Different rates of conjunctivitis in COVID-19 eastern and western hospitalized patients: a meta-analysis

Loffredo, Lorenzo; Fallarino, Alessia; Paraninfi, Aurora; Pacella, Fernanda; Pacella, Elena; Oliva, Alessandra; Violi, Francesco

doi:10.1007/s11739-021-02880-z

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…Although reported rates of ocular symptoms have varied, a recent meta-analysis by Inomata et al reported that 11.2% of coronavirus disease 2019 (COVID-19) patients experienced some form of ocular manifestation [ 5 ]. Another meta-analysis of COVID-19 patients by Loffredo and colleagues reported the frequency of conjunctivitis, the most commonly described ocular manifestation of SARS-CoV-2 infection, as 5.9% [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Ocular symptoms in COVID-19 infection: a survey study

McHarg

Wang

Yakin

et al. 2022

J Ophthal Inflamm Infect

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Background Coronavirus disease 2019 (COVID-19) systemic symptoms and sequelae have been studied extensively, but less is known about the characterization, duration, and long-term sequelae of ocular symptoms associated with COVID-19 infection. The purpose of this study was to analyze the frequency, spectrum, and duration of ocular symptoms in participants with COVID-19 infection treated in inpatient and outpatient settings. Methods A retrospective electronic survey was distributed to NIH employees and the public who reported testing positive for SARS-CoV-2. The anonymous survey collected information on demographics, past ocular history, systemic COVID-19 symptoms, and ocular symptoms. Results A total of 229 (21.9% male and 78.1% female, mean age 42.5 ± 13.9) survey responses were included. Ocular symptoms were reported by 165 participants with a mean of 2.31 ± 2.42 symptoms. The most commonly reported ocular symptoms were light sensitivity (31.0%), itchy eyes (24.9%), tearing (24.9%), eye redness (24.5%), and eye pain (24.5%). Participants with ocular symptoms had a higher number of systemic symptoms compared to participants without ocular symptoms (mean 9.17 ± 4.19 vs 6.22 ± 3.63; OR: 1.21; 95% CI: 1.11 – 1.32; p < 0.001). Ocular symptoms were more common in those who reported a past ocular history compared to those who did not (81.8% vs 67.1%; OR: 2.17; 95% CI: 1.08 – 4.37; p = 0.03). Additionally, the onset of ocular symptoms occurred most frequently at the same time as systemic symptoms (47.5%), and 21.8% reported symptoms lasting ≥ 14 days. Conclusions Ocular surface-related symptoms are the most frequent ocular manifestations, and systemic disease severity is associated with the presence of ocular symptoms. Additionally, our results show that ocular symptoms can persist post-COVID-19 infection. Further work is needed to better understand ocular symptoms in COVID-19 and long-term sequelae.

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Section: Introductionmentioning

confidence: 99%

Ocular symptoms in COVID-19 infection: a survey study

McHarg

Wang

Yakin

et al. 2022

J Ophthal Inflamm Infect

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I’ve looked at gut from both sides now: Gastrointestinal tract involvement in the pathogenesis of SARS-CoV-2 and HIV/SIV infections

Pandrea

Brooks²,

Desai³

et al. 2022

Front. Immunol.

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The lumen of the gastrointestinal (GI) tract contains an incredibly diverse and extensive collection of microorganisms that can directly stimulate the immune system. There are significant data to demonstrate that the spatial localization of the microbiome can impact viral disease pathogenesis. Here we discuss recent studies that have investigated causes and consequences of GI tract pathologies in HIV, SIV, and SARS-CoV-2 infections with HIV and SIV initiating GI pathology from the basal side and SARS-CoV-2 from the luminal side. Both these infections result in alterations of the intestinal barrier, leading to microbial translocation, persistent inflammation, and T-cell immune activation. GI tract damage is one of the major contributors to multisystem inflammatory syndrome in SARS-CoV-2-infected individuals and to the incomplete immune restoration in HIV-infected subjects, even in those with robust viral control with antiretroviral therapy. While the causes of GI tract pathologies differ between these virus families, therapeutic interventions to reduce microbial translocation-induced inflammation and improve the integrity of the GI tract may improve the prognoses of infected individuals.

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Incidence of acute infectious conjunctivitis across the pre- and post-COVID era: a 7-year-result from a tertiary acute hospital in Hong Kong

2024

Journal of Acute Disease

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Different rates of conjunctivitis in COVID-19 eastern and western hospitalized patients: a meta-analysis

Cited by 3 publications

References 16 publications

Ocular symptoms in COVID-19 infection: a survey study

Ocular symptoms in COVID-19 infection: a survey study

I’ve looked at gut from both sides now: Gastrointestinal tract involvement in the pathogenesis of SARS-CoV-2 and HIV/SIV infections

Incidence of acute infectious conjunctivitis across the pre- and post-COVID era: a 7-year-result from a tertiary acute hospital in Hong Kong

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