Purpose: the aim of the present research was to present an aggression prediction model in teenagers based on family cohesion and communication patterns with the mediating role of resilience. Methodology: this cross-sectional study was of correlation type. The research population consisted of second grade high school students of Tehran city in academic year 2019-2020. The research sample consisted of 500 individuals chosen through multistage cluster sampling method. They responded to the following instruments: Novaco Anger Scale and Provocation (Novaco, 1986), communication patterns (Ritchie and Fitz Patrick, 1990), family cohesion (Olson et al., 1985), and resilience (Connor and Davidson, 2003). The data were analyzed by Pearson correlation coefficient and structural equations modeling in SPSS and AMOS 22. Findings: the results showed that the aggression prediction model in teenagers based on family cohesion and communication patterns with the mediating role of resilience had good fit. Further, conformityoriented communication pattern did not have a direct significant effect on resilience and aggression in teenagers and indirect significant effect with the mediating role of resilience on aggression in them (P>0.05). However, the conversation-oriented communication pattern and family cohesion had a direct significant effect on resilience and aggression in teenagers as well as indirect significant effect with the mediating role of resilience on aggression in them (P<0.05). Conclusion: according to the obtained results, for reducing aggression in teenagers, the extent of conversation communication pattern and family cohesion can be promoted in them through organizing educational workshops.