Different Proinflammatory Cytokine Serum Pattern in Neonate Patients Undergoing Open Heart Surgery. Relevance of IL-8

Romero, Andrés J. Alcaraz; Manzano, Luís; Sancho, Luís; Vigil, M. D.; Esquivel, F.; Maroto, Enrique E.; Reyes, Eduardo; Álvarez‐Mon, Melchor

doi:10.1007/s10875-005-4081-7

Cited by 31 publications

(21 citation statements)

References 33 publications

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“…There would likely be an IL-8 concentration gradient between blood and inflamed local tissue, so neutrophils could be chemo-attracted to inflammatory sites. In contrast, surgical cardiac stress elicits an increase in IL-8 serum concentration (Alcaraz et al, 2005). In conclusion, BAND, BURD, and CORT did not induce leukocytosis, whereas BURD induced a modest neutrophilia; neutrophil functioning in terms of phagocytosis and respiratory burst and serum IL-8 concentration were not compromised by BAND, BURD, or CORT.…”

Section: Discussionmentioning

confidence: 69%

Effects of banding or burdizzo castration of bulls on neutrophil phagocytosis and respiratory burst, CD62-L expression, and serum interleukin-8 concentration

Pang

Earley

Sweeney

et al. 2009

Journal of Animal Science

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The objective was to investigate measures of neutrophil function in response to banding or burdizzo castration of bulls. Thirty-two Holstein-Friesian bulls (14 mo old, 505 +/- 7.8 kg of BW) were assigned to 1 of 4 treatment groups: 1) sham-handled control (CON); 2) banding castration alone (BAND); 3) burdizzo castration alone (BURD); or 4) cortisol infusion (CORT) as a further control group. For each group on d -14, 8 animals (2 animals/treatment) were tied up in tie stalls (day of treatment = d 0). At -2, 2, 6, 12, 24, 48, 72, and 144 h relative to treatment time, blood samples were collected for analyses of neutrophil phagocytosis and respiratory burst, neutrophil CD62-L expression, and serum IL-8 concentration. Leukocyte counts, phagocytosis activity, and CD62-L expression were similar (P > 0.05) among the 4 treatment groups. The BURD castrates had greater burst activity compared with BAND castrates (P = 0.048) and CON (P = 0.01) at 72 h posttreatment. The BURD castrates had a greater percentage of granulocyte positive leukocytes (Gr%; P < 0.01) at 2 h posttreatment compared with CON and CORT bulls. The BURD castrates had greater (P < 0.05) Gr% compared with BAND, CON, and CORT animals at 24, 48, and 72 h posttreatment. The BURD and BAND castrates had greater Gr% (P < 0.05) compared with CORT bulls at 144 h posttreatment. In general, BAND, BURD, and CORT did not affect serum IL-8 concentration. Banding castration, BURD, and CORT did not induce leukocytosis, whereas BURD induced a modest neutrophilia. Neutrophil functioning in terms of phagocytosis and respiratory burst and serum IL-8 concentration were not compromised by BAND, BURD, and CORT. These findings indicate nonsurgical castration is unlikely to induce a severe acute systemic inflammatory response in terms of neutrophil function.

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Section: Discussionmentioning

confidence: 69%

Effects of banding or burdizzo castration of bulls on neutrophil phagocytosis and respiratory burst, CD62-L expression, and serum interleukin-8 concentration

Pang

Earley

Sweeney

et al. 2009

Journal of Animal Science

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“…al. 6 investigated 8 neonates and 19 infants undergoing CPB and demonstrated significant increases in IL-6, IL-8 and TNF in both groups postoperatively. The magnitude of the inflammatory response was greater in the neonates, particularly for IL-8.…”

Section: Discussionmentioning

confidence: 99%

“…The SIRS is further exacerbated in neonates due to morbidity factors of smaller patient size, greater hemodilution, hypothermia, and longer CPB times, resulting in a postoperative recovery period that is longer and more complex than similar operations performed in older infants and children. 4-6 …”

Section: Introductionmentioning

confidence: 99%

Preoperative steroid treatment does not improve markers of inflammation after cardiac surgery in neonates: Results from a randomized trial

Graham

Atz

McHugh

et al. 2014

The Journal of Thoracic and Cardiovascular Surgery

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Objective Neonatal cardiac surgery requiring cardiopulmonary bypass results in a heightened inflammatory response. Perioperative glucocorticoid administration is commonly utilized in attempt to reduce the inflammatory cascade, although characterization of the cytokine response to steroids in neonatal cardiac surgery remains elusive due to highly variable approaches in administration. This randomized trial was designed to prospectively evaluate the effect of specific glucocorticoid dosing protocols on inflammatory markers in neonatal cardiac surgery requiring cardiopulmonary bypass. Methods Neonates scheduled for cardiac surgery were randomly assigned to receive either two-dose (8 hours preoperatively and operatively, n=36) or single dose (operatively, n=32) methylprednisolone at 30mg/kg/dose in a prospective double-blind trial. The primary outcome was the effect of these steroid regimens on markers of inflammation. Secondary analyses evaluated the association of specific cytokine profiles with postoperative clinical outcomes. Results Patient demographics, perioperative variables and preoperative indices of inflammation were similar between the single and two-dose groups. Preoperative cytokine response after the two-dose methylprednisolone protocol was consistent with an anti-inflammatory effect, although this did not persist into the postoperative period. Pre-medication baseline levels of interleukin-6, interleukin-8, interleukin-10 and tumor necrosis factor alpha were predictive of postoperative intensive care unit and hospital length of stay. Only interleukin-8 demonstrated a postoperative response associated with duration of intensive care unit and hospital stay. Conclusions The addition of a preoperative dose of methylprednisolone to a standard intraoperative methylprednisolone dose does not improve markers of inflammation following neonatal cardiac surgery. The routine administration of preoperative glucocorticoids in neonatal cardiac surgery should be reconsidered. This is the largest pediatric and only exclusively neonatal randomized trial examining the anti-inflammatory effect of two different methylprednisolone dosing regimens for neonates requiring cardiac surgery. The addition of a preoperative dose of methylprednisolone to a standard intraoperative methylprednisolone dose does not improve markers of inflammation following neonatal cardiac surgery.

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“…Neonatal CPB is associated with increased plasma concentration of pro-inflammatory cytokines, which have been shown to correlate with deleterious clinical outcomes [17–18]. Patients with low IgG had increased plasma concentrations of the pro-inflammatory cytokines IL-6, IL-8 and IL-12, hypoalbuminemia, and increased fluid overload consistent with SIRS [19].…”

Section: Discussionmentioning

confidence: 99%

Hypogammaglobulinemia after cardiopulmonary bypass in infants

Rhodes

Robert

Atkinson

et al. 2014

The Journal of Thoracic and Cardiovascular Surgery

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Background Hypogammaglobulinemia has been reported after cardiac surgery and may be associated with adverse outcomes. We sought to define baseline immunoglobulin (Ig) concentration in neonates and infants with congenital heart disease, determine its course following cardiopulmonary bypass (CPB), and determine if post-CPB hypogammaglobulinemia was associated with increased morbidity. Methods Single center, retrospective analysis of infants who underwent cardiac surgery with CPB between June 2010 and December 2011. Ig concentration obtained from banked plasma of 47 patients from a prior study (pre-CPB, immediately post-CPB, and 24- and 48-hours post-CPB). Additionally, any Ig levels drawn for clinical purposes after CPB were included. Ig levels were excluded if drawn after chylothorax diagnosis or intravenous immunoglobulin G administration. Results Median age was 7 days. Preoperative Ig concentration was similar to that described in healthy children. IgG level fell to less than 50% of preoperative concentration by 24-hr post-CPB and failed to recover by 7 days. 25/47 (53%) patients had low IgG after CPB (<248 mg/dl). Despite no difference in demographics or risk factors between patients with low and normal IgG, low IgG patients had more positive fluid balance at 24-hours, increased pro-inflammatory plasma cytokine levels, duration of mechanical ventilation, and CICU length of stay. Additionally, low IgG patients had increased incidence of post-operative infections (40% vs. 14%, p=0.056). Conclusions Hypogammaglobulinemia occurs in half of infants after CPB. Its association with fluid overload and increased inflammatory cytokines suggests it may result from capillary leak. Postoperative hypogammaglobulinemia is associated with increased morbidity, including more secondary infections.

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Different Proinflammatory Cytokine Serum Pattern in Neonate Patients Undergoing Open Heart Surgery. Relevance of IL-8

Cited by 31 publications

References 33 publications

Effects of banding or burdizzo castration of bulls on neutrophil phagocytosis and respiratory burst, CD62-L expression, and serum interleukin-8 concentration

Effects of banding or burdizzo castration of bulls on neutrophil phagocytosis and respiratory burst, CD62-L expression, and serum interleukin-8 concentration

Preoperative steroid treatment does not improve markers of inflammation after cardiac surgery in neonates: Results from a randomized trial

Hypogammaglobulinemia after cardiopulmonary bypass in infants

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