Different Modes of Visual Integration in the Lateral Geniculate Nucleus Revealed by Single-Cell-Initiated Transsynaptic Tracing

Rompani, Santiago B.; Müllner, Fiona E.; Wanner, Adrian; Zhang, Chi; Roth, Chiara N.; Yonehara, Keisuke; Roska, Botond

doi:10.1016/j.neuron.2017.03.009

Cited by 33 publications

(44 citation statements)

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“…Our result that binocular dLGN afferents exhibited much stronger visual responses compared to monocular dLGN inputs is in agreement with a previous finding demonstrating that binocular dLGN cells receive inputs from a larger number of retinal ganglion cells compared to monocular cells (Rompani et al, 2017). It is currently unknown the mechanisms involved in the development of binocularity and interocular matching of SF and orientation tuning properties in dLGN neurons.…”

Section: Discussionsupporting

confidence: 93%

“…A growing body of recent evidence indicates that significant binocular processing occurs in dLGN in mice (Howarth et al, 2014;Jaepel et al, 2017;Sommeijer et al, 2017) and marmosets (Zeater et al, 2015). A retrograde tracing study (Rompani et al, 2017) demonstrated that single dLGN neurons receive direct retinal inputs from both eyes, providing an anatomical substrate for binocular integration in the mouse dLGN. A functional study (Jaepel et al, 2017) showed that ocular dominance of thalamic axons in V1 can be altered by short-term (6-8 days) MD under plasticity-enhancing conditions in adult mice but the effect was found to be transient.…”

Section: Introductionmentioning

confidence: 99%

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Critical-Period Visual Deprivation Disrupts Binocular Integration but Spares Spatial Acuity in the Geniculocortical Pathway

Huh¹,

Abdelaal²,

Salinas³

et al. 2018

Preprint

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1 SUMMARY Developing neural circuits are particularly vulnerable to alterations in early sensory experience. For example, monocular deprivation (MD) during a juvenile critical period leads to long-lasting changes in binocularity and spatial acuity of the visual system. The locus of these changes has been widely considered to be cortical. However, recent evidence indicates that binocular integration occurs first in the dorsolateral geniculate nucleus of the thalamus (dLGN) and that dLGN binocularity may be susceptible to changes in visual experience. This leaves open the question of whether MD during the critical period leads to long-lasting deficits in dLGN binocular integration. Using in vivo two-photon Ca 2+ imaging of dLGN afferents and excitatory neurons in superficial layers of binocular V1, we demonstrate that critical-period MD leads to a persistent and selective loss of binocular dLGN inputs, while leaving visual acuity in the thalamocortical pathway intact. Moreover, we found profound mismatch of preferred spatial frequency and orientation detected at the level of individual thalamocortical synapses. In V1 neurons, we found significant reductions in binocularity and visual acuity following critical-period MD. Our data suggest that alterations in cortical ocular dominance and binocular matching following critical-period MD may partially reflect a dysfunction of binocular integration in dLGN neurons.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Critical-Period Visual Deprivation Disrupts Binocular Integration but Spares Spatial Acuity in the Geniculocortical Pathway

Huh¹,

Abdelaal²,

Salinas³

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…Thus, we cannot safely conclude on the number of inhibitory inputs received by a single LSO neuron based on the present SBEM data. A similar disagreement between the number of optogenetically stimulated synaptic inputs, and the number of inputs found in connectomics studies on the light and electron microscopic level (Morgan et al 2016;Rompani et al 2017), has recently been found at the retinogeniculate synapse (Litvina & Chen, 2017).…”

Section: Technical Considerationsmentioning

confidence: 54%

Ultrastructural basis of strong unitary inhibition in a binaural neuron

Gjoni

Aguet

Sahlender

et al. 2018

The Journal of Physiology

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Binaural neurons in the lateral superior olive (LSO) integrate sound information arriving from each ear, and powerful glycinergic inhibition of these neurons plays an important role in this process. In the present study, we investigated the ultrastructural basis for strong inhibitory inputs onto LSO neurons using serial block face scanning electron microscopy. We reconstructed axon segments that make contact with the partially reconstructed soma and proximal dendrite of a mouse LSO neuron at postnatal day 18. Using functional measurements and the Sr method, we find a constant quantal size but a variable quantal content between 'weak' and 'strong' unitary IPSCs. A 3-D reconstruction of a LSO neuron and its somatic synaptic afferents reveals how a large number of inhibitory axons intermingle in a complex fashion on the soma and proximal dendrite of an LSO neuron; a smaller number of excitatory axons was also observed. A given inhibitory axon typically contacts an LSO neuron via several large varicosities (average diameter 3.7 μm), which contain several active zones (range 1-11). The number of active zones across individual axon segments was highly variable. These data suggest that the variable unitary IPSC amplitude is caused by a variable number of active zones between inhibitory axons that innervate a given LSO neuron. The results of the present study show that relatively large multi-active zone varicosities, which can be repeated many times in a given presynaptic axon, provide the ultrastructural basis for the strong multiquantal inhibition received by LSO neurons.

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“…Thus, our results suggest that post-retinal areas may need to differentially process cell type inputs. Recent work elucidating LGN processing of RGC output confirm that some LGN neurons receive predominant input from a single type of RGC (Rompani et al, 2017;Liang et al, 2018;Roman Roson et al, 2019). These studies also find LGN neurons with input from diverse types of RGCs, posing further questions of how correlations between RGCs of different types may affect early visual processing.…”

Section: Implications For Downstream Processingmentioning

confidence: 87%

Ignoring correlated activity causes a failure of retinal population codes under moonlight conditions

Ruda

Zylberberg

Field

2019

Preprint

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The retina encodes visual stimuli across light intensities spanning 10-12 orders of magnitude from starlight to sunlight. To accommodate this enormous range, adaptation alters retinal output, changing both the signal and noise among populations of retinal ganglion cells (RGCs). Here we determine how these light level-dependent changes in signal and noise impact decoding of retinal output. In particular, we consider the importance of accounting for noise correlations among RGCs to optimally read out retinal activity. We find that at moonlight conditions, correlated noise is greater and assuming independent noise severely diminished decoding performance. In fact, assuming independence among a local population of RGCs produced worse decoding than using a single RGC, demonstrating a failure of population codes when correlated noise is substantial and ignored. We generalize these results with a simple model to determine the signal and noise conditions under which this failure of population processing can occur. This work elucidates the circumstances in which accounting for noise correlations is necessary to take advantage of population-level codes and shows that sensory adaptation can strongly impact decoding requirements on downstream brain areas.

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Different Modes of Visual Integration in the Lateral Geniculate Nucleus Revealed by Single-Cell-Initiated Transsynaptic Tracing

Cited by 33 publications

References 0 publications

Critical-Period Visual Deprivation Disrupts Binocular Integration but Spares Spatial Acuity in the Geniculocortical Pathway

Critical-Period Visual Deprivation Disrupts Binocular Integration but Spares Spatial Acuity in the Geniculocortical Pathway

Ultrastructural basis of strong unitary inhibition in a binaural neuron

Ignoring correlated activity causes a failure of retinal population codes under moonlight conditions

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