Different Mice Strains in Biomarker Responses to Toxic Agents: The Example of Acetaminophen

Bavia, Lorena; Guiloski, Izonete Cristina; Carneiro, Milena Carvalho; Prodocimo, Maritana Mela

doi:10.1007/978-3-031-07392-2_78

Biomarkers in Disease: Methods, Discoveries and Applications

2023

DOI: 10.1007/978-3-031-07392-2_78

|View full text |Cite

Different Mice Strains in Biomarker Responses to Toxic Agents: The Example of Acetaminophen

Lorena Bavia

Izonete Cristina Guiloski²,

Milena Carvalho Carneiro

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Hepatoprotective Effect of Xymedon and its Conjugate with L-ascorbic Acid during Poisoning of Mice with a Semilethal Dose of Paracetamol

Belyaev,

Vyshtakalyuk,

Parfenov

et al. 2024

BMCRM

View full text Add to dashboard Cite

There is currently an urgent need to develop effective therapies aimed at preventing the consequences of drug-induced liver injury (DILI). In this context, our study focused on assessing the hepatoprotective effect of pyrimidine derivatives of xymedon (1,2-dihydro-4,6-dimethyl-1-(2- hydroxyethyl)-pyrimidin-2-one) and its conjugate with L-ascorbic acid in a mouse model of paracetamol (acetaminophen) poisoning. ICR (CD-1) mice were treated with a single oral LD50 dose of paracetamol (425 mg/kg), followed by intraperitoneal injections of various doses of the test compounds at various doses half an hour later. The animals` survival was monitored for 5 days. On the day 6, biochemical and histopathological evaluations of the effects of the test compounds were conducted. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were analyzed. Malondialdehyde (MDA) levels in blood and liver tissue were also determined. Xymedon attenuated the toxic effects of paracetamol on the liver, improving animal survival and enhancing the macro- and micro-structure of the liver, normalizing the biochemical indicator of liver condition ALT and the serum marker of oxidative stress MDA. The conjugate of xymedon with L-ascorbic acid exhibited a more pronounced hepatoprotective effect compared to the native xymedon molecule.

show abstract

Hepatoprotective Effect of Xymedon and its Conjugate with L-ascorbic Acid during Poisoning of Mice with a Semilethal Dose of Paracetamol

Belyaev,

Vyshtakalyuk,

Parfenov

et al. 2024

BMCRM

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Different Mice Strains in Biomarker Responses to Toxic Agents: The Example of Acetaminophen

Cited by 1 publication

References 54 publications

Hepatoprotective Effect of Xymedon and its Conjugate with L-ascorbic Acid during Poisoning of Mice with a Semilethal Dose of Paracetamol

Hepatoprotective Effect of Xymedon and its Conjugate with L-ascorbic Acid during Poisoning of Mice with a Semilethal Dose of Paracetamol

Contact Info

Product

Resources

About