2002
DOI: 10.1523/jneurosci.22-20-09015.2002
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Different Mechanisms for Loss and Recovery of Binocularity in the Visual Cortex

Abstract: Diverse molecular mechanisms have been discovered that mediate the loss of responses to the deprived eye during monocular deprivation. cAMP/Ca 2ϩ response element-binding protein (CREB) function, in particular, is thought to be essential for ocular dominance plasticity during monocular deprivation. In contrast, we have very little information concerning the molecular mechanisms of recovery from the effects of monocular deprivation, even though this information is highly relevant for understanding cortical plas… Show more

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Cited by 27 publications
(17 citation statements)
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“…Furthermore, H-ras G12V expression is unique in accelerating both deprivation-induced plasticity and recovery from deprivation. Previous studies have shown that these two processes differ mechanistically, involving distinct cellular processes (8,30,31). H-ras is known to initiate signaling pathways leading to activation of distinct sets of effector molecules depending on cellular conditions (15), consistent with our finding that constitutive activation of H-ras affects plasticity both during MD and during recovery from deprivation.…”
Section: Discussion Acceleration Of Multiple Forms Of Visual Cortex Psupporting
confidence: 90%
“…Furthermore, H-ras G12V expression is unique in accelerating both deprivation-induced plasticity and recovery from deprivation. Previous studies have shown that these two processes differ mechanistically, involving distinct cellular processes (8,30,31). H-ras is known to initiate signaling pathways leading to activation of distinct sets of effector molecules depending on cellular conditions (15), consistent with our finding that constitutive activation of H-ras affects plasticity both during MD and during recovery from deprivation.…”
Section: Discussion Acceleration Of Multiple Forms Of Visual Cortex Psupporting
confidence: 90%
“…Although recovery from MD has been shown to rely in part on different mechanisms than the initial MD (8,42), its progression is not well understood. Here we show that recovery from MD can be equally rapid and robust as the effects of initial MD and that even a few hours of eye opening can substantially reverse the effects of a week-long MD in ferrets.…”
Section: Discussionmentioning
confidence: 99%
“…For example, in juveniles, the ocular dominance shift induced by brief monocular deprivation is rapidly reversed if the occlusion is removed early in postnatal development 25-27 . In contrast, chronic monocular deprivation, from eye opening to adulthood, induces a significant shift in ocular dominance that does not reverse spontaneously following removal of the occlusion.…”
Section: Introductionmentioning
confidence: 99%