Different Perceptions and Attitudes regarding Prenatal Testing among Service Providers and Consumers in Israel

Dery, Anat Mishori; Carmi, Rivka; Shoham‐Vardi, Ilana

doi:10.1159/000106563

Cited by 6 publications

(1 citation statement)

References 57 publications

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“…On the basis of the high uptake of prenatal genetic screening by the AJ population in Israel - even for conditions that do not meet screening criteria (such as hearing loss and Gaucher disease) [45,46,47] - it can be assumed that Israel will be one of the first countries to implement BRCA population screening of the AJ population.…”

Section: Discussionmentioning

confidence: 99%

Clinicians' Attitudes toward General Screening of the Ashkenazi-Jewish Population for Prevalent Founder BRCA1/2 and LRRK2 Mutations

Shkedi‐Rafid

Ofer-Bialer

Meiner³

et al. 2013

Public Health Genomics

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Aims: Advances in genomics may eventually lead to genetic susceptibility screening of the general population, regardless of a personal or familial history of the disease in question. Yet, little is known about clinicians' attitudes toward such programs. We explored attitudes of family practitioners, medical geneticists and genetic counselors toward genetic screening of the general Ashkenazi-Jewish population for the common founder mutations in BRCA1/2 and LRRK2 genes (which increase the risk of hereditary breast/ovarian cancers and Parkinson's disease, respectively). Methods: Participants (n = 204) completed a specially designed questionnaire, distributed by e-mail, regular mail or in-person. Results: Slightly more than half (52%) were in favor of BRCA screening, while the vast majority (86%) opposed to LRRK2 screening. About two-thirds (68%) of the respondents supported pre-test genetic counseling. Attitudes were largely independent of professional background and sociodemographic characteristics, though a correlation was found with personal interest in genetic self-testing for the above genes. Adverse psychological impact and discrimination in insurance and employment were the major concerns cited by respondents with regard to screening programs. Conclusion: Our findings suggest that the availability of measures for prevention and/or treatment is a major factor in the attitudes of healthcare providers toward population screening for late-onset conditions.

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Section: Discussionmentioning

confidence: 99%

Clinicians' Attitudes toward General Screening of the Ashkenazi-Jewish Population for Prevalent Founder BRCA1/2 and LRRK2 Mutations

Shkedi‐Rafid

Ofer-Bialer

Meiner³

et al. 2013

Public Health Genomics

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Attitudes toward the acceptability of reasons for pregnancy termination due to fetal abnormalities among prenatal care providers and consumers in Israel

Dery¹,

Carmi²,

Vardi³

2008

Prenatal Diagnosis

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BRCA genetic testing of individuals from families with low prevalence of cancer: experiences of carriers and implications for population screening

Shkedi‐Rafid

Gabai-Kapara

Grinshpun‐Cohen

et al. 2012

Genetics in Medicine

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Purpose: BRCA genes are associated with hereditary breast and ovarian cancers. Guidelines worldwide currently recommend BRCA genetic testing in asymptomatic individuals only if they belong to "high-risk" families. However, population screening for BRCA1/2 may be the logical next step in populations with a high prevalence of founder mutations, such as Ashkenazi Jews. This study aimed to explore (i) the impact of a positive BRCA genetic test result on individuals who have neither a personal history nor a familial history of cancer and (ii) their attitudes toward the concept of population screening.methods: Semistructured in-depth interviews were carried out with 14 Ashkenazi Jewish women who were asymptomatic BRCA carriers and who belonged to families with low prevalence of cancer.Results: Three main findings emerged: (i) having no family history of cancer was a source of optimism but also confusion; (ii) engaging in intensified medical surveillance and undergoing preventive procedures was perceived as health-promoting but also tended to induce a sense of physical and psychological vulnerability; and (iii) there was overall support for BRCA population screening, with some reservations.conclusion: Women belonging to low-cancer-prevalence families within a "high-risk" ethnic community view BRCA genetic testing positively despite the difficulties entailed, because it allows prevention or early detection of cancer. However, implementing a BRCA population screening program should be carried out with proper pre-and post-testing preparation and support for the individuals undergoing testing.Genet Med 2012:14(7):688-694

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Different Perceptions and Attitudes regarding Prenatal Testing among Service Providers and Consumers in Israel

Cited by 6 publications

References 57 publications

Clinicians' Attitudes toward General Screening of the Ashkenazi-Jewish Population for Prevalent Founder <b><i>BRCA1/2</i></b> and <b><i>LRRK2</i></b> Mutations

Clinicians' Attitudes toward General Screening of the Ashkenazi-Jewish Population for Prevalent Founder <b><i>BRCA1/2</i></b> and <b><i>LRRK2</i></b> Mutations

Attitudes toward the acceptability of reasons for pregnancy termination due to fetal abnormalities among prenatal care providers and consumers in Israel

BRCA genetic testing of individuals from families with low prevalence of cancer: experiences of carriers and implications for population screening

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