Different Profile of Serum Leptin between Early Onset and Late Onset Preeclampsia

Salimi, Saeedeh; Farajian-Mashhadi, Farzaneh; Naghavi, Anoosh; Mokhtari, Mojgan; Sheikhi, Mahnaz; Saravani, Mohsen; Yaghmaei, Minoo

doi:10.1155/2014/628476

Cited by 40 publications

(28 citation statements)

References 42 publications

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“…There have been studies reporting that higher serum leptin is observed in preeclamptic patients compared to normal pregnancies [29,30]. In addition to this, serum LEP has been reported to be higher in early-onset PE compared to late-onset PE [31]. This, however, contrasts with others who did not find any correlation between leptin expression with PE [32].…”

Section: Discussionmentioning

confidence: 92%

A Review of Candidate Genes and Pathways in Preeclampsia–An Integrated Bioinformatical Analysis

Mohamad

Manzor

Zulkifli

et al. 2020

Biology

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Preeclampsia is a pregnancy-specific disorder characterized by the presence of hypertension with the onset of either proteinuria, maternal organ or uteroplacental dysfunction. Preeclampsia is one of the leading causes of maternal and fetal mortality and morbidity worldwide. However, the etiopathologies of preeclampsia are not fully understood. Many studies have indicated that genes are differentially expressed between normal and in the disease state. Hence, this study systematically searched the literature on human gene expression that was differentially expressed in preeclampsia. An electronic search was performed through 2019 through PubMed, Scopus, Ovid-Medline, and Gene Expression Omnibus where the following MeSH (Medical Subject Heading) terms were used and they had been specified as the primary focus of the articles: Gene, placenta, preeclampsia, and pregnancy in the title or abstract. We also found additional MeSH terms through Cochrane Library: Transcript, sequencing, and profiling. From 687 studies retrieved from the search, only original publications that had performed high throughput sequencing of human placental tissues that reported on differentially expressed genes in pregnancies with preeclampsia were included. Two reviewers independently scrutinized the titles and abstracts before examining the eligibility of studies that met the inclusion criteria. For each study, study design, sample size, sampling type, and method for gene analysis and gene were identified. The genes listed were further analyzed with the DAVID, STRING and Cytoscape MCODE. Three original research articles involving preeclampsia comprising the datasets in gene expression were included. By combining three studies together, 250 differentially expressed genes were produced at a significance setting of p < 0.05. We identified candidate genes: LEP, NRIP1, SASH1, and ZADHHC8P1. Through GO analysis, we found extracellular matrix organization as the highly significant enriched ontology in a group of upregulated genes and immune process in downregulated genes. Studies on a genetic level have the potential to provide new insights into the regulation and to widen the basis for identification of changes in the mechanism of preeclampsia. Integrated bioinformatics could identify differentially expressed genes which could be candidate genes and potential pathways in preeclampsia that may improve our understanding of the cause and underlying molecular mechanisms that could be used as potential biomarkers for risk stratification and treatment.

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Section: Discussionmentioning

confidence: 92%

A Review of Candidate Genes and Pathways in Preeclampsia–An Integrated Bioinformatical Analysis

Mohamad

Manzor

Zulkifli

et al. 2020

Biology

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“…Leptin is particularly well studied in the context of pregnancy. This hormone, produced by both adipocytes and the placenta, increases linearly throughout gestation, and abnormally elevated leptin levels have been consistently associated with pathologic pregnancies, including gestational diabetes mellitus and preeclampsia [36,157]. The leptin receptor is found on both innate and adaptive immune cells, and a variety of early observational in vitro studies have linked it with pathologic inflammation (such as that seen in autoimmune diseases and chronic obesity), differentiation of pro-inflammatory Th17 cells, and inhibition of the differentiation of Tregs [40,127,138].…”

Section: Metabolic Regulation Of Immune Responses In Pregnancymentioning

confidence: 99%

Multiomic immune clockworks of pregnancy

et al. 2020

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Preterm birth is the leading cause of mortality in children under the age of five worldwide. Despite major efforts, we still lack the ability to accurately predict and effectively prevent preterm birth. While multiple factors contribute to preterm labor, dysregulations of immunological adaptations required for the maintenance of a healthy pregnancy is at its pathophysiological core. Consequently, a precise understanding of these chronologically paced immune adaptations and of the biological pacemakers that synchronize the pregnancy "immune clock" is a critical first step towards identifying deviations that are hallmarks of peterm birth. Here, we will review key elements of the fetal, placental, and maternal pacemakers that program the immune clock of pregnancy. We will then emphasize multiomic studies that enable a more integrated view of pregnancy-related immune adaptations. Such multiomic assessments can strengthen the biological plausibility of immunological findings and increase the power of biological signatures predictive of preterm birth

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“…Preeclampsia is a heterogeneous disorder with two subtypes that have been described based on the timing of disease onset (early and late onset of preeclampsia), and several risk factors for preeclamptic development differed significantly in their association with early versus late onset (Rolfo et al, ; Aksornphusitaphong and Phupong, ; Lisonkova and Joseph, ; Salimi et al, ). We evaluated the mRNA and protein expression of PiT‐1 and PiT‐2 in preterm (early‐onset) or term (late‐onset) labor.…”

Section: Discussionmentioning

confidence: 99%

Comparing the expression patterns of placental magnesium/phosphorus‐transporting channels between healthy and preeclamptic pregnancies

Yang

Kim

Lee

et al. 2014

Molecular Reproduction Devel

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Preeclampsia is a pregnancy-specific disorder characterized by de novo development of concurrent hypertension, proteinuria, and placental oxidative stress. During the last trimester of gestation, maternal-to-fetal transport of minerals is dramatically increased and becomes tightly mediated by ion channels that are highly permeable to various divalent cations, such as Ca(2+) , Mg(2+) , and Zn(2+) . The regulation of magnesium/inorganic phosphorus ion-channel transport in the placenta, however, is not incompletely understood. In the present study, we examined the regulation of magnesium/inorganic phosphorus channels (MPCs) in the placenta of pregnant women suffering from preeclampsia as well as in primary human placental cells subjected to oxidative stress. The expression of MPC genes (TRPM6, TRPM7, PiT-1, and PiT-2) was down-regulated in preeclamptic placenta tissues during preterm labor, and generally remained lower at term labor-although TRPM7 expression in the central placenta or PiT-2 expression in whole placenta was unchanged or up-regulated. Consistent with this association, expression of MPC genes in the primary placental cells was reduced under hypoxic conditions. TRPM6, TRPM7, and PiT-1 channels were predominantly detected in the syncytiotrophoblast layers of the placenta. In contrast, PiT-2 was abundant in the placental intravillous connective tissues. Taken together, our findings indicated that placental MPC expression is down-regulated in cases of preeclampsia and under hypoxia. This relationship may contribute to a better understanding of the interrelationship between magnesium/inorganic phosphorus imbalances and preeclampsia development during preterm or term labor.

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Different Profile of Serum Leptin between Early Onset and Late Onset Preeclampsia

Cited by 40 publications

References 42 publications

A Review of Candidate Genes and Pathways in Preeclampsia–An Integrated Bioinformatical Analysis

A Review of Candidate Genes and Pathways in Preeclampsia–An Integrated Bioinformatical Analysis

Multiomic immune clockworks of pregnancy

Comparing the expression patterns of placental magnesium/phosphorus‐transporting channels between healthy and preeclamptic pregnancies

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