Different Risk Factors for Graft Survival Between Living-Related and Deceased Donor Kidney Transplantation

Zhang, H.; Wei, Yantao; Liu, L.; Li, J.; Deng, Ronghai; Xiong, Ye; Yuan, Xiaopeng; He, Xiaoshun; Fu, Qian; Wang, C.

doi:10.1016/j.transproceed.2018.03.047

Cited by 12 publications

(13 citation statements)

References 19 publications

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“…33 Risk factors for graft survival in LRKT were pretransplant dialysis duration (HR = 1.023 per month; P = .046), DGF (HR = 5.785; P = .02), and acute rejection (HR = 2.706; P = .04), whereas risk factors for graft survival in DDKT were recipient age (HR = 1.066 per year; P = .004), recipient history of diabetes (HR = 3.011; P = .03), pretransplant positive PRAs (HR = 3.353; P = .02), and donor HTN (HR = 2.660; P = .046). 34 Of note in this cohort, patients who received LRKT were younger (33 vs 44 years old), healthier (less diabetes, shorter duration of dialysis), and received organs with closer HLA matches than DDKT recipients. 33,34 Donor Management.…”

Section: Discussionmentioning

confidence: 84%

“…34 Of note in this cohort, patients who received LRKT were younger (33 vs 44 years old), healthier (less diabetes, shorter duration of dialysis), and received organs with closer HLA matches than DDKT recipients. 33,34 Donor Management. As the waitlist for kidney transplants grows, interest in expanding the pool of available organs increases.…”

Section: Discussionmentioning

confidence: 84%

“…Dr Wang's group from China published 2 large, retrospective, single-center studies based on approximately 1100 patients who underwent either LRKT or DDKT from 2004 to 2015. 33,34 The group found better 1-, 3-, and 5-year graft survival after LRKT (98.8%, 98.5%, and 97.2%, respectively) compared with DDKT (94.9%, 91.3%, and 91.3%). 33 DDKT had a higher rate of DGF (20.6% vs 2.6%, P < .001).…”

Section: Discussionmentioning

confidence: 93%

See 2 more Smart Citations

Abdominal Organ Transplantation: Noteworthy Literature in 2018

Zerillo

Schlichting

Sakai

2019

Semin Cardiothorac Vasc Anesth

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A PubMed search revealed 1382 articles on pancreatic transplantation, 781 on intestinal transplantation, more than 7200 on kidney transplantation, and more than 5500 on liver transplantation published between January 1, 2018, and December 31, 2018. After narrowing the list down to human studies, 436 pancreatic, 302 intestinal, 1920 liver, and more than 2000 kidney transplantation studies were screened for inclusion in this review.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

Abdominal Organ Transplantation: Noteworthy Literature in 2018

Zerillo

Schlichting

Sakai

2019

Semin Cardiothorac Vasc Anesth

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“…The study population consisted of 330 adult patients (i.e., age ≥ 19 years) who underwent elective LDKT at Seoul St. Mary’s Hospital between January 2016 and December 2017. Pediatric patients (i.e., age < 19 years), those undergoing deceased-donor or ABO-incompatible KT, patients undergoing multiorgan transplantation including the kidney, and those undergoing re-transplantation were excluded from the study because these patients require various and complex immunosuppression regimens or surgical technique application [13,14,15,16,17]. Patients with defective or missing recipient and donor graft data were also excluded.…”

Section: Methodsmentioning

confidence: 99%

Exposure to Hyperchloremia Is Associated with Poor Early Recovery of Kidney Graft Function after Living-Donor Kidney Transplantation: A Propensity Score-Matching Analysis

Park

Yun

et al. 2019

JCM

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The effects of hyperchloremia on kidney grafts have not been investigated in patients undergoing living-donor kidney transplantation (LDKT). In this study, data from 200 adult patients undergoing elective LDKT between January 2016 and December 2017 were analyzed after propensity score (PS) matching. The patients were allocated to hyperchloremia and non-hyperchloremia groups according to the occurrence of hyperchloremia (i.e., ≥110 mEq/L) immediately after surgery. Poor early graft recovery was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 during the first 48 hours after surgery. After PS matching, no significant differences in perioperative recipient or donor graft parameters were observed between groups. Although the total amount of crystalloid fluid infused during surgery did not differ between groups, the proportions of main crystalloid fluid type used (i.e., 0.9% normal saline vs. Plasma Solution-A) did. The eGFR increased gradually during postoperative day (POD) 2 in both groups. However, the proportion of patients with eGFR > 60 mL/min/1.73 m2 on POD 2 was higher in the non-hyperchloremia group than in the hyperchloremia group. In this PS-adjusted analysis, hyperchloremia was significantly associated with poor graft recovery on POD 2. In conclusion, exposure to hyperchloremia may have a negative impact on early graft recovery in LDKT.

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“…immunological and hormonal changes compared to living donors (25,26), other studies have reported desirable results from the function of the DD renal transplantation (27,28). Even though various studies have been carried out in order to determine the effect of cadaveric donors on renal transplantation rejection, these estimations vary from one study to another, and some cases have rejected the results of other studies.…”

mentioning

confidence: 99%

Short term and long term survival rate and risk factors of graft rejection after deceased donor kidney transplantation: a systematic review and meta-analysis

Aghamir¹,

Saatchi²

2020

Preprint

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The purpose of the current meta-analysis is to determine the short-term and long-term graft and patient survival after deceased donor (DD) transplantation, as well as to determine prognostic factors. Method : Articles published until March 2019 in PubMed, Scopus, and Google Scholar databases, reporting short-term and/or long term graft and patient survival were searched. In addition to this, we included articles that analyzed the hazard ratio (HR) of graft rejection and/or patient death caused by DD related risk factors. The summary measures of this study included the survival rate, the HR of graft rejection, and patient death in response to DD related risk factors. This study, which is the first comprehensive meta-analysis of graft and patient survival rates after transplantation from the deceased donor, showed that overall short and long-term survival of graft and patient is desirable. In addition to this, it confirms that ECD and DCD recipients have a lower graft survival rate than standard donors.

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Different Risk Factors for Graft Survival Between Living-Related and Deceased Donor Kidney Transplantation

Cited by 12 publications

References 19 publications

Abdominal Organ Transplantation: Noteworthy Literature in 2018

Abdominal Organ Transplantation: Noteworthy Literature in 2018

Exposure to Hyperchloremia Is Associated with Poor Early Recovery of Kidney Graft Function after Living-Donor Kidney Transplantation: A Propensity Score-Matching Analysis

Short term and long term survival rate and risk factors of graft rejection after deceased donor kidney transplantation: a systematic review and meta-analysis

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