Different iron-handling in inflamed small and large cholangiocytes and in small and large-duct type intrahepatic cholangiocarcinoma

Mancinelli, Romina; Cutone, Antimo; Rosa, Luigi; Lepanto, Maria Stefania; Onori, Paolo; Pannarale, Luigi; Franchitto, Antonio; Gaudio, Eugenio; Valenti, Piera

doi:10.4081/ejh.2020.3156

Cited by 3 publications

(2 citation statements)

References 65 publications

(92 reference statements)

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“…3). Several commonly used clinical blood parameters were independently associated with survival in our ICC patients, 31,32 The strengths of our study are the well-characterized cohorts of patients with pathology-proven ICC, the follow-up data on the survival outcome, sample size, and the broader applicability. However, we acknowledge several limitations.…”

Section: Discussionmentioning

confidence: 99%

A New Prognostic Model Covering All Stages of Intrahepatic Cholangiocarcinoma

Zhou¹,

Lu²,

Ju³

et al. 2021

J Clin Transl Hepatol

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Background and Aims: Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy that causes a poor survival. We aimed to identify its prognostic factors and to develop a nomogram that will predict survival of ICC patients among all stages. Methods: A total of 442 patients with pathology-proven ICC registered at the Fifth Medical Center of PLA General Hospital between July 2007 and December 2019 were enrolled. Subjects were followed for survival status until June 30, 2020. A prognostic model visualized as a nomogram was constructed in the training cohort using multivariate cox model, and was then validated in the validation cohort. Results: The median age was 55 years. With a median follow-up of 50.4 months, 337 patients died. The median survival was 11.6 months, with 1-, 3-and 5-year survival rates of 48.3%, 22.7% and 16.2%, respectively. Factors associated with overall survival were multiple tumors, lymph node involvement, vascular invasion, distant metastasis, decreased albumin, elevated lactate dehydrogenase (LDH), decreased iron, elevated fibrinogen, elevated CA125 and elevated CA19-9. A nomogram predicting survival of ICC patients at the time of diagnosis achieved a Harrel's c-statistic of 0.758, significantly higher than the 0.582 of the TNM stage alone. Predicted median survivals of those within the low, mid and high-risk subgroups were 35.6, 12.1 and 6.2 months, respectively. Conclusions: A nomogram based on imaging data and serum biomarkers at diagnosis showed good ability to predict survival in patients with all stages of ICC. Further studies are needed to validate the prognostic capability of our new model.

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Section: Discussionmentioning

confidence: 99%

A New Prognostic Model Covering All Stages of Intrahepatic Cholangiocarcinoma

Zhou¹,

Lu²,

Ju³

et al. 2021

J Clin Transl Hepatol

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“…In particular, Fpn expression was found to be increased in small-duct-type iCCA, whereas TfR1 and Ft were upregulated in both iCCA subtypes, although to a limited extent in large-duct-type iCCA. Hepcidin levels were also elevated in every type of iCCA; a possible explanation is related to the dependence of its activation on interleukin-6 (IL-6), which is commonly upregulated in CCA [96].…”

Section: Iron Metabolismmentioning

confidence: 99%

The Emerging Role of Tumor Microenvironmental Stimuli in Regulating Metabolic Rewiring of Liver Cancer Stem Cells

Correnti

Binatti

Gammella

et al. 2022

Cancers

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Primary liver cancer (PLC) is one of the most devastating cancers worldwide. Extensive phenotypical and functional heterogeneity is a cardinal hallmark of cancer, including PLC, and is related to the cancer stem cell (CSC) concept. CSCs are responsible for tumor growth, progression, relapse and resistance to conventional therapies. Metabolic reprogramming represents an emerging hallmark of cancer. Cancer cells, including CSCs, are very plastic and possess the dynamic ability to constantly shift between different metabolic states depending on various intrinsic and extrinsic stimuli, therefore amplifying the complexity of understanding tumor heterogeneity. Besides the well-known Warburg effect, several other metabolic pathways including lipids and iron metabolism are altered in PLC. An increasing number of studies supports the role of the surrounding tumor microenvironment (TME) in the metabolic control of liver CSCs. In this review, we discuss the complex metabolic rewiring affecting liver cancer cells and, in particular, liver CSCs. Moreover, we highlight the role of TME cellular and noncellular components in regulating liver CSC metabolic plasticity. Deciphering the specific mechanisms regulating liver CSC–TME metabolic interplay could be very helpful with respect to the development of more effective and innovative combinatorial therapies for PLC treatment.

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Twenty years of histochemistry in the third millennium, browsing the scientific literature

Pellicciari¹

2020

Eur J Histochem

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Over the last twenty years, about 240,000 articles where histochemical techniques were used have been published in indexed journals, and their yearly number has progressively increased. The histochemical approach was selected by researchers with very different scientific interests, as the journals in which these articles were published fall within 140 subject categories. The relative proportion of articles in some of these journal categories did change over the years, and browsing the table of contents of the European Journal of Histochemistry, as an example of a strictly histochemical journal, it appeared that in recent years histochemical techniques were preferentially used to mechanistically investigate natural or experimentally induced dynamic processes, with reduced attention to purely descriptive works. It may be foreseen that, in the future, histochemistry will be increasingly focused on studying the molecular pathways responsible for cell differentiation, the maintenance or loss of the differentiated state, and tissue regeneration.

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Different iron-handling in inflamed small and large cholangiocytes and in small and large-duct type intrahepatic cholangiocarcinoma

Cited by 3 publications

References 65 publications

A New Prognostic Model Covering All Stages of Intrahepatic Cholangiocarcinoma

A New Prognostic Model Covering All Stages of Intrahepatic Cholangiocarcinoma

The Emerging Role of Tumor Microenvironmental Stimuli in Regulating Metabolic Rewiring of Liver Cancer Stem Cells

Twenty years of histochemistry in the third millennium, browsing the scientific literature

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