspects of the psychotic psychopathology that defines schizophrenia with no relation to cognitive impairment.

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Section: Discussionmentioning

confidence: 83%

Cortical Thinning in Network-Associated Regions in Cognitively Normal and Below-Normal Range Schizophrenia

Heinrichs

Pinnock

Parlar

et al. 2017

Schizophrenia Research and Treatment

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“…Moreover, our colleagues recently reported a significant association between decreased fronto-striatal rsFC and a shorter duration of parkinsonism before MCI diagnosis in PD patients. The authors also found microstructural changes in the frontal white matter in PD-MCI patients with shorter disease duration, suggesting that the frontal area plays a pivotal role in deciding the rate of cognitive decline 27 . Our results also show an association between decreased rsFC in the frontal area and early cognitive decline in PD patients.…”

Section: Discussionmentioning

confidence: 89%

Early-onset mild cognitive impairment in Parkinson’s disease: Altered corticopetal cholinergic network

Kim¹,

Shin²,

Bak³

et al. 2017

Sci Rep

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Degeneration of the substantia innominata (SI) is significantly correlated with cognitive performance in Parkinson’s disease (PD). We examined functional and structural patterns of SI degeneration in drug-naïve PD patients according to the duration of parkinsonism before mild cognitive impairment (MCI) diagnosis. Twenty PD patients with a shorter duration (PD-MCI-SD, <1 year), 18 patients with a longer duration (PD-MCI-LD, ≥1 year), and 29 patients with intact cognition (PD-IC) were included. Seed-based resting-state functional connectivity (rsFC) analysis using bilateral SI seed and region-of-interest-based volumetric analysis were performed. Compared to PD-IC, the collapsed PD-MCI group showed altered rsFC in the right frontal and bilateral parietal areas. PD-MCI-SD showed rsFC alteration in broader frontal and parietal areas compared to the other groups. Decreased rsFC in the right frontal area was also significantly correlated with shorter disease duration. No significant SI volume change was found between the groups. Altered rsFC between the SI and the frontal and parietal areas might be relevant to cognitive dysfunction in PD. Decreased rsFC between the SI and frontal area might be associated with early-onset MCI, suggesting that cholinergic deficits in the frontal brain areas might play an important role in the acceleration of cognitive decline in PD.

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“…). Sensitivity analysis indicated to exclude 2 studies having a high risk of bias. After the exclusion of these primary studies the prevalence estimates remained stable (40%; n = 6813; 95% CI = 36–45; Q = 409.05, P < 0.0001; I 2 = 90.71%).…”

Section: Resultsmentioning

confidence: 99%

“…Sex. A total of 3 27,52,54 of 35 studies 4,5,11,12,14,15,[26][27][28][29][30][31][32][34][35][36][37][38][39][40][41][42][43][44][45][46][47][49][50][51][52][53][54]56,57 found an association between PD-MCI and male sex ( Supplementary Material 4). Our meta-analysis revealed a significant association between male sex and the occurrence of PD-MCI ( 4,10,12,14,33,38,39,[41][42][43]45,47,57 found an association between PD-MCI and a lower level of education ( Supplementary Material 4).…”

Section: Association With Demographic Characteristicsmentioning

confidence: 99%

Prevalence and Clinical Aspects of Mild Cognitive Impairment in Parkinson's Disease: A Meta‐Analysis

et al. 2019

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Mild cognitive impairment associated with Parkinson's disease (PD) is a risk factor for the development of dementia. Despite the importance of early identification of mild cognitive impairment in PD, its prevalence and clinical correlates are still debated. The present meta‐analysis provides a robust estimate of prevalence rate of mild cognitive impairment in PD according to the Movement Disorder Society clinical criteria and to explore the differences between PD patients with and without mild cognitive impairment in demographic, clinical, and neuropsychiatric features. A systematic literature search was performed up to April 2019 using PsycInfo (PROQUEST), PubMed, and Scopus. From 4706 titles and abstracts, 41 studies were selected (n = 7053 patients). Pooled mild cognitive impairment prevalence was 40% on a total sample of 7053 PD patients (95% confidence interval = 36–44; Q = 490.14, P < 0.0001; I2 = 91.84%) with a higher frequency for the multiple domain subtype (31%; 95% confidence interval = 23–41, Q = 93.24; P < 0.0001; I2 = 92.49%). Meta‐regression analysis revealed that stage of PD moderate prevalence estimates of mild cognitive impairment (β = 2.80; P = 0.008). Mild cognitive impairment in PD was associated with older age, lower education, longer disease duration, higher levodopa equivalent daily dose, more severe motor symptoms, and postural instability/gait difficulty motor subtype, poorer quality of life, higher levels of apathy, and depression. The present meta‐analysis indicated that mild cognitive impairment in PD is a frequent cognitive status deserving to be early detected by means of standardized cognitive assessments in clinical practice. © 2019 International Parkinson and Movement Disorder Society

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Different Functional and Microstructural Changes Depending on Duration of Mild Cognitive Impairment in Parkinson Disease

Cited by 23 publications

References 42 publications

Cortical Thinning in Network-Associated Regions in Cognitively Normal and Below-Normal Range Schizophrenia

Cortical Thinning in Network-Associated Regions in Cognitively Normal and Below-Normal Range Schizophrenia

Early-onset mild cognitive impairment in Parkinson’s disease: Altered corticopetal cholinergic network

Prevalence and Clinical Aspects of Mild Cognitive Impairment in Parkinson's Disease: A Meta‐Analysis

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