1998
DOI: 10.1016/s0014-2999(97)01495-7
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Different potencies of dihydropyridine derivatives in blocking T-type but not L-type Ca2+ channels in neuroblastoma-glioma hybrid cells

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Cited by 40 publications
(26 citation statements)
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“…Other reports have also shown a selective action on T-type Ca 2þ channels at this lower concentration [Sui et al, 2001b]. Verapamil also has been reported to have nonselective e¡ects, but again these are at higher concentrations than those used here [Stengel et al, 1998], its potency on detrusor contractility is similar to that reported by others [Zhao et al, 1993].…”
Section: Actions Of Nicl 2 and Verapamil On Detrusor Contractilitysupporting
confidence: 83%
“…Other reports have also shown a selective action on T-type Ca 2þ channels at this lower concentration [Sui et al, 2001b]. Verapamil also has been reported to have nonselective e¡ects, but again these are at higher concentrations than those used here [Stengel et al, 1998], its potency on detrusor contractility is similar to that reported by others [Zhao et al, 1993].…”
Section: Actions Of Nicl 2 and Verapamil On Detrusor Contractilitysupporting
confidence: 83%
“…In contrast, amlodipine inhibits bTREK-1 with an IC 50 value comparable with that of the DPBPs and mibefradil (Gomora and Enyeart, 1999a,b;Enyeart et al, 2002a). Although niguldipine is 50 to 100 times more potent than amlodipine at inhibiting T-type Ca 2ϩ channels in various cells, it was slightly less potent than amlodipine as an inhibitor of bTREK-1 (Romanin et al, 1992;Stengel et al, 1998;Heady et al, 2001). In bovine AZF cells, 20 M amlodipine inhibited T-type Ca 2ϩ channels by only 29.0%, indicating that it was approximately 100-fold more potent as an inhibitor of bTREK-1.…”
Section: Discussionmentioning
confidence: 98%
“…Evidence has accumulated that some classic L-type CCBs may also inhibit T-type calcium channels in neurons (Stengel et al, 1998). Flunarizine and diltiazem have been reported to block both L-type and T-type calcium channels in cultured smooth muscle cells although flunarizine was reported to be a more effective T-type blocker than diltiazem (Kuga et al, 1990).…”
Section: Discussionmentioning
confidence: 99%