Different neuronal and glial cell groups in corticomedial amygdala react differently to neonatally administered estrogen

Drekić, Dmitar; Malobabić, Slobodan; Gledić, D.; Cvetković, Dijana

doi:10.1016/0306-4522(94)00581-o

Cited by 13 publications

(7 citation statements)

References 28 publications

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“…Regional differences in GFAP expression and transcription and in the reactivity of both neurons and glia to estrogen have also been found by other authors [10, 11, 49]. This difference could be due to an indirect effect on the neighboring neurons.…”

Section: Discussionsupporting

confidence: 50%

Diurnal Oscillation in Glial Fibrillary Acidic Protein in a Perisuprachiasmatic Area and Its Relationship to the Luteinizing Hormone Surge in the Female Rat

Fernandez-Galaz

Muñoz²,

Villanúa³

et al. 1999

Neuroendocrinology

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It is well known that the reproductive cycle in the female rat is closely associated with the circadian rhythms of motor activity and that this phenomenon requires the presence of estrogens. Estrogens induce plastic changes in neural connectivity and these changes could be the result of glial modifications. We have measured glial fibrillary acidic protein (GFAP) immunoreactivity in order to localize the area in which the coupling of the circadian rhythms to the generation of the luteinizing hormone (LH) surge may occur. As circadian rhythms are driven by the suprachiasmatic nucleus (SCN), GFAP immunoreactivity was measured in 5 areas of the SCN and surrounding regions. It was measured at two times during daylight (10.00 and 17.00 h) in ovariectomized (OVX) females implanted with Silastic capsules containing either estradiol benzoate (EB) or oil (control). Differences between morning and afternoon GFAP immunoreactivity were observed in a peri-SCN area, dorsal to the SCN and close to the 3rd ventricle, in estrogen-treated as well as in control OVX females. However, this difference increased in the subgroup of EB-treated females which displayed the strongest LH rhythmicity. These results suggest that the peri-SCN area could be an important locus for synaptic changes linking circadian rhythms with the estrogen-induced LH surge.

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Section: Discussionsupporting

confidence: 50%

Diurnal Oscillation in Glial Fibrillary Acidic Protein in a Perisuprachiasmatic Area and Its Relationship to the Luteinizing Hormone Surge in the Female Rat

Fernandez-Galaz

Muñoz²,

Villanúa³

et al. 1999

Neuroendocrinology

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“…For example, synthetic androgens increase proliferation of astrocytes derived from human optic nerve head (Agapova et al, 2006), and dihydrotestosterone (DHT) protects primary cortical astrocytes from cell death due to metabolic and oxidative insults (Gatson and Singh, 2007). In the rodent amygdala in particular, evidence suggests that gonadal hormones can influence glial proliferation during early development and puberty (Dmitar et al, 1995; Drekić et al, 1995; Ahmed et al, 2008). During puberty, cells proliferate in the rat medial amygdala, with more new cells added in males than in females; many of these newly generated cells are astrocytes.…”

Section: Discussionmentioning

confidence: 99%

Astrocytes in the rat medial amygdala are responsive to adult androgens

Johnson

Schneider

DonCarlos

et al. 2012

J of Comparative Neurology

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The posterodorsal medial amygdala (MePD) exhibits numerous sex differences including differences in volume and in the number and morphology of neurons and astroctyes. In adulthood, gonadal hormones, including both androgens and estrogens, have been shown to play a role in maintaining the masculine character of many of these sex differences, but whether adult gonadal hormones maintain the increased number and complexity of astrocytes in the male MePD was unknown. To answer this question we examined astrocytes in the MePD of male and female Long Evans rats that were gonadectomized as adults and treated for 30 days with either testosterone or a control treatment. At the end of treatment brains were collected and immunostained for glial fibrillary acidic protein. Stereological analysis revealed that adult androgen levels influenced the number and complexity of astrocytes in the MePD of both sexes, but the specific effects of androgens were different in males and females. However, sex differences in the number and complexity of adult astrocytes persisted even in the absence of gonadal hormones in adulthood, suggesting that androgens also act earlier in life to determine these adult sex differences. Using immunofluorescence and confocal microscopy, we found robust androgen receptor immunostaining in a subpopulation of MePD astrocytes, suggesting that testosterone may act directly on MePD astrocytes to influence their structure and function.

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“…For example, synthetic androgens increase proliferation of astrocytes derived from human optic nerve head (Agapova et al,2006), and dihydrotestosterone (DHT) protects primary cortical astrocytes from cell death due to metabolic and oxidative insults (Gatson and Singh,2007). In the rodent amygdala in particular, evidence suggests that gonadal hormones can influence glial proliferation during early development and puberty (Dmitar et al,1995; Drekić et al,1995; Ahmed et al,2008). During puberty, cells proliferate in the rat medial amygdala, with more new cells added in males than in females; many of these newly generated cells are astrocytes.…”

Section: Discussionmentioning

confidence: 99%

Emerging issues in smoking among adolescent and adult cancer survivors

Klosky

Tyc

Garces-Webb

et al. 2007

Cancer

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The number of cancer survivors is significantly increasing, thereby prioritizing the importance of identifying and preventing adverse health outcomes within this high-risk population. Cigarette smoking is of particular salience as it places both adolescents and adults with a cancer history at risk for various health problems, including second malignancies. The purpose of this article is to provide a comprehensive review of the smoking literature as it relates to adolescents and adults on-treatment and surviving cancer. In particular, the article reviews the prevalence, risk factors, and health outcomes associated with smoking, in addition to the prevention and smoking cessation interventions available to adolescent and adult oncology patients. Furthermore, efficacious cessation strategies have recently emerged from the smoking literature in healthy populations, and their application to oncology populations is discussed.

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Different neuronal and glial cell groups in corticomedial amygdala react differently to neonatally administered estrogen

Cited by 13 publications

References 28 publications

Diurnal Oscillation in Glial Fibrillary Acidic Protein in a Perisuprachiasmatic Area and Its Relationship to the Luteinizing Hormone Surge in the Female Rat

Diurnal Oscillation in Glial Fibrillary Acidic Protein in a Perisuprachiasmatic Area and Its Relationship to the Luteinizing Hormone Surge in the Female Rat

Astrocytes in the rat medial amygdala are responsive to adult androgens

Emerging issues in smoking among adolescent and adult cancer survivors

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