Different Periods of Periconceptional Undernutrition Have Different Effects on Growth, Metabolic and Endocrine Status in Fetal Sheep

Rumball, Christopher; Bloomfield, Frank H.; Oliver, Mark; Harding, Jane E.

doi:10.1203/pdr.0b013e3181bbde72

Cited by 41 publications

(33 citation statements)

References 33 publications

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“…Investigations in the field of DOHaD shift from size at birth to focusing on the timing of malnutrition during pregnancy. An increasing body of evidence from experimental animal studies indicates that the timing of malnutrition during and even before gestation has a profound effect on adult health while not resulting in a low birth weight [26][27][28]. The Dutch hunger winter presented an exceptional situations in history to study the effect of malnutrition in different gestational periods [29].…”

Section: Discussionmentioning

confidence: 99%

Developmental origins of polycystic ovary syndrome (PCOS), a case control study comparing birth weight in women with PCOS and control group

Sadrzadeh

Painter

Lambalk

2016

Gynecological Endocrinology

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Evidence from various epidemiological studies and experimental animal studies has linked adverse intrauterine circumstances with health problems in adult life. This field of investigation is known as Developmental Origins of Health and Disease (DOHaD). Studies investigating the relation between developing polycystic ovary syndrome (PCOS) in adulthood and birth weight have yielded inconsistent results: PCOS is described more often in women with low birth weight and high birth weight, while other studies have failed to establish any relation. In this retrospective case-control study, we evaluated whether women diagnosed with PCOS had lower birth weight compared to women with a regular menstrual cycle (controls). Binary logistic regression models were used to analyze the data and correct for known confounders. About 65 women with PCOS and 96 controls were recruited for this purpose. The average birth weight of PCOS women (3357 g) did not differ from the average birth weight of controls (3409 g). Mean age at menarche differed significantly between groups, 13.7 years and 12.8 years (p ¼ 0.006), respectively, for PCOS women and controls. In conclusion, we could not confirm the effect of adverse intrauterine conditions, reflected in birth weight, on developing PCOS.

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Section: Discussionmentioning

confidence: 99%

Developmental origins of polycystic ovary syndrome (PCOS), a case control study comparing birth weight in women with PCOS and control group

Sadrzadeh

Painter

Lambalk

2016

Gynecological Endocrinology

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“…Within the laboratory, early life undernutrition can be achieved through maternal dietary restriction during pregnancy and/or lactation and in some cases during the periconceptional period [59,60] . At present, those investigating the mechanistic links between maternal undernutrition and adult disease generally utilize one of two dietary protocols in the rodent; global undernutrition or isocaloric low protein diets, with the maternal low protein (MLP) diet being the more extensively used [61][62][63][64][65] .…”

Section: Maternal Undernutritionmentioning

confidence: 99%

Developmental programming of the metabolic syndrome - critical windows for intervention

Vickers

2011

WJG

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Metabolic disease results from a complex interaction of many factors, including genetic, physiological, behavioral and environmental influences. The recent rate at which these diseases have increased suggests that environmental and behavioral influences, rather than genetic causes, are fuelling the present epidemic. In this context, the developmental origins of health and disease hypothesis has highlighted the link between the periconceptual, fetal and early infant phases of life and the subsequent development of adult obesity and the metabolic syndrome. Although the mechanisms are yet to be fully elucidated, this programming was generally considered an irreversible change in developmental trajectory. Recent work in animal models suggests that developmental programming of metabolic disorders is potentially reversible by nutritional or targeted therapeutic interventions during the period of developmental plasticity. This review will discuss critical windows of developmental plasticity and possible avenues to ameliorate the development of postnatal metabolic disorders following an adverse early life environment.

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“…pregnancy outcomes, independently of attained BMI [8,9]. Indeed, maternal weight change before pregnancy can be considered as an indicator of maternal energy balance and nutritional status before conception.…”

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confidence: 99%

Maternal weight change before pregnancy in relation to birthweight and risks of adverse pregnancy outcomes

et al. 2011

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Maternal weight change before pregnancy can be considered as an indicator of maternal energy balance and nutritional status before conception, and may be involved in early life programming. We aimed to investigate the association of maternal Weight Change Before Pregnancy (WCBP) with fetal growth and adverse pregnancy outcomes. Data are from the French EDEN mother-child cohort where 1,756 mother-child pairs had information on mother's weight at 20 years, weight just before pregnancy, fetal anthropometry at second and third trimesters, infant's birthweight and pregnancy complications. The average annual WCBP between 20 years and start of pregnancy (in kg/year) was categorized as: "Weight Loss" (n = 320), "Moderate weight gain" (n = 721) and "High weight gain" (n = 715). The associations of WCBP with fetal and newborn characteristics and with adverse pregnancy outcomes were analyzed, adjusting for maternal and pregnancy characteristics, including the mother's prepregnancy BMI. Interactions between WCBP and prepregnancy BMI were tested. Birthweight and estimated fetal weight in the third trimester increased significantly with increasing WCBP in mothers with BMI <25 kg/m(2). In these mothers, weight loss before pregnancy was associated with a higher risk of newborns small for gestational age (SGA). Whatever the prepregnancy BMI, WCBP was positively associated with a maternal risk of gestational diabetes and hypertension. The ponderal history of mothers before pregnancy can impact on fetal growth and on pregnancy outcomes such as gestational diabetes or hypertension. Our analysis is the first to report that in non-overweight women, those who lost weight before pregnancy are at higher risk of having SGA newborns.

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Different Periods of Periconceptional Undernutrition Have Different Effects on Growth, Metabolic and Endocrine Status in Fetal Sheep

Cited by 41 publications

References 33 publications

Developmental origins of polycystic ovary syndrome (PCOS), a case control study comparing birth weight in women with PCOS and control group

Developmental origins of polycystic ovary syndrome (PCOS), a case control study comparing birth weight in women with PCOS and control group

Developmental programming of the metabolic syndrome - critical windows for intervention

Maternal weight change before pregnancy in relation to birthweight and risks of adverse pregnancy outcomes

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