Different Responses of Two Mouse Strains to 650 Rads and Protection by Surgical Stress

The Forms, Uses and Significance of Genetic Variation in Endocrine Systems

“…Each of these could correspond to a subclass of hypertensive disease in man. Variation in other responses to stress, such as gastric ulceration (Sines, 1959; Wilson, 1967), and resistance to radiation (Pachciarz & Teague, 1975), has also been found in laboratory animals. Variation in the nervous input to the endocrine system must also be an important site of variation, and a route through which the social environment and social change can act.…”

“…Since both I I-and 18-hydroxylations occur in mitochondria, and no differences were found in the Michaelis constants of the enzymes, they suggested that the locus codes for a protein in the mitochondria which determines the spatial distribution of the two hydroxylases. This would be an 'architectural ' gene according to Paigen's (1971) classification. In mice the proportions of corticosterone and a substance identified as I I-deoxycortisol synthesized by the adrenal were shown to be controlled by variation at a single locus (Badr & Spickett, 1965).…”